Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1983 • 921 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Establishment and identification of small cell lung cancer cell lines having classic and variant features

1986 • 896 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Oncogenes in solid human tumours

1982 • 467 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.

1985 • 174 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei

1985 • 127 citations

Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells.

1986 • 95 citations

Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium

1982 • 90 citations

Resistance to adriamycin: relationship of cytotoxicity to drug uptake and DNA single- and double-strand breakage in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1986 • 77 citations

Purification and characterization of Plasmodium berghei DNA topoisomerases I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage

1986 • 77 citations

The formation and resealing of intercalator-induced DNA strand breaks in isolated L1210 cell nuclei

1982 • 73 citations

Heterogeneity of the kinetoplast DNA molecules of Trypanosoma cruzi

1977 • 72 citations

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

1988 • 72 citations

Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro.

1986 • 62 citations

Molecular cloning of a DNA fragment from human chromosome 14(14q11) involved in T-cell malignancies.

1985 • 48 citations

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene

1986 • 43 citations

The production of topoisomerase II-mediated DNA cleavage in human leukemia cells predicts their susceptibility to 4′-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA)

1986 • 39 citations

Elliptinium, a DNA intercalating agent with broad antitumor activity in a human tumor cloning system

1987 • 34 citations

A type-II DNA topoisomerase and a catenating protein from the transplantable VX2 carcinoma

1985 • 34 citations

Inhibition of the reactions catalysed by a type I topoisomerase and catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of the catenating reaction.

1984 • 22 citations

Interrelations between anti-tumour activity, DNA breakage, and DNA binding kinetics for 9-aminoacridinecarboxamide anti-tumour agents.

1986 • 21 citations

Characterization of the topoisomerase II-induced cleavage sites in the c-myc proto-oncogene

1986 • 16 citations

The in vitro involvement of topoisomerase II in the activity of aza-ellipticine analogues is not correlated with drug activity on isolated nuclei

1986 • 16 citations

Interaction between ellipticine derivatives and circular supercoiled DNA as revealed by gel electrophoresis. Possible relationship with the mechanisms of cytotoxicity

1986 • 14 citations

In vivo and in vitro stimulation by antitumor drugs of the topoisomerase II-induced cleavage sites in c-myc proto-oncogene.

1987 • 4 citations

Effects of the 6-alkyl substitution of ellipticine on the uptake by NIH-3T3 cells and on the cytotoxicity.

1988 • 2 citations

Deleted Work

1955 • 0 citations