Transforming growth factor-β regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Pigment Epithelium Proliferation in Retinal Detachment (Massive Periretinal Proliferation)

1975 • 498 citations

Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye.

1989 • 481 citations

Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.

1991 • 470 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

[8] Preparation of retinal rod outer segments

1982 • 279 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Retinal detachment in the cat: the pigment epithelial-photoreceptor interface.

1983 • 219 citations

Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye.

1993 • 188 citations

Heterogeneity in localization of isoforms of TGF-beta in human retina, vitreous, and choroid.

1993 • 180 citations

Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells.

1993 • 157 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis.

1991 • 113 citations

Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C

1992 • 94 citations

Kinetic studies of rod outer segment binding and ingestion by cultured rat RPE cells

1987 • 87 citations

Calcium transients during Fc receptor-mediated and nonspecific phagocytosis by murine peritoneal macrophages.

1991 • 84 citations

A mannose receptor is involved in retinal phagocytosis.

1991 • 83 citations

Mechanism of collagen phagocytosis by human gingival fibroblasts: importance of collagen structure in cell recognition and internalization

1991 • 83 citations

Transforming growth factor beta and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts.

1988 • 76 citations

Evidence against the role of rhodopsin in rod outer segment binding to RPE cells.

1988 • 74 citations

Experimental posterior penetrating eye injury in the rabbit. II. Histology of wound, vitreous, and retina.

1979 • 73 citations

ROS ingestion by RPE cells is turned off by increased protein kinase C activity and by increased calcium

1991 • 70 citations

Isolation and characterization of a mannose receptor from human pigment epithelium.

1991 • 69 citations

Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and postreceptor signaling.

1992 • 61 citations

Phagocytosis by human retinal glial cells in culture.

1990 • 59 citations

Effects of combinations of transforming growth factor-beta 1 and tumor necrosis factor on induction of differentiation of human myelogenous leukemic cell lines.

1990 • 58 citations

RPE-mediated collagen gel contraction. Inhibition by colchicine and stimulation by TGF-beta.

1990 • 55 citations

Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion.

1990 • 51 citations

Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.

1989 • 50 citations

Staurosporine inhibits neutrophil phagocytosis but not iC3b binding mediated by CR3 (CD11b/CD18).

1991 • 47 citations

Defective neutrophil function in the autoimmune mouse strain MRL/lpr. Potential role of transforming growth factor-beta.

1991 • 46 citations

Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain

1988 • 43 citations

Signaling through CD19, Fc receptors or transforming growth factor‐β: each inhibits the activation of resting human B cells differently

1990 • 40 citations

Phagocytosis ofGiardia lambliatrophozoites by cytokine-activated macrophages

1992 • 34 citations

Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

1988 • 32 citations

New technique for in vitro culture of human retinal pigment epithelium.

1980 • 30 citations

Growth inhibitory activities in avascular tissues are recognized by anti-transforming growth factor β antibodies

1991 • 21 citations

Effects of gamma-interferon on human trabecular meshwork cell phagocytosis.

1993 • 18 citations

[Transforming growth factor beta in the vitreous of patients with epiretinal proliferation].

1990 • 17 citations

Phagocytosis of latex beads is defective in cultured human retinal pigment epithelial cells with persistent rubella virus infection.

1993 • 14 citations

Inhibitory Action of Transforming Growth Factor‐β on Induction of Differentiation of Myeloid Leukemia Cells

1989 • 14 citations

The effect of inhibitors of glycoprotein synthesis and processing on the phagocytosis of rod outer segments by cultured retinal pigment epithelial cells

1990 • 10 citations

Mononukleäre Phagozyten und ihre Wachstumsfaktoren: Schrittmacher der proliferativen Vitreoretinopathie?

1990 • 9 citations

Effects of type-β1 transforming growth factor on the proliferation and differentiation of mouse myelomonocytic leukemia cells (M1)

1991 • 8 citations

The effect of swainsonine on the phagocytosis of rod outer segments by rat RPE

1990 • 8 citations