Molecular Biology of Acute Lymphoblastic Leukemia

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

2003 • 2,949 citations

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

2004 • 2,631 citations

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

2002 • 1,959 citations

Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).

1995 • 1,374 citations

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

2009 • 1,360 citations

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

2002 • 1,112 citations

Epidemiology of childhood cancer

2010 • 934 citations

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

2009 • 915 citations

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

2011 • 814 citations

Origins of chromosome translocations in childhood leukaemia

2003 • 683 citations

Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

2009 • 680 citations

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

2007 • 649 citations

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

2000 • 641 citations

Infection, immune responses and the aetiology of childhood leukaemia

2006 • 613 citations

A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial

2007 • 608 citations

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

2003 • 598 citations

Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation

2004 • 557 citations

JAK mutations in high-risk childhood acute lymphoblastic leukemia

2009 • 553 citations

Proposals for immunological classification of acute leukemias.

1995 • 543 citations

In utero rearrangements in the trithorax-related oncogene in infant leukaemias

1993 • 450 citations

Lancet Oncol 10

2013 • 433 citations

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

2008 • 432 citations

Molecular pathogenesis of T-cell leukaemia and lymphoma

2008 • 410 citations

New insights to the MLL recombinome of acute leukemias

2009 • 405 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region

2002 • 388 citations

Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia

2008 • 358 citations

Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia

1999 • 356 citations

IKZF1(Ikaros) Deletions inBCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

2009 • 301 citations

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia

2007 • 278 citations

Molecular genetics, natural history and the demise of childhood leukaemia

1999 • 266 citations

New therapeutic strategies for the treatment of acute lymphoblastic leukaemia

2007 • 231 citations

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non–high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol

2010 • 223 citations

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

2008 • 223 citations

Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia

2004 • 218 citations

Genome-wide Interrogation of Germline Genetic Variation Associated With Treatment Response in Childhood Acute Lymphoblastic Leukemia

2009 • 217 citations

Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects

1991 • 214 citations

The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling

2007 • 191 citations

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

2009 • 191 citations

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

2008 • 179 citations

Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B–ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease

2002 • 176 citations

High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative

2005 • 173 citations

Regulating antigen-receptor gene assembly

2003 • 157 citations

Gene expression profiling–based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

2009 • 156 citations

Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia

2004 • 153 citations

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions

2009 • 150 citations

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

2009 • 150 citations

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

2010 • 139 citations

Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage

1999 • 136 citations

Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia

1993 • 136 citations

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes

2005 • 129 citations

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

2010 • 129 citations

Lack of CpG Island Methylator Phenotype Defines a Clinical Subtype of T-Cell Acute Lymphoblastic Leukemia Associated With Good Prognosis

2005 • 128 citations

Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood

2009 • 127 citations

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

2010 • 125 citations

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia

2007 • 125 citations

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting

2010 • 120 citations

Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement

2007 • 116 citations

Origins of “late” relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes

2001 • 113 citations

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

2009 • 112 citations

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale

2010 • 106 citations

MRD Detection in Acute Lymphoblastic Leukemia Patients Using Ig/TCR Gene Rearrangements as Targets for Real-Time Quantitative PCR

2009 • 104 citations

It's T-ALL about Notch

2008 • 100 citations

Recent Research Advances in Childhood Acute Lymphoblastic Leukemia

2010 • 100 citations

Genetic aberrations in paediatric acute leukaemias and implications for management of patients

2010 • 98 citations

Precursor-B-ALL with DH–JH gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14

2001 • 97 citations

Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone

2003 • 94 citations

ABL1 fusion genes in hematological malignancies: a review

2011 • 94 citations

Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease

1998 • 93 citations

Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome‐positive adult acute lymphoblastic leukemia

2007 • 83 citations

The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures

2010 • 82 citations

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes

2006 • 81 citations

Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurrence of second T-ALL

2003 • 78 citations

Global Genomic Characterization of Acute Lymphoblastic Leukemia

2008 • 74 citations

Development of human T lymphocytes and their thymus-dependency.

1990 • 70 citations

11q23/MLL Acute Leukemia : Update of Clinical Aspects

2010 • 68 citations

Improving outcomes for high‐risk ALL: Translating new discoveries into clinical care

2011 • 67 citations

TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse

2004 • 67 citations

Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

2007 • 65 citations

Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: implications for detection of minimal residual disease

2003 • 63 citations

DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4

2009 • 58 citations

Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia

1999 • 57 citations

T‐cell acute lymphoblastic leukaemia: recent molecular biology findings

2011 • 57 citations

The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party

2010 • 57 citations

Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population

2011 • 55 citations

Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias

1999 • 42 citations

Genomic analysis of acute leukemia

2009 • 31 citations

Prognostic factors in childhood acute lymphoblastic leukemia

2003 • 16 citations

Pattern of immunoglobulin and T-cell receptor (Ig/TCR) gene rearrangements in Polish pediatric acute lymphoblastic leukemia patients—implications for RQ-PCR-based assessment of minimal residual disease

2006 • 15 citations

Implementation of the standard strategy for identification of Ig/TCR targets for minimal residual disease diagnostics in B-cell precursor ALL pediatric patients: Polish experience

2008 • 14 citations

Genetic variation and the risk of acute lymphoblastic leukemia

2010 • 13 citations

Low-penetrance susceptibility to hematological malignancy

2010 • 7 citations

MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1)

2010 • 2 citations

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