Renewal of photoreceptor outer segments and their phagocytosis by theretinal pigment epithelium

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS

1969 • 1,156 citations

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle

1998 • 896 citations

Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation

1997 • 882 citations

Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration

1997 • 861 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

1997 • 804 citations

INHERITED RETINAL DYSTROPHY IN THE RAT

1962 • 804 citations

Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor

1990 • 715 citations

Circadian Rhythms in Cultured Mammalian Retina

1996 • 710 citations

Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina.

1993 • 662 citations

Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.

1975 • 595 citations

THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RAT

1971 • 540 citations

Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat Chimeras

1976 • 534 citations

Retinopathy induced in mice by targeted disruption of the rhodopsin gene

1997 • 527 citations

Visual cells and the concept of renewal.

1976 • 484 citations

Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

1994 • 403 citations

Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications

1992 • 399 citations

Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)

1989 • 399 citations

Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies.

1978 • 394 citations

Disc morphogenesis in vertebrate photoreceptors

1980 • 394 citations

A three-base-pair deletion in the peripherin–RDS gene in one form of retinitis pigmentosa

1991 • 381 citations

The ultrastructure of the outer segments of rods and cones of the eye as revealed by the electron microscope

1953 • 359 citations

THE RENEWAL OF ROD AND CONE OUTER SEGMENTS IN THE RHESUS MONKEY

1971 • 351 citations

Inherited retinal dystrophy in the RCS rat: Prevention of photoreceptor degeneration by pigment epithelial cell transplantation

1988 • 329 citations

HEREDITARY DEGENERATION OF THE RAT RETINA

1938 • 311 citations

Peripherin. A rim-specific membrane protein of rod outer segment discs.

1987 • 300 citations

Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration.

1992 • 297 citations

Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase

1983 • 293 citations

Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina.

1984 • 267 citations

Methoxyindoles and Photoreceptor Metabolism: Activation of Rod Shedding

1983 • 265 citations

Chapter 10 Functional roles of dopamine in the vertebrate retina

1991 • 254 citations

A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture.

1995 • 250 citations

Defective Phagocytosis of Isolated Rod Outer Segments by RCS Rat Retinal Pigment Epithelium in Culture

1977 • 247 citations

Retinal dystrophy in the rat--a pigment epithelial disease.

1969 • 242 citations

Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors.

1989 • 241 citations

Experimental Retinal Detachment in the Owl Monkey

1968 • 234 citations

Circadian rhythmicity in vertebrate retinas: Regulation by a photoreceptor oscillator

1995 • 225 citations

The retinal pigment epithelium

1980 • 222 citations

The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration

1998 • 222 citations

CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium

1996 • 220 citations

Retinal detachment in the cat: the pigment epithelial-photoreceptor interface.

1983 • 219 citations

The retinal pigmented epithelium is required for development and maintenance of the mouse neural retina

1995 • 217 citations

Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.

1994 • 214 citations

Mammalian cones: disc shedding, phagocytosis, and renewal.

1978 • 209 citations

Organization of pyramidal neurons in area 17 of monkey visual cortex

1991 • 209 citations

STUDIES ON THE ENDOPLASMIC RETICULUM

1960 • 207 citations

Circadian nature of rod outer segment disc shedding in the rat.

1980 • 204 citations

The daily rhythm of shedding and degradation of rod and cone outer segment membranes in the chick retina.

1978 • 193 citations

KINETICS OF ROD OUTER SEGMENT RENEWAL IN THE DEVELOPING MOUSE RETINA

1973 • 192 citations

Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro.

1980 • 191 citations

Signal transduction of phagocytosis

1995 • 190 citations

Evidence for a Distinct D₁Like Dopamine Receptor that Couples to Activation of Phosphoinositide Metabolism in Brain

1994 • 187 citations

Retinal pigmented epithelial cells induced to transdifferentiate to neurons by laminin

1987 • 183 citations

Vesicular transport of newly synthesized opsin from the Golgi apparatus toward the rod outer segment. Ultrastructural immunocytochemical and autoradiographic evidence in Xenopus retinas.

1985 • 182 citations

Histologic Features of the Early Stages of Age-related Macular Degeneration

1992 • 176 citations

The rd mouse story: Seventy years of research on an animal model of inherited retinal degeneration

1994 • 173 citations

Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy

1983 • 168 citations

The Fine Structure of Some Retinal Photoreceptors

1960 • 161 citations

Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.

1987 • 161 citations

The Visual Input Stage of the Mammalian Circadian Pacemaking System: I. Is There a Clock in the Mammalian Eye?

1991 • 158 citations

Retinal transmitters and modulators : models for the brain

1985 • 153 citations

Adenylyl cyclases: structure, regulation and function in an enzyme superfamily

1997 • 151 citations

Ganglion cell loss in RCS rat retina: A result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium

1998 • 150 citations

Photoreceptor Degeneration in Vitamin A Deprivation and Retinitis Pigmentosa: the Equivalent Light Hypothesis

1993 • 150 citations

The daily rhythm of shedding and degradation of cone outer segment membranes in the lizard retina

1977 • 144 citations

Rhythmic daily shedding of outer-segment membranes by visual cells in the goldfish.

1978 • 142 citations

Binding of Anionic Phospholipids to Retinal Pigment Epithelium May Be Mediated by the Scavenger Receptor CD36

1996 • 142 citations

Circadian rhythm in rat retinal dopamine

1984 • 139 citations

Evidence for both local and central regulation of rat rod outer segment disc shedding.

1980 • 137 citations

Pigmented retinal epithelium involvement in photoreceptor development and function

1974 • 134 citations

Outer Segments of Photoreceptors and the Retinal Pigment Epithelium

1970 • 134 citations

Differentiation and Transdifferentiation of the Retinal Pigment Epithelium

1997 • 134 citations

Rat retinal pigment epithelial cells show specificity of phagocytosis in vitro.

1986 • 132 citations

Muller cells of chicken retina synthesize 11-cis-retinol

1992 • 130 citations

The ultrastructure of the pigment epithelium and of the photoreceptor-pigment epithelium junction in the human retina

1963 • 129 citations

Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant-deficient rats.

1978 • 128 citations

HORMONAL CONTROL OF LYSOSOMAL ENZYME RELEASE FROM HUMAN NEUTROPHILS

1974 • 124 citations

Myosin VIIa as a common component of cilia and microvilli

1998 • 123 citations

Subunit Composition of the Peripherin/rds−Rom-1 Disk Rim Complex from Rod Photoreceptors: Hydrodynamic Evidence for a Tetrameric Quaternary Structure

1996 • 122 citations

Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1

1996 • 119 citations

Cysteine Residues of Photoreceptor Peripherin/rds: Role in Subunit Assembly and Autosomal Dominant Retinitis Pigmentosa

1998 • 115 citations

Embryology of the human eye

1955 • 113 citations

Actin in the photoreceptor connecting cilium: immunocytochemical localization to the site of outer segment disk formation.

1984 • 112 citations

Rod outer segment disk shedding in rats with lesions of the suprachiasmatic nucleus

1993 • 110 citations

Age-related changes in the retinal pigment epithelium of pigmented rats

1984 • 110 citations

Localization of Adenosine Receptor Messenger RNAs in the Rat Eye

1997 • 108 citations

Vertebrate photoreceptor cell development and disease

1998 • 108 citations

Phagocytosis in the Retinal Pigment Epithelium of the RCS Rat

1978 • 108 citations

Heterologous Expression of Photoreceptor Peripherin/rds and Rom-1 in COS-1 Cells: Assembly, Interactions, and Localization of Multisubunit Complexes

1995 • 106 citations

An improved method for isolation and culture of rat retinal pigment epithelial cells.

1985 • 105 citations

Dynamic condition of proteins in the visual cells of rats and mice as shown by radioautography with labeled amino acids

1963 • 104 citations

Dopaminergic mechanisms in vision

1989 • 99 citations

Chapter 9 Structure, composition and function of the retinal interphotoreceptor matrix

1991 • 98 citations

An in vitro model of phagocytosis in bovine and human retinal pigment epithelium

1976 • 97 citations

Phagocytosis by pigment epithelium of human retinal cones

1974 • 96 citations

Retinal pigment epithelium possesses both LDL and scavenger receptor activity.

1989 • 93 citations

The Retina a Model for Cell Biology Studies

1986 • 93 citations

Photoreceptor dystrophy in the RCS rat: roles of oxygen, debris, and bFGF.

1998 • 91 citations

The effects of hibernation on cone visual cells in the ground squirrel.

1977 • 90 citations

Localisation of neuronal nitric oxide synthase-immunoreactivity in rat and rabbit retinas

1995 • 90 citations

Nitric oxide modulates endogenous dopamine release in bovine retina

1994 • 89 citations

Evidence from normal and degenerating photoreceptors that two outer segment integral membrane proteins have separate transport pathways

1997 • 88 citations

Kinetic studies of rod outer segment binding and ingestion by cultured rat RPE cells

1987 • 87 citations

Possible roles of microtubules and actin filaments in retinal pigmented epithelium

1976 • 86 citations

PHOTOSENSITIVE MEMBRANE TURNOVER: DIFFERENTIATED MEMBRANE DOMAINS AND CELL-CELL INTERACTION

1986 • 86 citations

Molecular cloning, membrane topology, and localization of bovine rom-1 in rod and cone photoreceptor cells.

1996 • 84 citations

Chapter 10 Improved methodology for cell culture of human and monkey retinal pigment epithelium

1991 • 84 citations

Circadian rhythm in the light response of rat retinal disk-shedding and autophagy

1986 • 83 citations

Senescence of the retinal pigmented epithelium.

1999 • 82 citations

The role of melatonin and dopamine in retinal physiology

1980 • 81 citations

The photoreceptors of diurnal squirrels: Outer segment structure, disc shedding, and protein renewal

1976 • 81 citations

Chapter 6 Ageing of the retinal pigment epithelium

1991 • 81 citations

Effects of exogenous melatonin on circadian disc shedding in the albino rat retina

1989 • 80 citations

The photoreceptors and pigment epithelium of the larvalXenopusretina: morphogenesis and outer segment renewal

1978 • 79 citations

Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes

1996 • 79 citations

Integrin alphavbeta5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium.

1998 • 78 citations

Phagocytic Activity of Cultured Retinal Pigment Epithelial Cells from Chick Embryo: Inhibition by Melatonin and Cyclic AMP, and Its Reversal by Taurine and Cyclic GMP

1983 • 78 citations

The Degradation of the Photoreceptor Outer Segment within the Pigment Epithelial Cell of Rat Retina<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1970 • 78 citations

Retinal pigment epithelial transplants and retinal function in RCS rats.

1993 • 77 citations

An improved method for isolation and culture of pigment epithelial cells from rat retina

1991 • 77 citations

Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons

1995 • 76 citations

Evidence against the role of rhodopsin in rod outer segment binding to RPE cells.

1988 • 74 citations

Immunophagocytic Properties of Retinal Pigment Epithelium Cells

1981 • 74 citations

Dopamine Inhibits Melatonin Synthesis in Photoreceptor Cells Through a D₂‐Like Receptor Subtype in the Rat Retina: Biochemical and Histochemical Evidence

1996 • 73 citations

Apical polarization of N-CAM in retinal pigment epithelium is dependent on contact with the neural retina.

1993 • 73 citations

The role of GABA in the regulation of the dopamine/tyrosine hydroxylase-containing neurons of the rat retina

1981 • 72 citations

Rod and cone disc shedding in the rhesus monkey retina: A quantitative study

1980 • 72 citations

Turnover of rod photoreceptor outer segments. I. Membrane addition and loss in relationship to temperature.

1977 • 71 citations

Localization of D₂ dopamine receptors in vertebrate retinae with anti‐peptide antibodies

1993 • 71 citations

ROS ingestion by RPE cells is turned off by increased protein kinase C activity and by increased calcium

1991 • 70 citations

The Visual Input Stage of the Mammalian Circadian Pacemaking System: II. The Effect of Light and Drugs on Retinal Function

1991 • 70 citations

Isolation and characterization of a mannose receptor from human pigment epithelium.

1991 • 69 citations

Beta adrenergic receptors on cultured human retinal pigment epithelium.

1990 • 68 citations

Tissue culture of human retinal pigment epithelium.

1973 • 68 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

Fine structure of the pigment epithelium in the vertebrate retina.

1978 • 66 citations

Discrete Distributions of Adenosine Receptors in Mammalian Retina

1990 • 66 citations

Improvement of the Pupillary Light Reflex of Royal College of Surgeons Rats Following RPE Cell Grafts

1996 • 64 citations

Prevention of rod disk shedding by detachment from the retinal pigment epithelium.

1987 • 64 citations

Mechanism of retinal ganglion cell loss in inherited retinal dystrophy

1996 • 64 citations

Immunohistochemical localization of transforming growth factor-βin human photoreceptors

1991 • 63 citations

Both rod and cone disc shedding are related to light onset in the cat.

1983 • 62 citations

An hypothesis to account for a basic distinction between rods and cones

1971 • 62 citations

Vitronectin receptor expression and distribution at the photoreceptor‐retinal pigment epithelial interface

1995 • 62 citations

Immunohistochemical evidence for epinephrine-containing retinal amacrine cells

1984 • 61 citations

THE MECHANISM OF PHAGOCYTOSIS

1982 • 61 citations

Dorsal raphe serotonergic projection to the retina. A combined peroxidase tracing-neurochemical/high-performance liquid chromatography study in the rat

1987 • 60 citations

Actin filaments in apical projections of the primate pigmented epithelial cell.

1976 • 60 citations

The distribution of actin in cultured normal and dystrophic rat pigment epithelial cells during the phagocytosis of rod outer segments.

1983 • 60 citations

Lipopolysaccharide and cytokines induce a macrophage-type of nitric oxide synthase in bovine retinal pigmented epithelial cells

1992 • 60 citations

RPE conditioned medium stimulates photoreceptor cell survival, neurite outgrowth and differentiation in vitro

1992 • 58 citations

Photoreceptor shedding can be initiated within the eye

1978 • 58 citations

Fibroblast growth factor receptor deficiency in dystrophic retinal pigmented epithelium

1993 • 57 citations

Pigment epithelium-photoreceptor interactions in the normal and dystrophic rat retina

1975 • 57 citations

Nitric oxide decreases in vitro phagocytosis of photoreceptor outer segments by bovine retinal pigmented epithelial cells

1994 • 55 citations

Transforming growth factor-β regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway

1994 • 55 citations

Müller cell changes precede vascularization of the pigment epithelium in the dystrophic rat retina

1990 • 55 citations

Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry

1995 • 54 citations

Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells.

1995 • 53 citations

Signal transduction from the extracellular matrix: the integrin-tyrosine kinase connection

1992 • 53 citations

Components of the cytoskeleton in the retinal pigmented epithelium of the chick.

1985 • 53 citations

Membrane turnover in rod photoreceptors: ensheathment and phagocytosis of outer segment distal tips by pseudopodia of the retinal pigment epithelium

1987 • 53 citations

Photoreceptor outer segment development: light and dark regulate the rate of membrane addition and loss.

1979 • 53 citations

The pineal gland does not control rod outer segment shedding and phagocytosis in the rat retina and pigment epithelium.

1978 • 53 citations

Vitronectin is responsible for serum-stimulated uptake of rod outer segments by cultured retinal pigment epithelial cells.

1997 • 51 citations

The relationship of primate foveal cones to the pigment epithelium

1979 • 51 citations

Stimulation of photoreceptor disc shedding and pigment epithelial phagocytosis by glutamate, aspartate, and other amino acids

1985 • 50 citations

Bovine retinal pigment epithelial cells cultured in vitro: Growth characteristics, morphology, chromosomes, phagocytosis ability, tyrosinase activity and effect of freezing

1983 • 50 citations

The role of dopamine in the regulation of melatonin biosynthesis in vertebrate retina.

1994 • 50 citations

Role of melatonin in retina

1988 • 50 citations

Localization of mRNA encoding the indolamine synthesizing enzyme, hydroxyindole-O-methyltransferase, in chicken pineal gland and retina by in situ hybridization

1993 • 49 citations

Intraretinal transplantation of fluorescently labeled retinal cell suspensions

1988 • 48 citations

Stimulation of A2 adenosine receptors inhibits the ingestion of photoreceptor outer segments by retinal pigment epithelium.

1994 • 48 citations

Human retinal pigment epithelial cells possess muscarinic receptors coupled to calcium mobilization

1988 • 48 citations

Detection and possible functions of a cysteine protease involved in digestion of rod outer segments by retinal pigment epithelial cells.

1994 • 48 citations

The early appearance of disc shedding in the rat retina.

1979 • 48 citations

Light and temperature modulated staining of the rod outer segment distal tips with Lucifer yellow.

1985 • 48 citations

Phagocytosis of outer segments by cultured rat pigment epithelium. Reduction by cyclic AMP and phosphodiesterase inhibitors.

1980 • 47 citations

[9] Preparation and characterization of sealed bovine rod cell outer segments

1982 • 47 citations

Kinetic Studies on Phagocytosis and Lysosomal Digestion of Rod Outer Segments by Human Retinal Pigment Epithelial Cells in Vitro

1994 • 47 citations

Corneal electroretinographic function rescued by normal retinal pigment epithelial grafts in retinal degenerative Royal College of Surgeons rats.

1994 • 46 citations

Taurine fluxes in isolated cat and rat retinas: Effects of illumination

1978 • 44 citations

Cloning and localization of RPE65 mRNA in salamander cone photoreceptor cells

1998 • 43 citations

Phagocytic activity in the retinal pigment epithelium of the frog Rana pipiens

1974 • 43 citations

Human retinal pigment epithelial cells in culture possess A2-adenosine receptors

1989 • 43 citations

The phagocytosis of rod outer segments is inhibited by drugs linked to cyclic adenosine monophosphate production.

1993 • 42 citations

Phagocytosis by retinal pigment epithelium explants in culture

1981 • 42 citations

Peripherin/rds and rom-1: Molecular properties and role in photoreceptor cell degeneration

1994 • 42 citations

Membraneous inclusions in the retinal pigment epithelium: phagosomes and myeloid bodies.

1971 • 42 citations

Thetau mutation shortens the period of rhythmic photoreceptor outer segment disk shedding in the hamster

1996 • 41 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment decreases dopamine and increases lipofuscin in mouse retina

1986 • 41 citations

Release of γ‐Amino[³H]butyric Acid from Cultured Amacrine‐Like Neurons Mediated by Different Excitatory Amino Acid Receptors

1991 • 41 citations

The isolation and culturing of retinal pigment epithelium of the rat

1981 • 41 citations

Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium.

1998 • 41 citations

Retinal pigment epithelium in culture demonstrates a distinct β-adrenergic receptor

1984 • 41 citations

Characterization of retinal pigment epithelial cells cultured on microporous filters

1987 • 40 citations

Inositol triphosphate generation in cultured rat retinal pigment epithelium.

1994 • 40 citations

Dihydropyridine-sensitive calcium currents in freshly isolated human and monkey retinal pigment epithelial cells.

1995 • 39 citations

THE CELL BIOLOGY OF THE RETINAL PIGMENT EPITHELIUM

1986 • 39 citations

Characterization of adenylate cyclase in human retinal pigment epithelial cells in vitro

1987 • 39 citations

Catecholaminergic binding sites in cat retina, pigment epithelium and choroid

1986 • 39 citations

Double fluorescent vital assay of phagocytosis by cultured retinal pigment epithelial cells.

1993 • 39 citations

Retinal dystrophy in the RCS rat: in vivo and in vitro studies of phagocytic action of the pigment epithelium on the shed rod outer segments

1979 • 39 citations

Research in Retinitis Pigmentosa

1989 • 38 citations

Nitric oxide inhibits depolarization-induced release of endogenous dopamine in the rabbit retina

1995 • 38 citations

Phagocytic capabilities of the pigment epithelium

1976 • 38 citations

The neural retina maintains integrins in the apical membrane of the RPE early in development.

1994 • 38 citations

Lipofuscin in the Retina: Quantitative Assay for an Unprecedented Autofluorescent Compound (Pyridinium Bis-Retinoid, A2-E) of Ocular Age Pigment

1997 • 38 citations

Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations

1996 • 38 citations

Expression of Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Receptors and PACAP in Human Fetal Retina

1997 • 38 citations

Localization of retinal calmodulin kinase

1988 • 37 citations

Receptor‐Coupled Phosphoinositide Hydrolysis in Human Retinal Pigment Epithelium

1991 • 37 citations

Centrifugal innervation of the rat retina

1995 • 36 citations

Melatonin and 5-hydroxytryptamine phase-advance the rat circadian clock by activation of nitric oxide synthesis

1996 • 36 citations

Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats.

1991 • 36 citations

RPE transplants stabilize retinal vasculature and prevent neovascularization in the RCS rat.

1992 • 36 citations

Molecular identification of a dopamine D1b receptor in bovine retinal pigment epithelium

1997 • 35 citations

Superoxide Inhibits Proliferation and Phagocytic Internalization of Photoreceptor Outer Segments by Bovine Retinal Pigment Epithelium in Vitro

1994 • 34 citations

Rhodopsin Replacement Rescues Photoreceptor Structure during a Critical Developmental Window

1997 • 33 citations

Rod and cone disc shedding in light-entrained tree squirrels

1980 • 33 citations

Selective Transcription Factor Induction in Retinal Pigment Epithelial Cells during Photoreceptor Phagocytosis

1996 • 33 citations

Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice

1976 • 32 citations

Neuropeptide Y and the retinal pigment epithelium: receptor subtypes, signaling, and bioelectrical responses.

1998 • 32 citations

Characterization of Adenosine A2 Receptors in Bovine Retinal Pigment Epithelial Membranes

1993 • 32 citations

Light stimulates in vivo inositol lipid turnover in frog retinal pigment epithelial cells at the onset of shedding and phagocytosis of photoreceptor membranes

1992 • 32 citations

Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

1991 • 31 citations

Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium.

1999 • 31 citations

Association of changes in intracellular cyclic AMP with changes in phagocytosis in cultured rat pigment epithelium

1986 • 31 citations

Fluorescence properties of autofluorescent granules generated by cultured human RPE cells.

1998 • 30 citations

Serotonergic, 5-HT2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells

1993 • 30 citations

Inherited retinal degeneration: basic FGF induces phagocytic competence in cultured RPE cells from RCS rats

1997 • 30 citations

Protein phosphorylation in retinal pigment epithelium of Long-Evans and Royal College of Surgeons rats.

1992 • 30 citations

Protein Kinase C Activation by Serotonin Potentiates Agonist-Induced Stimulation of cAMP Production in Cultured Rat Retinal Pigment Epithelial Cells

1997 • 30 citations

Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured human retinal pigment epithelium cells

1991 • 30 citations

The pigmented epithelium sustains cell growth and tissue differentiation of chicken retinal explants in vitro

1988 • 29 citations

Distribution of cholinergic amacrine cells in the retinas of normally pigmented and hypopigmented strains of rat and cat

1988 • 29 citations

Intraretinal Transplantation to Prevent Photoreceptor Degeneration

1997 • 29 citations

Morphogenesis and renewal of cone outer segments

1997 • 28 citations

Phagocytosis by the monkey pigment epithelium

1976 • 28 citations

Retinal cell transplants

1995 • 28 citations

Cyclic AMP Resets the Circadian Clock in Cultured Xenopus Retinal Photoreceptor Layers

1998 • 28 citations

Proteins from human retinal pigment epithelial cells: evidence that a major protein is actin.

1983 • 28 citations

A primary role for RPE transplants in the inhibition and regression of neovascularization in the RCS rat.

1994 • 27 citations

Immunocytochemical study on photoreceptor cell differentiation in the cultured retina of the chick

1984 • 26 citations

Characterization and Localization of Adenosine A₂ Receptors in Bovine Rod Outer Segments

1994 • 26 citations

Pigmented Epithelium Sustains Cell Proliferation and Decreases Expression of Opsins and Acetylcholinesterase in Reaggregated Chicken Retinospheroids

1997 • 26 citations

Studies on the mechanisms of signalling and inhibition by pertussis toxin on fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells

1991 • 25 citations

Kinetics of rod outer segment phagocytosis by cultured retinal pigment epithelial cells. Relationship to cell morphology.

1996 • 25 citations

Interactions of dopamine and the release of [³H]‐taurine and [³H]‐glycine from the isolated retina of the rat

1983 • 25 citations

Inductive effects of the retinal pigmented epithelium (RPE) on histogenesis of the avian retina as revealed by retinospheroid technology

1998 • 25 citations

Cone outer segment shedding in the goldfish retina characterized with the 3H-fucose technique.

1982 • 25 citations

Morphogenesis of photoreceptor outer segments in retinal development

1995 • 25 citations

Insulin Stimulation of Retinal Outer Segment Uptake by Cultured Human Retinal Pigment Epithelial Cells Determined by a Flow Cytometric Method

1994 • 25 citations

Retinal detachment prevents normal assembly of disk membranes in vitro.

1990 • 25 citations

Retinal Degeneration and Regeneration

1995 • 25 citations

The major myristoylated PKC substrate (MARCKS) is involved in cell spreading, tyrosine phosphorylation of paxillin, and focal contact formation

1997 • 25 citations

Topographical variation in growth in cultured bovine retinal pigment epithelium.

1988 • 25 citations

Spontaneously Arising Immortal Cell Line of Rat Retinal Pigmented Epithelial Cells

1993 • 25 citations

Daily patterns of the retinal pigment epithelium. Microperoxisomes and phagosomes

1981 • 24 citations

CD36 Expression in Sltered in Retinal Pigment Epithelial Cells of the RCS Rat

1997 • 24 citations

How good is the evidence to suggest that phagocytosis of ROS by RPE is receptor mediated?

1994 • 24 citations

Serotonergic projections to the retina of rat and goldfish

1998 • 23 citations

Further Studies on the Identification of the Phagocytosis Receptor of Rat Retinal Pigment Epithelial Cells

1996 • 23 citations

Mannose 6-phosphate receptors on the plasma membrane on rat retinal pigment epithelial cells.

1988 • 23 citations

The presence of dopamine-β-hydroxylase-like enzyme in the vertebrate retina

1985 • 23 citations

Normally Occurring Loss of Single Cells and Repair of Resulting Defects in Retinal Pigment Epithelium In Situ

1996 • 23 citations

Light‐evoked and kainic‐acid‐induced disc shedding by rod photoreceptors: Differential sensitivity to extracellular calcium

1986 • 23 citations

Melatonin and the phagocytic process of heterophils from the ring dove (Streptopelia risoria).

1997 • 23 citations

Atypical effect of dopamine in modulating the functional inhibition of NMDA receptors of cultured retina cells

1998 • 22 citations

Effects of extracellular matrix and Bruch's membrane on retinal outer segment phagocytosis by cultured human retinal pigment epithelium

1996 • 22 citations

Reduced phagosomal content of the retinal pigment epithelium in response to retinoid deprivation.

1992 • 22 citations

Chapter 2 The use of tissue culture techniques to study normal and diseased retinal pigment epithelium

1983 • 22 citations

Excitatory amino acids and rod photoreceptor disc shedding: Analysis using specific agonists

1988 • 21 citations

IP3 generation increases rod outer segment phagocytosis by cultured Royal College of Surgeons retinal pigment epithelium.

1995 • 21 citations

Extracellular matrix alterations precede vascularization of the retinal pigment epithelium in dystrophic rats.

1989 • 21 citations

Glutamate and taurine uptake by retinal pigment epithelium during rat development

1993 • 21 citations

The phagocytosis of ROS by RPE cells is inhibited by an antiserum to rat RPE cell plasma membranes

1992 • 20 citations

Phagocytic challenge induces changes in phosphorylation of retinal pigment epithelium proteins

1991 • 20 citations

Excitatory amino acid receptors in membranes from cultured human retinal pigment epithelium

1994 • 20 citations

Neurotransmitter-related features of the retinal pigment epithelium

1983 • 19 citations

Is rhodopsin the ligand for receptor-mediated phagocytosis of rod outer segments by retinal pigment epithelium?

1988 • 19 citations

Chronic clorgyline dampens rat retinal rhythms

1984 • 19 citations

The role of dopamine in the regulation of melatonin biosynthesis in vertebrate retina

1994 • 19 citations

Specific interaction of glutamate with membranes from cultured retinal pigment epithelium

1993 • 19 citations

Retinal pigment epithelial cells from dystrophic rats form normal tight junctions in vitro.

1997 • 18 citations

Chapter 7 Cholinergic mechanisms in the vertebrate retina

1983 • 18 citations

Muscarinic receptors binding in retinal pigment epithelium during rat development

1994 • 18 citations

Surface modification of retinal pigment epithelial cells: Effects on phagocytosis and glycoprotein composition

1987 • 18 citations

Tissue culture of rat pigment epithelium on different supporting media

1981 • 18 citations

Characterization and application of an in vitro detection system for studying the binding and phagocytosis of rod outer segments by retinal pigment epithelial cells

1992 • 17 citations

Reconstitution of the photoreceptor-pigment epithelium interface: l-glutamate stimulation of adhesive interactions and rod disc shedding after recombination of dissociated Xenopus laevis eyecups

1992 • 17 citations

Human retinal pigment epithelial cells possess V₁vasopressin receptors

1991 • 17 citations

Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways.

1995 • 17 citations

Retinopathy of prematurity: the influence of gestational age and retinal maturity on the statistical behavior of risk factors

1986 • 16 citations

The cytoskeleton of retinal pigment epithelial cells

1988 • 16 citations

A decreased Ca2+-wave propagation is found among cultured RPE cells from dystrophic RCS rats.

1998 • 16 citations

Pharmacologic evidence for 5-HT1A receptors associated with human retinal pigment epithelial cells in culture.

1997 • 16 citations

The use of sugar-coated beads to study phagocytosis in normal and dystrophic retina

1983 • 15 citations

Natural, high-mannose glycoproteins inhibit ROS binding and ingestion by RPE cell cultures

1995 • 15 citations

Phagocytosis of light- and dark-adapted rod outer segments by cultured RPE cells: a reassessment

1986 • 15 citations

In situ reactivity of the retinal pigment epithelium. I. Phagocytosis in the normal rat

1975 • 15 citations

Cell surface receptors associated with the retinal pigment epithelium: the adenylate cyclase and phospholipase C signal transduction pathways

1996 • 15 citations

Agonist-induced effects on cyclic AMP metabolism are affected in pigment epithelial cells of the royal college of surgeons rat

1995 • 15 citations

Differential effects of protease digestion on photoreceptor lectin binding sites.

1985 • 14 citations

Late-infantile ceroid-lipofuscinosis: lysine methylation of mitochondrial ATP synthase subunit c from lysosomal storage bodies

1997 • 14 citations

Transdifferentiation of chicken retinal pigmented epithelial cells in serum-free culture

1992 • 14 citations

Glycoproteins in the retinal pigment epithelium of normal and dystrophic rats.

1991 • 14 citations

Chapter 11 Neuroregulatory functions of adenosine in the retina

1991 • 14 citations

Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium

1996 • 14 citations

Are sugars involved in the binding of rhodopsin-membranes by the retinal pigment epithelium?

1987 • 13 citations

Effect of glycoconjugates on rod outer segment phagocytosis by retinal pigment epithelial explants in vitro assessed by a specific double radioimmunoassay procedure

1990 • 13 citations

Cytokine effects on phagocytosis of rod outer segments by retinal pigment epithelial cells of normal and dystrophic rats

1996 • 13 citations

Chapter 6 Retinal transplants

1990 • 13 citations

Intermediate filaments and other cytoskeletal structures in retinal pigment epithelial cells

1994 • 12 citations

Analysis of basic fibroblast growth factor in rats with inherited retinal degeneration

1996 • 12 citations

Retinal degeneration and transplantation in the Royal College of Surgeons rat

1998 • 11 citations

Human retinal pigment epithelial cells possess β2-adrenergic receptors

1992 • 11 citations

Photoreceptor survival and development in culture

1995 • 10 citations

A microsystem to assay lysosomal enzyme activities in cultured retinal pigment epithelial cells

1988 • 10 citations

RPE cells from normal rats do not secrete a factor which enhances the phagocytosis of ROS by dystrophic rat RPE cells

1991 • 10 citations

Chapter 4 Ontogeny of retinal pigment epithelium - photoreceptor complex and development of rhythmic metabolism under ambient light conditions

1990 • 10 citations

Effect of phytanic acid on cultured retinal pigment epithelium: An in vitro model for Refsum's disease

1992 • 10 citations

The effect of inhibitors of glycoprotein synthesis and processing on the phagocytosis of rod outer segments by cultured retinal pigment epithelial cells

1990 • 10 citations

Novel Characteristics of a Myosin Isolated from Mammalian Retinal Pigment Epithelial and Endothelial Cells

1997 • 10 citations

Peptides stimulate phosphoinositide hydrolysis in human retinal pigment epithelium.

1993 • 10 citations

Cyclic nucleotide phosphodiesterases in cultured normal and RCS rat pigment epithelium: Kinetics of cyclic AMP and cyclic GMP hydrolysis

1987 • 9 citations

Increased levels of leukotriene C₄in retinal pigment epithelium are correlated with early events in photoreceptor shedding inXenopus laevis

1989 • 9 citations

Phagocytosis of photoreceptor outer segments during retinal development in utero

1978 • 9 citations

Protein phosphorylation in cultured rat RPE. Effects of protein kinase C activation.

1988 • 8 citations

Endocytosis in the Rat Retinal Pigment Epithelium

1989 • 8 citations

Growth of pure cultures of retinal pigment epithelial cells using chorioretinal biopsies from the pig

1988 • 8 citations

Adenylyl Cyclase Type 7 Is the Predominant Isoform in the Bovine Retinal Pigment Epithelium

1998 • 8 citations

Expression of Protein Kinase C isoenzymes in cultured hooded rat retinal pigmented epithelial cells: comparison with dystrophic Royal College of Surgeons rat

1998 • 8 citations

Short-term organ culture of the retinal pigment epithelium in microtitration plates: Ultrastructural studies

1986 • 8 citations

Chapter 5 Biochemical ageing in the retina and RPE

1993 • 7 citations

Modification of the daily photoreceptor membrane shedding response in vitro by antioxidants.

1992 • 6 citations

The effects of retina-derived factors on the electrical and ultrastructural properties of the bovine pigment epithelium

1990 • 6 citations

Differential membrane protein phosphorylation in bovine retinal rod outer segment disk membranes as a function of disk age

1996 • 6 citations

Des mutations de gènes contrôlant le métabolisme des rétinoïdes 11-cis responsables de dystrophies rétiniennes sévères.

1998 • 6 citations

Disk shedding in the absence of a pigment epithelium in the lizard parietal eye

1993 • 5 citations

Evidence of a functional VIP receptor in cultured human retinal pigment epithelium

1995 • 5 citations

The phagocytic activity of the pigment epithelium in development and after optic nerve sectioning in the rat

1985 • 4 citations

Culture of retinal pigment epithelium from chorio‐retinal biopsies

1985 • 4 citations

Changes in the DNA breakage and crystallin synthesis of embryonic chicken lenses cultured in a tryptophan-deficient medium

1984 • 4 citations

Thermal control of rod outer segment length and shedding in a fish, Fundulus zebrinus

1995 • 4 citations

Normal and dystrophic rat retinal pigment epithelia display different sensitivities to plant lectins.

1991 • 3 citations

Retinal pigment epithelium of new-born rats is capable of phagocytosis of rod outer segments in vitro

1989 • 3 citations

Tubocurarine chloride inhibits rod outer segment shedding in the frog retina.

1987 • 2 citations

Phagocytic activity in the ischemic retinal pigment epithelial cells

1978 • 2 citations

Deleted Work

1955 • 0 citations