Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway.

Methods of Hormone Radioimmunoassay

1978 • 2,097 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

1980 • 535 citations

Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranes

1971 • 521 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface

1979 • 237 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

1978 • 148 citations

Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic Analysis

1978 • 135 citations

Transglutaminase activity in normal and transformed cells.

1977 • 121 citations

Water-Soluble Insulin Receptors from Human Lymphocytes

1972 • 108 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.

1979 • 93 citations

Insulin-dependent regulation of the insulin-sensitivity of adipocytes

1978 • 86 citations

Ultrastructural antibody localization of alpha2-macroglobulin in membrane-limited vesicles in cultured cells.

1978 • 73 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations