Dendritic Cells (DC) Activated by CpG DNA Ex Vivo Are Potent Inducers of Host Resistance to an Intracellular Pathogen That Is Independent of IL-12 Derived from the Immunizing DC

Immunobiology of Dendritic Cells

2000 • 6,653 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Mouse and human dendritic cell subtypes

2002 • 2,311 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

Dendritic cell regulation of TH1-TH2 development

2000 • 1,136 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

2000 • 804 citations

The use of dendritic cells in cancer immunotherapy

2003 • 641 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

2002 • 507 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

1998 • 457 citations

Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage

1999 • 430 citations

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major

1997 • 359 citations

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

1998 • 349 citations

Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function

2003 • 347 citations

A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells

2000 • 335 citations

Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection

2003 • 316 citations

CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development

2001 • 287 citations

In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting

2002 • 258 citations

Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection

1998 • 238 citations

Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering

2002 • 231 citations

Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation

2001 • 230 citations

Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms

1999 • 224 citations

Further Checkpoints in Th1 Development

2002 • 206 citations

Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

2000 • 195 citations

The role of antigen and IL-12 in sustaining Th1 memory cellsin vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

2000 • 193 citations

A simple method for quantifying Leishmania in tissues of infected animals

1997 • 172 citations

Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-Term Memory CD4+and CD8+T Cell Responses and Protection Against Leishmania major Infection

2002 • 171 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

Immunostimulatory DNA as an Adjuvant in Vaccination againstLeishmania major

1999 • 144 citations

Dendritic Cell (DC)-Based Protection Against an Intracellular Pathogen Is Dependent Upon DC-Derived IL-12 and Can Be Induced by Molecularly Defined Antigens

2003 • 125 citations

The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals

2002 • 120 citations

Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasiteLeishmania major

1998 • 113 citations

IL-12 Induction by a Th1-Inducing Adjuvant In Vivo: Dendritic Cell Subsets and Regulation by IL-10

2001 • 111 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells

2002 • 82 citations

Dendritic Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides to Act as an Adjuvant for Protective Vaccine Immunity Against Leishmania major in Mice

2003 • 77 citations

Early IL-4 Production Does Not Predict Susceptibility toLeishmania major

1996 • 76 citations

Dendritic Cells Pulsed with a Recombinant Chlamydial Major Outer Membrane Protein Antigen Elicit a CD4⁺Type 2 Rather than Type 1 Immune Response That Is Not Protective

2002 • 68 citations

Rat bone marrow‐derived dendritic cells, but not ex vivo dendritic cells, secrete nitric oxide and can inhibit T‐cell proliferation

2003 • 41 citations

Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response.

1997 • 37 citations

Vaccine delivery strategies

2002 • 24 citations