Metabolic alterations common to neural and non‐neural cells in alzheimer's disease

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1988 • 406 citations

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1983 • 355 citations

Biochemistry and the Central Nervous System

1972 • 346 citations

Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type

1980 • 254 citations

Enzyme Activities in Relation to pH and Lactate in Postmortem Brain in Alzheimer‐Type and Other Dementias

1990 • 252 citations

Brain dysfunction in mild to moderate hypoxia

1981 • 252 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

1980 • 232 citations

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.

1986 • 218 citations

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

1992 • 215 citations

Mitochondrial function in brain tissue in primary degenerative dementia

1987 • 177 citations

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1990 • 168 citations

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

1985 • 164 citations

Evidence for mitochondrial DNA damage by lipid peroxidation

1988 • 160 citations

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

1991 • 159 citations

High-resolution PET studies in Alzheimer's disease.

1991 • 156 citations

Glucocorticoids Exacerbate Hypoxic and Hypoglycemic Hippocampal Injury In Vitro: Biochemical Correlates and a Role for Astrocytes

1992 • 137 citations

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

1992 • 137 citations

Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation

1990 • 136 citations

Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.

1986 • 135 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

Metabolic Processes in Alzheimer's Disease: Adenine Nucleotide Content and Production of ¹⁴CO₂ from [U‐¹⁴C]Glucose In Vitro in Human Neocortex

1983 • 126 citations

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1987 • 121 citations

Abnormalities of Glucose Metabolism in Alzheimer's Disease

1991 • 109 citations

Reduced Protein Kinase C Immunoreactivity and Altered Protein Phosphorylation in Alzheimer's Disease Fibroblasts

1989 • 100 citations

Adenylyl Cyclase Activity in Postmortem Human Brain: Evidence of Altered G Protein Mediation in Alzheimer's Disease

1992 • 96 citations

Quantitative EEG mapping and PET in Alzheimer's disease

1992 • 88 citations

Assessing Utility of Single Photon Emission Computed Tomography (SPECT) Scan in Alzheimer Disease

1990 • 86 citations

Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.

1991 • 85 citations

Cytochrome Oxidase Deficiency in Alzheimer's Diseasea

1991 • 79 citations

Decreased adhesiveness of alzheimer's disease fibroblasts: Is amyloid β‐protein precursor involved?

1989 • 79 citations

Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

1991 • 78 citations

Neurotoxicity of ammonia and fatty acids: Differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acyl coenzyme a derivatives

1991 • 76 citations

Altered response of fibroblasts from aged and Alzheimer donors to drugs that elevate cytosolic free calcium

1988 • 73 citations

Spin label and biochemical studies of erythrocyte membranes in Alzheimer's disease

1980 • 73 citations

Erythrocyte membrane characteristics indicate abnormal cellular aging in patients with Alzheimer's disease

1991 • 72 citations

The Activities of Some Energy‐Metabolising Enzymes in Nonsynaptic (Free) and Synaptic Mitochondria Derived from Selected Brain Regions

1984 • 65 citations

Increased immunoreactivity of brain spectrin in Alzheimer disease: a marker for synapse loss?

1990 • 63 citations

Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytes

1992 • 61 citations

The Cellular Basis of Delirium and Its Relevance to Age-Related Disorders Including Alzheimer's Disease

1991 • 61 citations

Diminished mitogen-induced calcium uptake by lymphocytes from alzheimer patients

1987 • 57 citations

Is a point mutation in the mitochondrial ND2 gene associated with alzheimer's disease?

1992 • 55 citations

NUCLEOSIDE PHOSPHATASE ACTIVITIES ASSOCIATED WITH THE TANGLES AND PLAQUES OF ALZHEIMERʼS DISEASE

1970 • 54 citations

Reorganization of HeLa cell cytoskeleton induced by an uncoupler of oxidative phosphorylation

1982 • 54 citations

Light microscopic immunocytochemical localization of pyruvate dehydrogenase complex in rat brain: topographical distribution and relation to cholinergic and catecholaminergic nuclei

1987 • 48 citations

Niemann‐Pick type‐C disease: Deficient intracellular transport of exogenously derived cholesterol

1992 • 47 citations

Cytochrome aa3 depletion is the cause of the deficient mitochondrial respiration induced by chronic valproate administration

1992 • 45 citations

Studies of Transketolase Abnormality in Alzheimer's Disease

1988 • 44 citations

Partial cytochrome c oxidase deficiency and cytoplasmic bodies in patients with zidovudine myopathy

1991 • 43 citations

Metabolic inhibitors and intermediate filament organization in human fibroblasts

1988 • 41 citations

Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts

1991 • 39 citations

Membrane fluidity of platelets and erythrocytes in patients with Alzheimer's disease and the effect of small amounts of aluminium on platelet and erythrocyte membranes

1992 • 38 citations

Nonneural Markers in Alzheimer Disease

1992 • 38 citations

Animal and drug modelling for Alzheimer synaptic pathology

1992 • 37 citations

Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors

1991 • 37 citations

No evidence for reduced thrombocyte cytochrome oxidase activity in Alzheimer's disease

1992 • 34 citations

Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency

1989 • 34 citations

Resting [Ca2+]i and [Ca2+]i transients are similar in fibroblasts from normal and Alzheimer's donors

1992 • 33 citations

L‐Phosphoserine, a Metabolite Elevated in Alzheimer's Disease, Interacts with Specific L‐Glutamate Receptor Subtypes

1991 • 33 citations

Expression of 'Alzheimer Antigens' in Cultured Skin Fibroblasts

1991 • 27 citations

The molecular pathology of amyloid deposition in Alzheimer's disease

1991 • 26 citations

Enhanced proteolytic activities in cultured fibroblasts of Alzheimer patients are revealed by peculiar transketolase alterations

1991 • 21 citations

Cultured Cells as a Screen for Novel Treatments of Alzheimer's Disease

1989 • 17 citations

Philothermal response, microtubules and dementia

1986 • 14 citations

Thiamin and Alzheimer's Disease

1992 • 14 citations

Brain Regional Analysis of NADH-Cytochrome C Reductase Activity in Alzheimerʼs Disease

1990 • 13 citations

Presence of typical neuronal markers in serially cultured cells from adult human brain

1992 • 13 citations

Delayed microtubule reappearance in skin fibroblasts of Alzheimer patients: Preliminary report

1989 • 8 citations

Epinephrine-induced cyclic AMP production in skin fibroblasts from patients with dementia of Alzheimer type and controls

1985 • 8 citations