Further insight into the mode of action of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

1984 • 313 citations

Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum

1974 • 289 citations

Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP

1984 • 199 citations

V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 148 citations

Synthesis and chemistry of 5,6-dihydropyridinium salt adducts. Synthons for general electrophilic and nucleophilic substitution of the piperidine ring system

1980 • 139 citations

I. MPTP neurotoxicity: An overview and characterization of phases of toxicity

1985 • 119 citations

VII. Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 38 citations

Inhibition of dopamine uptake by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a cause of parkinsonism

1984 • 38 citations

Conversion of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (mptp) and its 5‐methyl analog into pyridinium salts

1984 • 35 citations

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations

1984 • 33 citations

α-Cyanation of Tertiary Amines

1980 • 30 citations

Chronic Parkinsonism Secondary to Intranasal Administration of a Product of Meperidine-Analogue Synthesis

1984 • 23 citations

Effects of N-substituted phenyltetrahydropyridines on cerebral high-affinity synaptosomal uptake of dopamine and other monoamines in several mammalian species

1984 • 19 citations