The p53 tumor-suppressor gene in human breast cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Untitled

1982 • 1,310 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Atypical hyperplastic lesions of the female breast. A long-term follow-up study

1985 • 963 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

P53 expression in breast cancer

1988 • 612 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

1991 • 512 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland

1992 • 350 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Mitotic recombination of chromosome 17 in astrocytomas.

1989 • 288 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables.

1992 • 244 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.

1989 • 237 citations

Mutations in p53 as potential molecular markers for human breast cancer.

1991 • 222 citations

Anatomic markers of human premalignancy and risk of breast cancer

1990 • 219 citations

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.

1991 • 200 citations

Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder

1991 • 181 citations

The SV40 a gene product is required for the production of a 54,000 MW cellular tumor antigen

1979 • 179 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

1991 • 174 citations

The p53 tumor suppressor protein, a modulator of cell proliferation.

1992 • 171 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

p53 mutations occur in aggressive breast cancer.

1992 • 159 citations

Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments]

1989 • 157 citations

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico‐pathological parameters

1992 • 152 citations

Relation between p53 overexpression and established prognostic factors in breast cancer.

1991 • 149 citations

Expression of p53 protein in infiltrating and in‐situ breast carcinomas

1991 • 145 citations

Prognostic significance of p53 gene alterations in node-negative breast cancer

1993 • 115 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

Pattern of p53 Gene Mutations in Breast Cancers of Women of the Midwestern United States

1992 • 94 citations

Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.

1991 • 92 citations

REPORTS

1991 • 92 citations

Expression of ras Rb1 and p53 proteins in human breast cancer.

1992 • 32 citations

Cellular and molecular advances in elucidating p53 function

1992 • 21 citations

Transforming activity of mutant human p53 alleles

1991 • 19 citations