Inflammation and Atherosclerosis

Inflammation in atherosclerosis

2002 • 7,873 citations

Beyond Cholesterol

1989 • 6,533 citations

Atherosclerosis

2001 • 2,982 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention

2003 • 2,434 citations

Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

2000 • 1,945 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

Statins as a newly recognized type of immunomodulator

2000 • 1,371 citations

Inflammation as a Cardiovascular Risk Factor

2004 • 1,256 citations

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

1998 • 1,238 citations

A Self-Fulfilling Prophecy

2002 • 1,039 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Monocyte chemoattractant protein-1 in human atheromatous plaques.

1991 • 892 citations

Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

1991 • 879 citations

Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells

2002 • 854 citations

C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

2001 • 853 citations

Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

2001 • 839 citations

Immune mechanisms in atherosclerosis.

1989 • 827 citations

The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis

1993 • 772 citations

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

1997 • 751 citations

Novel Clinical Markers of Vascular Wall Inflammation

2001 • 750 citations

The Yin and Yang of Oxidation in the Development of the Fatty Streak

1996 • 705 citations

Mouse Models of Atherosclerosis

1996 • 701 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein

2002 • 641 citations

C-Reactive Protein in the Arterial Intima

2000 • 590 citations

Leucocyte-endothelial interactions and regulation of leucocyte migration

1994 • 584 citations

Roles of Infectious Agents in Atherosclerosis and Restenosis

1997 • 566 citations

Soluble P-Selectin and the Risk of Future Cardiovascular Events

2001 • 560 citations

C-Reactive Protein Upregulates Angiotensin Type 1 Receptors in Vascular Smooth Muscle

2003 • 549 citations

Dendritic cells: emerging pharmacological targets of immunosuppressive drugs

2004 • 538 citations

Chemokines and atherosclerosis

1999 • 510 citations

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

1998 • 471 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

Disruption of TGF-β signaling in T cells accelerates atherosclerosis

2003 • 426 citations

C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice

2004 • 380 citations

Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis

1993 • 332 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment

2000 • 301 citations

Induction of a Regulatory T Cell Type 1 Response Reduces the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice

2003 • 296 citations

Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody

1993 • 272 citations

Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice

1999 • 266 citations

Chemokines: Roles in leukocyte development, trafficking, and effector function

2003 • 259 citations

Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions

1998 • 238 citations

Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration.

1991 • 232 citations

Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates.

1992 • 223 citations

Coronary Heart Disease: Reducing the Risk

1999 • 221 citations

Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.

1993 • 217 citations

Altered Pattern of Vascular Connexin Expression in Atherosclerotic Plaques

2002 • 207 citations

Nicotine Strongly Activates Dendritic Cell–Mediated Adaptive Immunity

2003 • 205 citations

Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice

2000 • 203 citations

Lipid Lowering Reduces Oxidative Stress and Endothelial Cell Activation in Rabbit Atheroma

2002 • 202 citations

CD40-CD40L Interactions in Atherosclerosis

2002 • 185 citations

S-100 positive cells in human arterial intima and in atherosclerotic lesions

1995 • 181 citations

C-reactive protein and interleukin-6 in vascular disease

2003 • 178 citations

Ultrastructural Recognition of Cells with Dendritic Cell Morphology in Human Aortic Intima. Contacting Interactions of Vascular Dendritic Cells in Athero-resistant and Athero-prone Areas of the Normal Aorta.

1995 • 177 citations

Effects of transforming growth factor-beta 1 on human arterial smooth muscle cells in vitro.

1991 • 171 citations

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions

2003 • 159 citations

Reduced Connexin43 Expression Inhibits Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice

2003 • 155 citations

Specific abrogation of transforming growth factor-β signaling in T cells alters atherosclerotic lesion size and composition in mice

2003 • 146 citations

Human Vascular Smooth Muscle Cells Express Receptors for CC Chemokines

1998 • 138 citations

Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells

2003 • 137 citations

Upregulation of Connexin43 Gap Junctions During Early Stages of Human Coronary Atherosclerosis

1995 • 126 citations

P-Selectin and Vascular Cell Adhesion Molecule-1 Are Focally Expressed in Aortas of Hypercholesterolemic Rabbits Before Intimal Accumulation of Macrophages and T Lymphocytes

1997 • 119 citations

Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function

1999 • 112 citations

Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

2002 • 110 citations

Statins: the new aspirin?

2002 • 109 citations

CD154 (CD40 ligand)

2000 • 105 citations

Endothelial Determinants of Dendritic Cell Adhesion and Migration

2002 • 102 citations

The role of transforming growth factor beta in atherosclerosis: novel insights and future perspectives

2002 • 90 citations

Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions.

1993 • 86 citations

Transforming Growth Factor-β1 Inhibits Macrophage Cholesteryl Ester Accumulation Induced by Native and Oxidized VLDL Remnants

2001 • 83 citations

Transforming growth factor β decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase

1994 • 82 citations

Connexin43 Gene Expression in the Rabbit Arterial Wall: Effects of Hypercholesterolemia, Balloon Injury and Their Combination

1997 • 81 citations

Oxidized low density lipoprotein and very low density lipoprotein enhance expression of monocyte chemoattractant protein-1 in rabbit peritoneal exudate macrophages

1997 • 73 citations

Connexins in leukocytes: shuttling messages?

2004 • 46 citations

Induction of human endothelial cell growth by mildly oxidized low density lipoprotein

1996 • 29 citations