Molecular Mechanisms of Antibiotic Action

Structural considerations in the interaction of DNA and acridines

1961 • 2,199 citations

Structure of a Ribonucleic Acid

1965 • 1,370 citations

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

1965 • 943 citations

The bacterial chromosome and its manner of replication as seen by autoradiography

1963 • 756 citations

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

1963 • 564 citations

STREPTOMYCIN, SUPPRESSION, AND THE CODE

1964 • 481 citations

PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS

1964 • 474 citations

THE ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, III. THE INHIBITION OF THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVIN

1962 • 449 citations

Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

1960 • 378 citations

BASIS OF ACTINOMYCIN ACTION, I. DNA BINDING AND INHIBITION OF RNA-POLYMERASE SYNTHETIC REACTIONS BY ACTINOMYCIN

1962 • 371 citations

Genetic Code: The ‘Nonsense’ Triplets for Chain Termination and their Suppression

1965 • 369 citations

The puromycin reaction and its relation to protein synthesis

1964 • 364 citations

The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus

1953 • 341 citations

Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.

1965 • 340 citations

Mechanism of Action of Nalidixic Acid on Escherichia coli II. Inhibition of Deoxyribonucleic Acid Synthesis

1965 • 322 citations

The mode of action of actinomycin D

1960 • 308 citations

THE CHROMOSOMAL SITE SPECIFYING A RIBOSOMAL PROTEIN IN ESCHERICHIA COLI

1964 • 265 citations

URIDINE-5'-PYROPHOSPHATE DERIVATIVES

1952 • 245 citations

Lysostaphin: Enzymatic mode of action

1965 • 234 citations

X-Ray Diffraction and Molecular Model Building Studies of The Interaction of Actinomycin with Nucleic Acids

1963 • 194 citations

PROTEIN SYNTHESIS IN ERYTHROID CELLS, I. RETICULOCYTE RIBOSOMES ACTIVE IN STIMULATING AMINO ACID INCORPORATION

1962 • 186 citations

STUDIES ON THE RIBOSOMES OF STREPTOMYCIN-SENSITIVE AND RESISTANT STRAINS OF ESCHERICHIA COLI

1964 • 182 citations

COMPETITIVE INHIBITION OF ENZYMATIC REACTIONS BY OXAMYCIN

1960 • 174 citations

The Enzymatic Synthesis of D-Alanyl-D-alanine. III. On the Inhibition of D-Alanyl-D-alanine Synthetase by the Antibiotic D-Cycloserine^*

1964 • 173 citations

Inhibition of aminoacyl-sRNA binding to ribosomes by tetracycline

1965 • 166 citations

Development of Lysozyme-Resistance in Micrococcus Lysodiekticus and its Association With an Increased O-Acetyl Content of the Cell Wall

1958 • 160 citations

MECHANISM OF PEPTIDE BOND FORMATION IN POLYPEPTIDE SYNTHESIS

1964 • 158 citations

Direction of Reading of the Genetic Message

1965 • 153 citations

ACCUMULATION OF LABILE PHOSPHATE IN STAPHYLOCOCCUS AUREUS GROWN IN THE PRESENCE OF PENICILLIN

1949 • 141 citations

Site of action of Polymyxin on Pseudomonas aeruginosa: Antagonism by Cations

1954 • 130 citations

The chemical composition of the protoplast membrane of Micrococcus lysodeikticus

1958 • 127 citations

Interaction of Actinomycin C with constituents of nucleic acids

1961 • 123 citations

Inhibition of polypeptide synthesis by streptomycin

1962 • 116 citations

Differences in Chloramphenicol Sensitivity of Cell-free Amino Acid Polymerization Systems

1964 • 109 citations

BIOSYNTHESIS OF CELL WALL MUCOPEPTIDE BY A PARTICULATE FRACTION FROM STAPHYLOCOCCUS AUREUS

1964 • 108 citations

LACK OF FIDELITY IN THE TRANSLATION OF SYNTHETIC POLYRIBONUCLEOTIDES

1964 • 104 citations

Mediation of Divalent Metal Ions in the Binding of Tetracycline to Macromolecules

1961 • 103 citations

Effect of Streptomycin on Escherichia Coli: Uptake of Streptomycin by Escherichia coli

1960 • 102 citations

Studies on the Mechanism of Action of Chloramphenicol

1963 • 97 citations

CHEMICAL STRUCTURE AND BIOSYNTHESIS OF BACTERIAL CELL WALLS

1963 • 96 citations

Metal Complexation of the Tetracycline Hydrochlorides

1963 • 91 citations

MECHANISMS OF ANTIBIOTIC ACTION.

1963 • 89 citations

Actinomycin D as a Probe for Nucleic Acid Secondary Structure

1964 • 87 citations

Enzymatic Synthesis of the Peptide in Bacterial Uridine Nucleotides

1962 • 87 citations

Reconstitution of Oxidative Phosphorylation in Preparations from Micrococcus lysodeikticus

1962 • 85 citations

INHIBITION OF PROTEIN SYNTHESIS BY CHLORTETRACYCLINE IN THE E. COLI IN VITRO SYSTEM

1965 • 83 citations

INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELL-FREE SYSTEMS BY CHLORAMPHENICOL

1964 • 81 citations

STREPTOMYCIN RESISTANCE IN ESCHERICHIA COLI ANALYZED BY TRANSDUCTION

1960 • 77 citations

A study of the ribonucleic acid of normal and chloromycetin-inhibited bacteria by zone electrophoresis

1957 • 75 citations

Teichoic acid from the walls of Staphylococcus aureus H. 2. Location of phosphate and alanine residues

1962 • 73 citations

Biochemical Studies on the Metabolism of Griseofulvin

1960 • 70 citations

Antibacterial Activity of Lincomycin and Pristinamycin: A Comparison with Erythromycin

1964 • 63 citations

The action of amphotericin B on Mycoplasma laidlawii

1965 • 58 citations

Actinomycin and Its Effects

1964 • 50 citations

Aspects of the Stability of a Bacterial Ribonucleic Acid

1958 • 49 citations

Preparation and properties of the mucopeptides of cell walls of gram-negative bacteria

1962 • 47 citations

Chloramphenicol Inhibition of Polyuridylic Acid Binding to E. coli Ribosomes

1964 • 47 citations

Biosynthesis of ribosomes: Fate of chloramphenicol particles and of pulse-labeled RNA in Escherichia coli

1965 • 44 citations

Antimicrobial Chemotherapeutic Agents: The Nature of Their Action and Selective Toxicity

1963 • 44 citations

The effect of polyene antibiotics on permeability in Neurosporacrassa

1961 • 44 citations

A Structural Similarity between N-Acetylmuramic Acid and Penicillin as a Basis for Antibiotic Action

1962 • 42 citations

EFFECT OF CHLORAMPHENICOL ON PROTEIN SYNTHESIS.

1964 • 40 citations

The assimilation of amino-acids by bacteria. 12. The action of inhibitors and antibiotics on the accumulation of free glutamic acid and the formation of combined glutamate in Staphylococcus aureus

1951 • 37 citations

Inhibition of the biosynthesis of cell-wall mucopeptides by the penicillins. A study of penicillin-sensitive and penicillin-resistant strains of Staphylococcus aureus

1961 • 35 citations

Magnesium Binding as an Explanation of the Mode of Action of Novobiocin

1962 • 34 citations

Studies on the mode of action of psicofuranine

1960 • 32 citations

Inhibition of nucleic acid synthesis by novobiocin

1965 • 30 citations

Structure and function in microorganisms.

1959 • 27 citations

MEMBRANE STEROLS AND THE SELECTIVE TOXICITY OF POLYENE ANTIFUNGAL ANTIBIOTICS.

1963 • 27 citations

Amelioration by Ingestion of Phenylalanine of Toxic Effects of Chloramphenicol on Bone Marrow

1965 • 27 citations

ACTION OF STREPTOMYCIN AND RELATED ANTIBIOTICS.

1964 • 27 citations

Inhibition of cell-wall-mucopeptide formation in Escherichia coli by benzylpenicillin and 6-[<scp>d</scp>(−)-α-aminophenylacetamido]penicillanic acid (ampicillin)

1962 • 26 citations

Inhibition of Synthesis of the Cell Wall of Staphylococcus aureus by Cephalothin

1964 • 25 citations

Cytochromes of Bacillus megaterium and Bacillus subtilis

1960 • 24 citations

Acid-Soluble Nucleotides of Staphylococcus Aureus: Massive Accumulation of a Derivative of Cytidine Diphosphate in the Presence of Penicillin

1961 • 23 citations

Induction of Cephalosporinase and Penicillinase in Proteus Species

1964 • 22 citations

SUBUNITS FOR CONTROL AND CATALYSIS IN ASPARTATE TRANSCARBAMYLASE.

1964 • 20 citations

EFFECT OF ERYTHROMYCIN ON PROTEIN BIOSYNTHESIS IN BACILLUS SUBTILIS.

1963 • 14 citations

HIGH ENERGY EXCHANGE REACTION OF TRITIUM ATOMS WITH CYCLOPROPANE

1959 • 10 citations

ISOLATION, CHARACTERIZATION, AND DISTRIBUTION OF CEPHALOSPORINASE.

1963 • 9 citations

MULTIPLE EFFECTS OF PENICILLIN.

1963 • 4 citations

A Technique for Urine Collection in the Female Rat for Investigating Iodine Metabolism

1964 • 3 citations