Vimentin serves as a phosphate sink during the apparent activation of protein kinases by okadaic acid in mammalian cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates

1979 • 642 citations

Site-specific phosphorylation induces disassembly of vimentin filaments in vitro

1987 • 442 citations

Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment.

1985 • 428 citations

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

1990 • 328 citations

Signal integration at the level of protein kinases, protein phosphatases and their substrates

1992 • 314 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

Cellular and Molecular Biology of Intermediate Filaments

1990 • 262 citations

HeLa cells contain intermediate-sized filaments of the prekeratin type

1979 • 240 citations

Two distinct attachment sites for vimentin along the plasma membrane and the nuclear envelope in avian erythrocytes: a basis for a vectorial assembly of intermediate filaments.

1987 • 227 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Functions of intermediate filaments

1989 • 178 citations

Cytoskeletal integrity in interphase cells requires protein phosphatase activity.

1992 • 174 citations

Phosphorylation and disassembly of intermediate filaments in mitotic cells.

1989 • 167 citations

The 9L rat brain tumor: Description and application of an animal model

1981 • 166 citations

Intermediate Filaments: Possible Functions as Cytoskeletal Connecting Links Between the Nucleus and the Cell Surface^a

1985 • 160 citations

Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure

1989 • 158 citations

Recent insights into the assembly, dynamics, and function of intermediate filament networks

1991 • 157 citations

Molecular and Cellular Effects of Heat-shock and Related Treatments of Mammalian Tissue-culture Cells

1982 • 154 citations

The cytoskeleton : an introductory survey

1986 • 151 citations

Intermediate Filaments

1985 • 147 citations

Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish.

1989 • 141 citations

Phosphorylation of keratin and vimentin polypeptides in normal and transformed mitotic human epithelial amnion cells: behavior of keratin and vimentin filaments during mitosis.

1983 • 141 citations

Proteolysis of Vimentin and Desmin by the Ca²⁺-Activated Proteinase Specific for These Intermediate Filament Proteins

1983 • 139 citations

Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase.

1989 • 134 citations

Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinases

1981 • 128 citations

Intermediate Filament Networks: Organization And Possible Functions Of A Diverse Group Of Cytoskeletal Elements

1986 • 120 citations

Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils.

1991 • 118 citations

Proteolysis of vimentin and desmin by the Ca2+-activated proteinase specific for these intermediate filament proteins.

1983 • 104 citations

The cytoskeleton. An introductory survey

1986 • 104 citations

The regulation of intermediate filament reorganization in mitosis.

1991 • 103 citations

Phosphorylation in vitro of vimentin by protein kinases A and C is restricted to the head domain

1989 • 99 citations

Looking for a function

1987 • 87 citations

Apparent “activation” of protein kinases by okadaic acid class tumor promoters

1989 • 87 citations

Phosphorylation of the 10-nm filament protein from Chinese hamster ovary cells.

1979 • 83 citations

Follicle-stimulating hormone-dependent phosphorylation of vimentin in cultures of rat Sertoli cells.

1983 • 75 citations

Intermediate filaments: known structure, unknown function

1989 • 69 citations

The Mammalian Stress Response and the Cytoskeleton: Alterations in Intermediate Filaments^a

1985 • 67 citations

Transient change of organization of vimentin filaments during mitosis as demonstrated by a monoclonal antibody

1984 • 66 citations

Evidence that Ser-82 is a unique phosphorylation site on vimentin for CA2+-calmodulin-dependent protein kinase II

1991 • 64 citations

Specific binding ofadaic acid, a new tumor promoter in mouse skin

1989 • 63 citations

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

1991 • 61 citations

Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

1988 • 60 citations

Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells

1992 • 59 citations

Vimentin, a cytoskeletal substrate of protein kinase C

1988 • 48 citations

Induction of heat‐shock response and alterations of protein phosphorylation by a novel topoisomerase ii inhibitor, withangulatin A, in 9L rat brain tumor cells

1991 • 34 citations

Intermediate Filament-Associated Proteins

1990 • 30 citations

Regulation of protein phosphorylation of the intermediate-sized filament vimentin in the ciliary epithelium of the mammalian eye.

1985 • 29 citations

Angiotensin II stimulates vimentin phosphorylation via a Ca2+-dependent, protein kinase C-independent mechanism in cultured vascular smooth muscle cells.

1988 • 26 citations

Okadaic acid as an inducer of the 78‐kDa glucose‐regulated protein in 9L rat brain tumor cells

1993 • 14 citations