The reaction of sulfhydryl groups of sodium and potassium ion-activated adenosine triphosphatase with N-ethylmaleimide. The relationship between ligand-dependent alterations of nucleophilicity and enzymatic conformational states.

Purification and characterization of (Na+ + K+)-ATPase III. Purification from the outer medulla of mammalian kidney after selective removal of membrane components by sodium dodecylsulphate

1974 • 936 citations

Activation by Adenosine Triphosphate in the Phosphorylation Kinetics of Sodium and Potassium Ion Transport Adenosine Triphosphatase

1972 • 826 citations

Further investigations on a Mg++ + Na+-activated adenosintriphosphatase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane

1960 • 799 citations

A Phosphorylated Intermediate in Adenosine Triphosphate-dependent Sodium and Potassium Transport across Kidney Membranes

1965 • 487 citations

Flexibility of an Active Center in Sodium-Plus-Potassium Adenosine Triphosphatase

1969 • 476 citations

Stoichiometry and Localization of Adenosine Triphosphate-dependent Sodium and Potassium Transport in the Erythrocyte

1964 • 355 citations

Binding of Adenosine Triphosphate to Sodium and Potassium Ion-stimulated Adenosine Triphosphatase

1971 • 349 citations

The Stability of N-Ethylmaleimide and its Reaction with Sulfhydryl Groups

1955 • 340 citations

Purification and characterization of (Na+, K+)-ATPase. V. Conformational changes in the enzyme. Transitions between the Na-form and the K-form studied with tryptic digestion as a tool

1975 • 328 citations

Purification of the Sodium- and Potassium-dependent Adenosine Triphosphatase from Canine Renal Medulla

1971 • 319 citations

Mechanism of cardiac glycoside inhibition of the (Na+-K+)-dependent ATPase from cardiac tissue

1968 • 288 citations

Some Reactions of N-Ethylmaleimide¹

1960 • 277 citations

Properties of the Two Polypeptides of Sodium- and Potassium-dependent Adenosine Triphosphatase

1972 • 267 citations

Binding of ATP to brain microsomal ATPase Determination of the ATP-binding capacity and the dissociation constant of the enzyme-ATP complex as a function of K+ concentration

1971 • 263 citations

Studies on the Characterization of the Sodium-Potassium Transport Adenosine Triphosphatase

1971 • 231 citations

Tryptophan fluorescence of (Na+ + K+)-ATPase as a tool for study of the enzyme mechanism

1978 • 231 citations

Conformational transitions between Na+-bound and K+-bound forms of (Na+ + K+)-ATPase, studied with formycin nucleotides

1978 • 222 citations

Similarity of the Active Site of Phosphorylation of the Adenosine Triphosphatase for Transport of Sodium and Potassium Ions in Kidney to That for Transport of Calcium Ions in the Sarcoplasmic Reticulum of Muscle

1973 • 206 citations

Isolation and characterization of the components of the sodium pump

1974 • 205 citations

Characterization of 2',3'-O-(2,4,6-trinitrocyclohexadienylidine)adenosine 5'-triphosphate as a fluorescent probe of the ATP site of sodium and potassium transport adenosine triphosphatase. Determination of nucleotide binding stoichiometry and ion-induced changes in affinity for ATP.

1981 • 187 citations

Sodium-Potassium-activated Adenosine Triphosphatase of Electrophorus Electric Organ

1968 • 182 citations

THE ROLE OF SODIUM IONS IN THE ACTIVATION OF ELECTROPHORUS ELECTRIC ORGAN ADENOSINE TRIPHOSPHATASE

1963 • 180 citations

A Cycle for Ouabain Inhibition of Sodium- and Potassium-dependent Adenosine Triphosphatase

1969 • 179 citations

Photoaffinity Labeling of the Ouabain-Binding Site on (Na ⁺ + K ⁺ ) Adenosinetriphosphatase

1974 • 160 citations

Inhibition of (Na⁺ and K⁺)-dependent adenosine triphosphatase and its partial reactions by quercetin

1976 • 159 citations

The effect of sulphydryl-blocking reagents and of urea on the (Na+ + K+)-activated enzyme system

1965 • 149 citations

Synthesis of adenosine triphosphate and exchange between inorganic phosphate and adenosine triphosphate in sodium and potassium ion transport adenosine triphosphatase.

1975 • 149 citations

Structural studies of sodium and potassium ion-activated adenosine triphosphatase. The relationship between molecular structure and the mechanism of active transport.

1975 • 149 citations

Formation and Decomposition of a Phosphorylated Intermediate in the Reaction of Na+-K+ Dependent ATPase*

1970 • 148 citations

Sodium-Potassium-activated Adenosine Triphosphatase of Electrophorus Electric Organ

1966 • 146 citations

Proteolytic fragmentation of the catalytic subunit of the sodium and potassium adenosine triphosphatase. Alignment of tryptic and chymotryptic fragments and location of sites labeled with ATP and iodoacetate

1979 • 129 citations

Stoichiometry and molecular weight of the minimum asymmetric unit of canine renal sodium and potassium ion-activated adenosine triphosphatase.

1980 • 125 citations

Occlusion of K ions in the unphosphorylated sodium pump

1979 • 119 citations

Phosphorylation from adenosine triphosphate of sodium- and potassium-activated adenosine triphosphatase. Comparison of enzyme-ligand complexes as precursors to the phosphoenzyme.

1977 • 117 citations

Sodium-Potassium-activated Adenosine Triphosphatase

1969 • 114 citations

A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models.

1980 • 109 citations

The Reactions of Sodium and Potassium Ion-activated Adenosine Triphosphatase with Specific Antibodies

1974 • 106 citations

Disposition of the band 3 polypeptide in the human erythrocyte membrane. The reactive sulfhydryl groups.

1979 • 96 citations

Effect of ATP on the intermediary steps of the reaction of the (Na++K+)-dependent enzyme system. I. Studied by the use of N-ethylmaleimide inhibition as a tool

1974 • 88 citations

Purification and characterization of (Na+ + K+-ATPase. II. Preparation by zonal centrifugation of highly active (Na+ + K+-ATPase from the outer medulla of rabbit kidneys

1971 • 86 citations

Defective conformational response in a selectively trypsinized (Na+ + K+)-ATPase studied with tryptophan fluorescence

1980 • 85 citations

Ouabain receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants

1973 • 85 citations

Sodium ions, acting at high‐affinity extracellular sites, inhibit sodium‐ATPase activity of the sodium pump by slowing dephosphorylation.

1979 • 82 citations

Sulfhydryl Groups of Sodium-Potassium Transport Adenosine Triphosphatase

1973 • 80 citations

Evidences for a Sulfhydryl Group in the ATP-Binding Site of (Na+ + K+)-Activated ATPase

1975 • 78 citations

Studies on (Na+ +K+ activated ATPase, XLI. Effects of N-ethylmaleimide on overall and partial reactions

1977 • 75 citations

Elementary steps of the (Na+ + K+)-ATPase mechanism, studied with formycin nucleotides

1978 • 73 citations

The Titration of the Cardiac Glycoside Binding Site of the (Na+ + K+)-Adenosine Triphosphatase

1972 • 66 citations

(Sodium-potassium ion)-activated ATPase: ligand-induced conformational transitions and alterations in subunit interactions evidenced by cross-linking studies

1980 • 66 citations

Studies on ()-activated ATPase. XLII. Evidence for two classes of essential sulfhydryl groups

1978 • 64 citations

Reaction of purified (Na,K)-ATPase with the fluorescent sulfhydryl probe 2-(4'-maleimidylanilino)naphthalene 6-sulfonic acid. Characterization and the effects of ligands.

1979 • 51 citations

Thermodynamics of the Rate of Binding of Ouabain to the Sodium, Potassium-Adenosine Triphosphatase

1974 • 49 citations

Inhibition of sodium- and potassium-dependent adenosine triphosphatase by N-ethylmaleimide. I. Effects on sodium-sensitive phosphorylation and potassium-sensitive dephosphorylation.

1972 • 44 citations

Effect of temperature on phosphorylation and ouabain binding to N-ethylmaleimide-treated (Na+, K+)-ATPase.

1978 • 34 citations

Fluorescence studies of the sodium and potassium transport adenosine triphosphatase labeled with fluorescein mercuric acetate and anthroylouabain.

1980 • 34 citations

SODIUM STIMULATED [¹⁴C]ADENOSINE DIPHOSPHATE‐ADENOSINE TRIPHOSPHATE EXCHANGE ACTIVITY IN BRAIN MICROSOMES

1968 • 32 citations

Conformational changes of purified (Na+ + K+)-ATPase detected by a sulfhydryl fluorescence probe

1977 • 29 citations

Lack of Gross Protein Structure Changes in the Working Cycle of (Na⁺, K⁺)‐Dependent Adenosinetriphosphatase

1980 • 26 citations

Primary structures of cysteine-containing peptides from the calcium ion-transporting adenosine triphosphatase of rabbit sarcoplasmic reticulum

1978 • 24 citations

Ouabain-binding and phosphorylation of (Na++K+)ATPase treated with N-ethylmaleimide or oligomycin

1976 • 23 citations

Ouabain binding to (Na+ + K+)-ATPase effects of nucleotide analogues and ethacrynic acid

1974 • 22 citations

Conformational changes of membrane-bound (Na+−K+)-ATPase as revealed by trypsin digestion

1979 • 21 citations

The effect of ATP upon the reactivity of SH groups in sarcoplasmic reticulum membranes

1976 • 21 citations

Interaction of a new fluorescent reagent with sulfhydryl groups of the (Na++K+)-stimulated ATPase

1976 • 17 citations

Evidence for subclasses of SH groups in (Na+ + K+)-ATPase

1976 • 13 citations

Small Differences in Tryptophan Fluorescence Spectra of ‘Sodium’ and ‘Potassium’ Forms of (Na⁺, K⁺)‐Dependent Adenosinetriphosphatase

1980 • 13 citations

Na⁺,K⁺,‐ATPase: ligand‐induced alterations in subunit crosslinking

1979 • 10 citations

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