Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

1997 • 1,435 citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

1999 • 1,344 citations

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

1997 • 878 citations

KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness

1999 • 853 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Mutations in the hminK gene cause long QT syndrome and suppress lKs function

1997 • 763 citations

Influence of the Genotype on the Clinical Course of the Long-QT Syndrome

1998 • 739 citations

ECG T-Wave Patterns in Genetically Distinct Forms of the Hereditary Long QT Syndrome

1995 • 618 citations

Measurement of heart rate and Q-T interval in the conscious mouse

1998 • 525 citations

Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment

1998 • 415 citations

Inner Ear Defects Induced by Null Mutationof the isk Gene

1996 • 395 citations

Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf

1999 • 386 citations

Regulation of a Heart Potassium Channel by Protein Kinase A and C

1988 • 317 citations

Four Kinetically Distinct Depolarization-activated K+ Currents in Adult Mouse Ventricular Myocytes

1999 • 309 citations

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

2000 • 297 citations

[RARE CARDIAC ARRYTHMIAS OF THE PEDIATRIC AGE. II. SYNCOPAL ATTACKS DUE TO PAROXYSMAL VENTRICULAR FIBRILLATION. (PRESENTATION OF 1ST CASE IN ITALIAN PEDIATRIC LITERATURE)].

1963 • 241 citations

Replacement by Homologous Recombination of the minK Gene With lacZ Reveals Restriction of minK Expression to the Mouse Cardiac Conduction System

1999 • 188 citations

In vitro validation of a new cardiac catheter technique for recording monophasic action potentials

1986 • 178 citations

Immunohistochemical Localization of the Na-K-Cl Co-transporter (NKCC1) in the Gerbil Inner Ear

1997 • 177 citations

Mutation of the Na-K-Cl Co-Transporter Gene Slc12a2 Results in Deafness in Mice

1999 • 163 citations

A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K⁺ Currents

1998 • 150 citations

Inherited Long QT Syndromes:

1999 • 140 citations

Involvement of IsK-Associated K ⁺ Channel in Heart Rate Control of Repolarization in a Murine Engineered Model of Jervell and Lange-Nielsen Syndrome

1998 • 135 citations

Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse

2000 • 128 citations

The Behavioral Syndrome Caused by 3,3′-Iminodipropionitrile and Related Nitriles in the Rat Is Associated with Degeneration of the Vestibular Sensory Hair Cells

1993 • 117 citations

Inherited diseases of the inner ear in man in the light of studies on the mouse.

1968 • 115 citations

Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation

1991 • 111 citations

Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5

1998 • 109 citations

Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin

2000 • 106 citations

Imprinting of mouse Kvlqt1 is developmentally regulated

1998 • 98 citations

Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N) Mutation Linked to Familial Hypertrophic Cardiomyopathy

2001 • 91 citations

Slowly activating voltage-dependent K+ conductance is apical pathway for K+ secretion in vestibular dark cells

1994 • 90 citations

Genetics, molecular mechanisms and management of long QT syndrome

1998 • 65 citations

Autosomal recessive long-QT syndrome (Jervell Lange-Nielsen syndrome) is genetically heterogeneous

1997 • 62 citations

Endothelin-1 Inhibits the Slow Component of Cardiac Delayed Rectifier K ⁺ Currents via a Pertussis Toxin–Sensitive Mechanism

1997 • 37 citations

The Development of the Inner Ear in Mice Homozygous for Shaker-with-Syndactylism

1963 • 21 citations

Dispersion of Ventricular Repolarization in the Voltage Domain

1998 • 15 citations