Two SNPs in the promoter region of the CTLA‐4 gene affect binding of transcription factors and are associated with human myasthenia gravis

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Gametic Disequilibrium Measures: Proceed With Caution

1987 • 930 citations

Alternative splicing: multiple control mechanisms and involvement in human disease

2002 • 643 citations

A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION

2005 • 497 citations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 • 418 citations

Costimulatory blockade in patients with rheumatoid arthritis: A pilot, dose‐finding, double‐blind, placebo‐controlled clinical trial evaluating CTLA‐4Ig and LEA29Y eighty‐five days after the first infusion

2002 • 384 citations

CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms

2001 • 359 citations

A Common Autoimmunity Predisposing Signal Peptide Variant of the Cytotoxic T-lymphocyte Antigen 4 Results in Inefficient Glycosylation of the Susceptibility Allele

2002 • 278 citations

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

1999 • 257 citations

A Native Soluble Form of CTLA-4

2000 • 238 citations

Regulation of CTLA-4 expression during T cell activation.

1996 • 233 citations

Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease

2000 • 227 citations

Finding signals that regulate alternative splicing in the post-genomic era.

2002 • 214 citations

A CTLA-4 gene polymorphism at position −318 in the promoter region affects the expression of protein

2002 • 198 citations

Alterations of pre‐mRNA splicing in cancer

2005 • 196 citations

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

2002 • 143 citations

CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region

2002 • 143 citations

CCAAT/enhancer binding proteins in normal mammary development and breast cancer

2002 • 104 citations

Increased Expression of Soluble Cytotoxic T‐Lymphocyte‐Associated Antigen‐4 Molecule in Patients with Systemic Lupus Erythematosus

2003 • 102 citations

Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte–associated antigen 4, and programmed cell death 1 in primary Sjögren's syndrome

2003 • 90 citations

Regulation of Surface and Intracellular Expression of CTLA‐4 on Human Peripheral T Cells

2001 • 87 citations

Genetic association of Ctla-4 to myasthenia gravis with thymoma

1998 • 86 citations

Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor

2000 • 77 citations

Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis

2001 • 75 citations

Anti-CTLA-4 Antibody Treatment Triggers Determinant Spreading and Enhances Murine Myasthenia Gravis

2001 • 72 citations

Chromosomal Localization of the Four Genes (NFIA, B, C, and X) for the Human Transcription Factor Nuclear Factor I by FISH

1995 • 69 citations

Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection

1999 • 59 citations

Alternative Splicing Regulation Impacts Heart Development

2005 • 58 citations

Suppression of experimental myasthenia gravis, a B cell‐mediated autoimmune disease, by blockade of IL‐18

2001 • 57 citations

Complex organization of CTF/NF-I, C/EBP, and HNF3 binding sites within the promoter of the liver-specific vitellogenin gene

1994 • 55 citations

Purified cofactors and histone H1 mediate transcriptional regulation by CTF/NF-I.

1992 • 45 citations

A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4⁺T cells

2003 • 42 citations

CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis

2002 • 38 citations

Regulation of alternative pre-mRNA splicing

2002 • 33 citations

IFN-β1a Modulates the Expression of CTLA-4 and CD28 Splice Variants in Human Mononuclear Cells: Induction of Soluble Isoforms

2001 • 23 citations

CTLA-4 (CD152) expression in peripheral blood T cells in Kawasaki disease

2003 • 12 citations