Use of population isolates for mapping complex traits

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees

1998 • 3,077 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1999 • 1,453 citations

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

1997 • 1,435 citations

fw2.2 : A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size

2000 • 1,357 citations

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

1996 • 1,201 citations

Variations on a Theme: Cataloging Human DNA Sequence Variation

1997 • 1,064 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

1996 • 834 citations

A genome-wide search for asthma susceptibility loci in ethnically diverse populations

1997 • 712 citations

A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium Test

1998 • 674 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

2000 • 528 citations

Extensions to multivariate normal models for pedigree analysis

1982 • 517 citations

A Haplotype-Based Haplotype Relative Risk’ Approach to Detecting Allelic Associations

1992 • 502 citations

Molecular genetics of the Finnishdisease heritage

1999 • 492 citations

DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

1998 • 485 citations

An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians

1998 • 484 citations

A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity

1995 • 465 citations

A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci.

1995 • 460 citations

Effects of Misspecifying Genetic Parameters in Lod Score Analysis

1986 • 454 citations

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2

1999 • 399 citations

Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma

1998 • 396 citations

An international two–stage genome–wide search for schizophrenia susceptibility genes

1995 • 385 citations

The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

1998 • 373 citations

Predisposing Gene for Early-Onset Prostate Cancer, Localized on Chromosome 1q42.2-43

1998 • 365 citations

Population choice in mapping genes for complex diseases

1999 • 356 citations

A Second-Generation Genomewide Screen for Asthma-Susceptibility Alleles in a Founder Population

2000 • 335 citations

Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis

1994 • 325 citations

Multipoint analysis of human quantitative genetic variation.

1990 • 311 citations

A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians.

1999 • 309 citations

Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

1997 • 308 citations

A Genomewide Screen for Schizophrenia Genes in an Isolated Finnish Subpopulation, Suggesting Multiple Susceptibility Loci

1999 • 286 citations

A non–syndromic form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q

1994 • 281 citations

Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23

1998 • 271 citations

Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28

2000 • 259 citations

Linkage disequilibrium mapping in isolated populations: The example of Finland revisited

1998 • 247 citations

Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22

1994 • 243 citations

The Finland–United States Investigation of Non–Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome Scan for Genes That Predispose to Type 2 Diabetes

2000 • 233 citations

Assessment of Linkage Disequilibrium by the Decay of Haplotype Sharing, with Application to Fine-Scale Genetic Mapping

1999 • 233 citations

Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.

1996 • 230 citations

Estimating Scandinavian and Gaelic Ancestry in the Male Settlers of Iceland

2000 • 222 citations

Multipoint oligogenic linkage analysis of quantitative traits

1997 • 218 citations

Genetic Association Mapping Based on Discordant Sib Pairs: The Discordant-Alleles Test

1998 • 214 citations

Dual Origins of Finns Revealed by Y Chromosome Haplotype Variation

1998 • 209 citations

A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2

1996 • 209 citations

Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations.

1993 • 196 citations

The DNA revolution in population genetics

1998 • 195 citations

The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes

2000 • 195 citations

The Power to Detect Linkage in Complex Disease by Means of Simple LOD-Score Analyses

1998 • 191 citations

Genome Scan of Schizophrenia

1998 • 190 citations

Linkage Analysis in the Presence of Errors IV: Joint Pseudomarker Analysis of Linkage and/or Linkage Disequilibrium on a Mixture of Pedigrees and Singletons When the Mode of Inheritance Cannot Be Accurately Specified

2000 • 187 citations

The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen

1998 • 173 citations

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

Combined Analysis of Hereditary Prostate Cancer Linkage to 1q24-25: Results from 772 Hereditary Prostate Cancer Families from the International Consortium for Prostate Cancer Genetics

2000 • 166 citations

Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations

2000 • 165 citations

Mapping a disease locus by allelic association

1998 • 163 citations

Fine-Scale Genetic Mapping Based on Linkage Disequilibrium: Theory and Applications

1997 • 159 citations

Genomewide Scan for Familial Combined Hyperlipidemia Genes in Finnish Families, Suggesting Multiple Susceptibility Loci Influencing Triglyceride, Cholesterol, and Apolipoprotein B Levels

1999 • 156 citations

Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion

1998 • 145 citations

Likelihood methods for locating disease genes in nonequilibrium populations.

1995 • 144 citations

A Conditional Inference Framework for Extending the Transmission/Disequilibrium Test

1998 • 144 citations

Sibling-Based Tests of Linkage and Association for Quantitative Traits

1999 • 132 citations

Direct Power Comparisons between Simple LOD Scores and NPL Scores for Linkage Analysis in Complex Diseases

1999 • 132 citations

Use of isolated inbred human populations for identification of disease genes

1998 • 132 citations

The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases. II. Individual Genotyping

1999 • 127 citations

Positional Cloning of Disease Genes: Advantages of Genetic Isolates

1999 • 120 citations

Littlewood's miscellany

1988 • 118 citations

Use of Parents, Sibs, and Unrelated Controls for Detection of Associations between Genetic Markers and Disease

1998 • 115 citations

Random search for shared chromosomal regions in four affected individuals: the assignment of a new hereditary ataxia locus.

1995 • 108 citations

Mapping a gene for combined hyperlipidaemia in a mutant mouse strain

1998 • 102 citations

Likelihood Analysis of Disequilibrium Mapping, and Related Problems

1998 • 95 citations

Disequilibrium Mapping: Composite Likelihood for Pairwise Disequilibrium

1996 • 91 citations

Support for linkage of familial combined hyperlipidemia to chromosome 1q21–q23 in Chinese and German families

2000 • 79 citations

Gene Mapping in Isolated Populations: New Roles for Old Friends?

1999 • 78 citations

Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo

2000 • 77 citations

Gamete-Competition Models

2000 • 67 citations

Littlewood's Miscellany.

1989 • 15 citations

Deleted Work

1955 • 0 citations