Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease.

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

1976 • 3,140 citations

Development of a Crohn's Disease Activity Index

1976 • 3,024 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Nitric oxide synthase activity in ulcerative colitis and Crohn's disease

1993 • 468 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

1990 • 399 citations

Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.

1995 • 363 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Increased nitric oxide synthesis in ulcerative colitis

1993 • 347 citations

Nitric oxide synthase induction and intestinal epithelial cell viability in rats

1993 • 196 citations

Comparison of delayed release 5 aminosalicylic acid (mesalazine) and sulphasalazine in the treatment of mild to moderate ulcerative colitis relapse.

1988 • 193 citations

Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration.

1980 • 186 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats

1993 • 181 citations

Early mucosal changes in Crohn's disease.

1993 • 136 citations

Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis.

1994 • 130 citations

Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro.

1993 • 100 citations

Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro

1993 • 95 citations

Increased respiratory burst of leukocytes in inflammatory bowel diseases--the analysis of free radical generation by using chemiluminescence probe.

1987 • 89 citations

Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst.

1993 • 76 citations

Nitrite from inflammatory cells—A cancer risk factor in ulcerative colitis?

1990 • 61 citations

Enzyme linked immunosorbent assay (ELISA) and immunoprecipitation studies on anti-goblet cell antibody using a mucin producing cell line in patients with inflammatory bowel disease.

1994 • 60 citations

Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease.

1992 • 50 citations

Crohn's disease monocytes are primed for accentuated release of toxic oxygen metabolites

1993 • 45 citations

NO x generation by cultured small intestinal epithelial cells

1995 • 44 citations

A simple index for assessment of disease activity in patients with ulcerative colitis.

1990 • 23 citations