Precursor-B-ALL with DH–JH gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

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The human immunoglobulin VH repertoire

1995 • 469 citations

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

1998 • 401 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia

1999 • 356 citations

Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes

1998 • 339 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1997 • 300 citations

Molecular genetics, natural history and the demise of childhood leukaemia

1999 • 266 citations

Fates of human B-cell precursors

2000 • 256 citations

Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders

1991 • 218 citations

Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations

1997 • 217 citations

Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects

1991 • 214 citations

Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia

2000 • 203 citations

Ordering of Human Bone Marrow B Lymphocyte Precursors by Single-Cell Polymerase Chain Reaction Analyses of the Rearrangement Status of the Immunoglobulin H and L Chain Gene Loci

1996 • 186 citations

Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease

1999 • 174 citations

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia.

1988 • 160 citations

Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia.

1996 • 156 citations

Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin.

1991 • 140 citations

Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage

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VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia [see comments]

1992 • 123 citations

A polymerase chain reaction study of the stability of Ig heavy-chain and T-cell receptor delta gene rearrangements between presentation and relapse of childhood B-lineage acute lymphoblastic leukemia

1994 • 119 citations

Molecular genetics, natural history and the demise of childhood leukaemia

1999 • 110 citations

Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR

2000 • 110 citations

IgM Heavy Chain Complementarity-Determining Region 3 Diversity Is Constrained by Genetic and Somatic Mechanisms Until Two Months After Birth

1999 • 109 citations

Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: recommendations for optimal results.

1993 • 106 citations

Developmental Regulation of the Human Antibody Repertoire^a

1995 • 106 citations

Distinct ongoing Ig heavy chain rearrangement processes in childhood B- precursor acute lymphoblastic leukemia

1993 • 104 citations

Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease

1998 • 93 citations

Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event.

1992 • 85 citations

Flow cytometric detection of intracellular antigens for immunophenotyping of normal and malignant leukocytes.

1996 • 82 citations

Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia

1993 • 78 citations

Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis.

1994 • 75 citations

The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype

2000 • 66 citations

Immunophenotyping of leukaemias and non-Hodgkin's lymphomas. Immunological markers and their CD codes.

1988 • 60 citations

Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences

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B precursor acute lymphoblastic leukemia third complementarity‐determining regions predominantly represent an unbiased recombination repertoire: Leukemic transformation frequently occurs in fetal life

1994 • 57 citations

Early Onset of Immunoglobulin Heavy Chain Gene Rearrangements in Normal Human Bone Marrow CD34+ Cells

1997 • 57 citations

Clonal rearrangements in childhood and adult precursor B acute lymphoblastic leukemia: a comparative polymerase chain reaction study using multiple sets of primers

1999 • 57 citations

Immunoglobulin heavy chain gene fingerprinting reveals widespread oligoclonality in B-lineage acute lymphoblastic leukaemia.

1991 • 52 citations

Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study

2000 • 50 citations

Ig DH Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B–Cell Marker CD19 in Normal Human Bone Marrow

1997 • 48 citations

Analysis of clonal rearrangements of the Ig heavy chain locus in acute leukemia

1996 • 45 citations

Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias

1999 • 42 citations

Third complementarity determining region (CDR III) sequence analysis in childhood B-lineage acute lymphoblastic leukaemia: implications for the design of oligonucleotide probes for use in monitoring minimal residual disease.

1992 • 40 citations

Molecular discrimination between relapsed and secondary acute lymphoblastic leukemia: Proposal for an easy strategy

2001 • 39 citations

The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B precursor cell stage.

1992 • 35 citations

Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia

1996 • 26 citations

Immunoglobulin lambda isotype gene rearrangements in B cell malignancies

2001 • 26 citations