Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+)

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects

1985 • 210 citations

V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 148 citations

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate

1985 • 129 citations

Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment

1986 • 125 citations

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1985 • 118 citations

VI. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: Relationships between monoamine oxidase, MPTP metabolism and neurotoxicity

1985 • 97 citations

The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals

1985 • 96 citations

Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B

1985 • 74 citations

Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments

1985 • 70 citations

A catalyst function for MPTP in superoxide formation

1985 • 49 citations

Brain Enzyme Is the Target of Drug Toxin

1984 • 36 citations

Interactions of the 1-methyl-4-phenyl-2, 3-dihydropyridinium species with synthetic dopamine-melanin

1986 • 31 citations

Metal ion-induced activation of molecular oxygen in pigmented polymers

1986 • 17 citations