Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Detection, delineation, measurement and display of cavities in macromolecular structures

1994 • 964 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 • 738 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

Humanized xenobiotic response in mice expressing nuclear receptor SXR

2000 • 655 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Cytochrome P450 3A

1999 • 557 citations

Superconducting Single Crystals of Tl2Ba2CaCu2O8 and YBa2Cu4O8: Crystal Structures in the Vicinity of Tc

1998 • 543 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6

1997 • 486 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ

1998 • 256 citations

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

1996 • 231 citations

Ligand-induced stabilization of PPARγ monitored by NMR spectroscopy: implications for nuclear receptor activation

2000 • 168 citations

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

1997 • 135 citations

Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

1997 • 121 citations

X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation

2001 • 119 citations

Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene

1999 • 115 citations

Functionally Conserved Xenobiotic Responsive Enhancer in Cytochrome P450 3A7

2001 • 68 citations

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein

1996 • 63 citations

Disodium bis(o-chloranilato)uranyl(VI) hexahydrate

1994 • 12 citations