Ciliary neurotrophic factor

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1991 • 2,763 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.

1992 • 703 citations

Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique

1974 • 651 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Disruption of the CNTF gene results in motor neuron degeneration

1993 • 566 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989 • 429 citations

Cholinergic Neuronotrophic Factors: Intraocular Distribution of Trophic Activity for Ciliary Neurons

1979 • 414 citations

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

1988 • 408 citations

The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

1993 • 402 citations

Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration.

1992 • 365 citations

A crucial role for neurotrophin-3 in oligodendrocyte development

1994 • 353 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture.

1989 • 347 citations

Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain.

1991 • 346 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

1992 • 309 citations

Nerve growth factors in the rat iris

1980 • 297 citations

Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor

1989 • 297 citations

Does oligodendrocyte survival depend on axons?

1993 • 291 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

Cytokine receptors and signal transduction

1992 • 269 citations

Growth and maturation factors

1983 • 269 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

Injury‐induced Regulation of Ciliary Neurotrophic Factor mRNA in the Adult Rat Brain

1993 • 251 citations

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

1988 • 249 citations

Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro

1992 • 246 citations

Synapse formation during embryogenesis on ganglion cells lacking a periphery

1974 • 235 citations

Nerve growth activities in rat peripheral nerve

1982 • 235 citations

Two components from eye tissue that differentially stimulate the growth and development of ciliary ganglion neurons in cell culture

1981 • 235 citations

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

1993 • 230 citations

Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.

1993 • 230 citations

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

1992 • 213 citations

Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

1994 • 213 citations

Brain injury in a dish: a model for reactive gliosis

1994 • 204 citations

Expression of Ciliary Neurotrophic Factor and the Neurotrophins – Nerve Growth Factor, Brain‐Derived Neurotrophic Factor and Neurotrophin 3—in Cultured Rat Hippocampal Astrocytes

1992 • 197 citations

The Neurotrophins BDNF, NT‐3 and NT‐4/5, But Not NGF, Up‐regulate the Cholinergic Phenotype of Developing Motor Neurons

1993 • 192 citations

Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons

1992 • 192 citations

Characterization of two ganglion cell populations in avian ciliary ganglia

1971 • 181 citations

Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia

1976 • 178 citations

The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat

1986 • 175 citations

Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve

1992 • 167 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Competition for survival among developing ciliary ganglion cells

1980 • 163 citations

Ciliary neurotrophic factor: Pharmacokinetics and acute‐phase response in rat

1994 • 162 citations

Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons

1992 • 155 citations

Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development.

1990 • 155 citations

Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease)

1993 • 154 citations

Stimulation of myoblast proliferation in culture by leukaemia inhibitory factor and other cytokines

1991 • 152 citations

Dissociated ciliary ganglion neurons in vitro: survival and synapse formation.

1977 • 147 citations

The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?

1992 • 135 citations

Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.

1993 • 130 citations

Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor.

1994 • 130 citations

Survival and development of ciliary ganglion neurones grown alone in cell culture

1979 • 128 citations

Ciliary neurotrophic factor and its receptor complex

1992 • 128 citations

CELL DEATH IN THE EMBRYONIC CHICK SPINAL CORD

1974 • 127 citations

Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival

1991 • 127 citations

Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation

1992 • 122 citations

Schwann cells: early lineage, regulation of proliferation and control of myelin formation

1992 • 119 citations

Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of Schwannoma and other conditioned media

1982 • 108 citations

Structure‐function analysis of human interleukin‐6

1990 • 107 citations

The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat

1992 • 106 citations

Survival in vitro of motoneurons identified or purified by novel antibodybased methods is selectively enhanced by muscle-derived factors

1991 • 99 citations

Recombinant Human and Rat Ciliary Neurotrophic Factors

1991 • 96 citations

Increased CNTF gene expression in process‐bearing astrocytes following injury is augmented by R(−)‐deprenyl

1994 • 93 citations

Trophic Support of Motoneurons: Physiological, Pathophysiological, and Therapeutic Implications

1993 • 84 citations

Cloning, expression during development, and evidence for release of a trophic factor for ciliary ganglion neurons

1992 • 84 citations

Effects of ciliary neuronotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low-affinity nerve growth factor receptors

1991 • 84 citations

Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: Effects of the ChAT development factor, CDF

1990 • 83 citations

Ciliary neurotrophic factor induces acute‐phase protein expression in hepatocytes

1992 • 81 citations

Purification of a skeletal muscle polypeptide which stimulates choline acetyltransferase activity in cultured spinal cord neurons.

1988 • 75 citations

The three carboxy‐terminal amino acids of human interleukin‐6 are essential for its biological activity

1990 • 75 citations

Neuronal adjustments in developing nuclear centers of the chick embryo following transplantation of an additional optic primordium

1978 • 70 citations

High ciliary neuronotrophic specific activity in rat peripheral nerve

1984 • 67 citations

Neurite outgrowth elicited by embryonic chick heart: Partial purification of the active factor

1979 • 64 citations

Sequence and structural organization of the human gene encoding ciliary neurotrophic factor

1991 • 63 citations

Ciliary neurotrophic factor is an endogenous pyrogen.

1993 • 59 citations

Evidence for the importance of a positive charge and an α‐helical structure of the C‐terminus for biological activity of human IL‐6

1991 • 56 citations

Exchange of a single amino acid interconverts the specific activity and gel mobility of human and rat ciliary neurotrophic factors.

1993 • 56 citations

Localization of CNTF immunoreactivity to neurons and astroglia in the CNS

1994 • 55 citations

Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra

1993 • 54 citations

Ectopic trkA expression mediates a NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons.

1993 • 53 citations

Effects of the Neurotrophins and CNTF on Developing Statoacoustic Neurons: Comparison with an Otocyst-Derived Factor

1993 • 53 citations

Isolation and characterization of ciliary neurotrophic factor from rabbit sciatic nerves.

1990 • 52 citations

Purification of a Ciliary Neurotrophic Factor from Bovine Heart

1987 • 50 citations

Decreased synthesis of ciliary neurotrophic factor in degenerating peripheral nerves

1992 • 49 citations

The innervation of chick striated muscle fibers by the chick ciliary ganglion in tissue culture

1975 • 47 citations

Cholinergic growth factor from skeletal muscle elevated following denervation

1983 • 45 citations

Regulation of Ciliary Neurotrophic Factor in Cultured Rat Hippocampal Astrocytes

1994 • 43 citations

Rat ciliary neurotrophic factor (CNTF): Gene structure and regulation of mRNA levels in glial cell cultures

1993 • 43 citations

Ciliary neurotrophic factor (CNTF) promotes low-affinity nerve growth factor receptor and CD4 expression by rat CNS microglia

1993 • 41 citations

The formation of synapses between chick embryo skeletal muscle and ciliary ganglia grown in vitro.

1976 • 39 citations

Cooperative Effects of Ciliary Neurotrophic Factor and Norepinephrine on Tyrosine Hydroxylase Expression in Cultured Rat Locus Coeruleus Neurons

1993 • 38 citations

Synthesis, purification, and characterization of human ciliary neuronotrophic factor from E. coli

1991 • 37 citations

Cholinergic Neuronotrophic Factors. Concurrent Activities on Certain Nerve Growth Factor‐Responsive Neurons

1982 • 36 citations

Disulfide bond assignment and identification of regions required for functional activity of oncostatin M

1991 • 35 citations

An effect of nerve growth factor on the parasympathetic ciliary ganglion

1984 • 35 citations

CNTF promotes the survival of neonatal rat corticospinal neurons in vitro

1993 • 33 citations

Differential labeling of the cell surface of single ciliary ganglion neurons in vitro.

1976 • 27 citations

Recombinant human ciliary neurotrophic factor alters the threshold of hippocampal pyramidal neuron sensitivity to excitotoxin damage: Synergistic effects of monosialogangliosides

1992 • 26 citations

Ciliary Neurotrophic Factor Regulates Fibrinogen Gene Expression in Hepatocytes by Binding to the Interleukin-6 Receptor

1993 • 26 citations

Comparative Binding of Neurotrophins (NT-3, CNTF and NGF) and Various Cytokines to α2-Macroglobulin

1993 • 24 citations

Characterisation of high‐affinity and low‐affinity receptors for ciliary neurotrophic factor

1993 • 20 citations

Chick ciliary ganglion in dissociated cell culture

1982 • 19 citations

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease ‘Wobbler’ of the Mouse

1991 • 16 citations

Chromosomal localization of the human ciliary neurotrophic factor gene (CNTF) to 11q12 by fluorescence in situ hybridization

1993 • 10 citations

Partial purification of a parasympathetic neurotrophic factor in pig lung

1987 • 8 citations

Structure-function studies of human ciliary neurotrophic factor

1994 • 8 citations