Actinomycin and Its Effects

Allosteric proteins and cellular control systems

1963 • 2,187 citations

An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis

1961 • 1,108 citations

THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES

1960 • 852 citations

Prolonged Survival of Human-Kidney Homografts by Immunosuppressive Drug Therapy

1963 • 544 citations

The action of thyroid hormones at the cell level

1963 • 526 citations

Hormone-sensitive Lipase and Monoglyceride Lipase Activities in Adipose Tissue

1964 • 487 citations

POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA

1963 • 472 citations

THE ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, III. THE INHIBITION OF THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVIN

1962 • 449 citations

Induktion von puff-veränderungen in den speicheldrüsenchromosomen von Chironomus t̆entans durch Ecdyson

1960 • 434 citations

Immune Response and Mitosis of Human Peripheral Blood Lymphocytes in vitro

1963 • 389 citations

BASIS OF ACTINOMYCIN ACTION, I. DNA BINDING AND INHIBITION OF RNA-POLYMERASE SYNTHETIC REACTIONS BY ACTINOMYCIN

1962 • 371 citations

Selective effects of actinomycin D on the intracellular distribution of RNA synthesis in tissue culture cells

1963 • 356 citations

Protein Synthesis and Adrenocorticotropin Responsiveness

1963 • 345 citations

New Concepts on the Mode of Action of Hormones

1963 • 314 citations

The mode of action of actinomycin D

1960 • 308 citations

Actinomycin D Inhibition of Deoxyribonucleic Acid-Dependent Synthesis of Ribonucleic Acid

1962 • 304 citations

Macromolecule synthesis and the influence of actinomycin on early development

1964 • 298 citations

Relation of Cortisone and Synthesis of Ribonucleic Acid to Induced and Developmental Enzyme Formation

1963 • 280 citations

HORMONAL CONTROL OF ENZYME SYNTHESIS IN BARLEY ENDOSPERM

1964 • 260 citations

Insulin-dependent Synthesis of Liver Glucokinase in the Rat

1963 • 257 citations

MESSENGER RNA TURNOVER AND PROTEIN SYNTHESIS IN B. SUBTILIS INHIBITED BY ACTINOMYCIN D

1962 • 255 citations

ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE

1964 • 254 citations

A STUDY OF THE EFFECTS OF DRUGS IN PROLONGING SURVIVAL OF HOMOLOGOUS RENAL TRANSPLANTS IN DOGS*

1962 • 229 citations

Patterns of Macromolecular Synthesis in Normal and Virus-infected Mammalian Cells

1962 • 208 citations

BIOCHEMISTRY OF ACTINOMYCINS.

1963 • 180 citations

The effects of actinomycin D on growth of Rous sarcoma virus in vitro

1963 • 177 citations

EVIDENCE FOR A REQUIREMENT FOR PROTEIN SYNTHESIS FOR AUXIN-INDUCED CELL ENLARGEMENT

1963 • 171 citations

GLUCOCORTICOID STIMULATION OF THE BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE

1963 • 169 citations

Breakdown of Rat-Liver Ergosomes in vivo after Actinomycin Inhibition of Messenger RNA Synthesis

1963 • 161 citations

Participation of Deoxyribonucleic Acid in the Multiplication of Influenza Virus

1962 • 156 citations

Activation of ribosomes in sea urchin eggs in response to fertilization

1961 • 156 citations

THE ROLE OF PROTEIN SYNTHESIS IN EARLY ESTROGEN ACTION

1961 • 151 citations

THE ROLE OF RNA SYNTHESIS IN EARLY ESTROGEN ACTION

1963 • 148 citations

THE RELATIONSHIP BETWEEN RNA SYNTHESIS AND LOOP STRUCTURE IN LAMPBRUSH CHROMOSOMES

1963 • 145 citations

The inhibition of ribonucleic acid synthesis in mammalian cells by actinomycin D

1963 • 141 citations

The Independence of Hydrocortisone and Tryptophan Inductions of Tryptophan Pyrrolase

1959 • 138 citations

Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells

1964 • 136 citations

Cytodifferentiation and Its Controls

1964 • 132 citations

INDUCED ENZYME FORMED ON BACTERIAL POLYRIBOSOMES

1964 • 130 citations

AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLES

1962 • 126 citations

Interaction of Actinomycin C with constituents of nucleic acids

1961 • 123 citations

AN EARLY EFFECT OF ESTROGEN ON PROTEIN SYNTHESIS

1963 • 122 citations

Effects of Actinomycin D on Morphogenesis

1963 • 121 citations

THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS

1964 • 118 citations

The action of gonadotropic hormones upon rabbit testis in vitro

1962 • 117 citations

The effects of antimicrobial agents on deoxyribonucleic acid polymerase

1963 • 116 citations

Mechanism of the antinatriuretic action of aldosterone

1963 • 112 citations

Zur Wirkungsweise von Actinomycinen

1960 • 111 citations

The differential effect of actinomycin D on the biosynthesis of enzymes in Bacillus subtilis and Bacillus cereus

1963 • 110 citations

On the inhibition of RNA synthesis by actinomycin

1962 • 104 citations

Evidence for the nonparticipation of DNA in viral RNA synthesis

1961 • 103 citations

Effects of insulin on amino acid and ribonucleic acid metabolism in rat adipose tissue

1962 • 102 citations

Electron microscope studies on HeLa cell lines sensitive and resistant to actinomycin D.

1961 • 98 citations

Role of Enzymes in Homeostasis

1964 • 96 citations

Actinomycin D and Vaccinia Virus Infection of Hela Cells

1963 • 94 citations

Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents.

1958 • 94 citations

RNA metabolism of B. subtilis

1963 • 92 citations

Actinomycin D and the Response to Parathyroid Hormone

1964 • 92 citations

Effects of Hormone Administration on Lactic Dehydrogenase

1964 • 90 citations

Puromycin and adrenal responsiveness to adrenocorticotropic hormone

1962 • 85 citations

THE TOXICITY OF ACTINOMYCIN D*

1960 • 83 citations

Action of Insulin on the Isolated Rat Diaphragm in the Presence of Actinomycin D and Puromycin

1963 • 82 citations

BIOSYNTHESIS OF THYROGLOBULIN: RELATIONSHIP TO RNA-TEMPLATE AND PRECURSOR PROTEIN

1963 • 81 citations

Effect of actinomycin D on the synthesis of DNA polymerase in hepatectomized rats

1963 • 81 citations

Actinomycin D in the treatment of methotrexate-resistant trophoblastic disease in women.

1962 • 80 citations

THE INHIBITION OF A BIOLOGICAL CLOCK BY ACTINOMYCIN D

1962 • 80 citations

OLD AND NEW RNA IN THE EMBRYOGENESIS OF THE PURPLE SEA URCHIN

1963 • 80 citations

SEQUENCES OF RNA AND PROTEIN SYNTHESIS DURING EARLY ESTROGEN ACTION

1964 • 76 citations

Cytochemical observations on the nucleolus-ribosome system

1963 • 76 citations

Actinomycin: Inhibition of Cortisone-Induced Synthesis of Hepatic Gluconeogenic Enzymes

1963 • 73 citations

Corticosteroids and Enzyme Activity

1964 • 71 citations

A Difference between the Modes of Action of Substrate and Hormonal Inducers of Rat Liver Tryptophan Pyrrolase

1961 • 70 citations

The Decay and Protection of Messenger RNA in Bacteria

1963 • 67 citations

The Activation of Luteal Phosphorylase by Luteinizing Hormone

1964 • 67 citations

Observations on the interrelations between adrenal protein, RNA and DNA during prolonged ACTH administration

1963 • 66 citations

The stimulatory effect of 3-methylcholanthrene on microsomal amino acid incorporation and benzpyrene hydroxylase activity and its inhibition by actinomycin D

1963 • 64 citations

Inhibition of protein synthesis in E. coli protoplasts by actinomycin-D

1963 • 63 citations

ISOTOPIC STUDIES ON ESTROGEN-INDUCED ACCELERATIONS OF RIBONUCLEIC ACID AND PROTEIN SYNTHESIS

1963 • 62 citations

ESTROGEN-INDUCED FORMATION OF UTERINE RIBOSOMES

1964 • 56 citations

Actinomycin D: Its Effect on Antibody Formation in vitro

1963 • 55 citations

Effect of growth hormone on ribonucleic acid metabolism. 1. Incorporation of radioactive phosphate into ribonucleic acid fractions of rat liver

1962 • 55 citations

Stimulation of messenger RNA synthesis in rat liver by cortisol

1964 • 52 citations

Effect of Actinomycin D on Interferon Production by ‘Active’ and ‘Inactive’ Chikungunya Virus in Chick Cells

1963 • 50 citations

Inhibitors of mitochondrial protein synthesis

1963 • 50 citations

Effects of alterations in hormonal status on ribosomes of rat uterus

1964 • 50 citations

PREVENTION OF HORMONE ACTION BY LOCAL APPLICATION OF ACTINOMYCIN D

1963 • 49 citations

Actinomycin D Effects in Frog Embryos: Evidence for Sequential Synthesis of DNA-Dependent RNA

1963 • 48 citations

Breakdown of Nuclear Ribonucleic Acid in the Presence of Actinomycin D

1964 • 47 citations

Actinomycin inhibition of in vitro protein synthesis in rat liver

1963 • 47 citations

GENE EXPRESSION IN DIFFERENTIATED CELLS

1963 • 47 citations

Regulation of Nucleic Acids of Muscles and Accessory Sex Organs of Guinea Pigs by Androgens1

1964 • 47 citations

Effect of Actinomycin D on HeLa Cell Nuclear RNA Metabolism

1963 • 44 citations

Growth hormone control of messenger RNA synthesis

1963 • 43 citations

Actinomycin D-resistant RNA synthesis in animal cells

1963 • 42 citations

AN INFLUENCE OF INSULIN ON THE SYNTHESIS OF A RAPIDLY LABELED RNA BY ISOLATED RAT DIAPHRAGM

1963 • 42 citations

Effects of glucocorticois administration on the incorporation of labelled amino acids into protein by cell-free rat-liver systems

1962 • 42 citations

THE EFFECT OF ACTINOMYCIN D ON A SPECTRUM OF TUMORS*

1960 • 41 citations

Mechanisms of Synthesis and Control of Protein and Ribonucleic Acid Synthesis in the Cell Nucleus

1963 • 40 citations

Dopamine: Its Occurrence in Molluscan Ganglia

1963 • 39 citations

Acquisition of actinomycin D insensitivity during differentiation of pancreas exocrine cells

1964 • 38 citations

BASIS OF ACTINOMYCIN ACTION, II. EFFECT OF ACTINOMYCIN ON THE NUCLEOSIDE TRIPHOSPHATE-INORGANIC PYROPHOSPHATE EXCHANGE

1963 • 35 citations

INDUCTION OF MAMMARY SECRETION IN PREGNANT RATS AND RABBITS BY HYDROCORTISONE ACETATE¹

1961 • 33 citations

The nutritional regulation of ribonucleic-acid metabolism in the liver cell

1960 • 32 citations

Further Studies on Effects of Thyroid-stimulating Hormone on Thyroid Glucose Oxidation

1963 • 31 citations

Genaktivitäten in den Riesenchromosomen von Chironomus tentans und ihre Beziehungen zur Entwicklung—III

1962 • 31 citations

Studies related to the mode of action of actinomycin D

1962 • 30 citations

Blood Corticosterone-levels in the Rat after Administration of Amino-acids

1963 • 30 citations

Parathyroid Hormone and Anion Uptake in Isolated Mitochondria

1964 • 29 citations

Intracellular Site of Newcastle Disease Virus Nucleic Acid Synthesis.

1963 • 29 citations

THE ROLE OF RNA IN REPRESSION OF ENZYME SYNTHESIS

1963 • 29 citations

Some aspects of the relationship of RNA metabolism to development in normal and mutant mouse embryos cultivated in vitro

1963 • 29 citations

EXPERIMENTAL EVALUATION OF ACTINOMYCIN D*

1960 • 29 citations

Actinomycin D: Specific Inhibitory Effects on the Explanted Chick Embryo

1963 • 27 citations

Inhibition of Multiplication of Bacteriophage by Actinomycin

1961 • 26 citations

Some observations on the stimulation in vitro of corticoid production by adenosine 3′,5′-monophosphate in rat adrenals

1962 • 26 citations

Actinomycin, puromycin and ethionine inhibition of synthesis of gluconeogenic enzymes in acute diabetes

1964 • 25 citations

The Actinomycetes and Their Antibiotics

1963 • 25 citations

Shortening by Actinomycin D of Latent Period of Multiplication of Sendai Virus

1963 • 25 citations

Modification of the Radiation Effect on Hair Roots of the Mouse by Actinomycin

1962 • 24 citations

Further Studies on the Stimulation of Adrenal Protein Synthesis by ACTH: An Effect on Microsomes and Ribosomes

1964 • 23 citations

Inhibition of Protein Synthesis in Rat Adrenals by Adrenocorticotrophin and Cyclic 3′,5′-Adenosine Monophosphate

1964 • 23 citations

Effect of Actinomycin D on Tissue Cultures of Normal and Neoplastic Cells<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1958 • 23 citations

ENZYMES IN TISSUES RESPONSIVE TO CORTICOSTEROIDS.

1963 • 23 citations

Isolation and Chemical Characterization of a -CRF from Pig Posterior Pituitary Glands.

1963 • 22 citations

Actinomycin D and radiation therapy.

1962 • 22 citations

Teratogenic action of actinomycin D in the embryonic chick

1961 • 22 citations

Effet de l'actinomycine sur la différenciation nerveuse de l'ectoblaste chez les embryons d'amphibien

1963 • 22 citations

Alteration of Mutation Frequency by Treatment with Actinomycin D

1961 • 21 citations

Insulin and incorporation of radioactivity into nucleic acid fraction of isolated diaphragm

1960 • 21 citations

Insulin Stimulation of Glycogen Synthesis in the Isolated Rat Diaphragm in the Absence and in the Presence of Puromycin and Actinomycin D

1964 • 19 citations

Incorporation of Amino Acids Into Rat Adrenal Proteinin Vivo: Effects of Adrenocorticotrophin and Growth Hormone1

1964 • 18 citations

The mechanism of chemical mutagenesis. II. Interactions of selected compounds with manganous chloride

1958 • 17 citations

�ber die cytostatische Wirkung verschiedener neuer biosynthetischer Actinomycine bei experimentellen Tumoren

1957 • 17 citations

A Description of Various Classes of RNA from HeLa Cells

1963 • 17 citations

Effect of Thyrotropin on Nucleic Acids and Protein Contents of the Thyroid

1963 • 16 citations

Teratogenic action of actinomycin D in the embryonic chick II. Early development

1961 • 15 citations

RADIATION RECOVERY ENHANCED THROUGH INHIBITORS OF PROTEIN SYNTHESIS AND AMINO ACIDS

1963 • 14 citations

Stimulation of thyroidal radioiodine uptake by actinomycin and fluorouracil

1964 • 13 citations

[Cytostatic action of various new biosynthetic actinomycins in experimental tumors].

1957 • 12 citations

Effects of insulin and of dl-aldosterone on protein synthesis by mouse uteri in organ culture

1963 • 12 citations

Die Wirkung von Actinomycinen auf menschliche Gewebe in vitro

1960 • 11 citations

The Protein-Anabolic Effect of Testosterone Propionate in the Hypothyroid Rat

1955 • 11 citations

Effect of growth hormone on ribonucleic acid metabolism. 2. Effect of growth-hormone administration on the activities of 5′-nucleotidase, adenase, guanase and xanthine oxidase

1962 • 10 citations

STUDIES ON THE CHEMICAL NATURE OF CROSSING OVER IN DROSOPHILA MELANOGASTER I. PRELIMINARY RESULTS ON THE EFFECTS OF ACTINOMYCIN D

1963 • 10 citations

Side-Effects of Combined Radiation and Chemotherapy in the Treatment of Malignant Tumors

1963 • 10 citations

STEROID BIOSYNTHESIS IN VITRO BY A VIRILIZING SUPRARENAL TUMOUR

1963 • 9 citations

EXPERIMENTAL LUNG TRANSPLANTATION

1964 • 9 citations

Influence of Actinomycins on the Content of 17-Hydroxycorticosteroids in Guinea Pig Plasma

1962 • 9 citations

Effect of Actinomycin M upon Mitosis

1957 • 8 citations

The Use of Dangerous Drugs During Pregnancy: Congenital Abnormalities

1964 • 7 citations

Stimulation of amino acid transport in isolated rat ovaries by follicle stimulating hormone in the absence of protein synthesis

1964 • 6 citations

Effect of Thyrotropin on in vivo Iodine Binding in Thyroid Subcellular Fractions

1963 • 6 citations

SOME BIOCHEMICAL AND CLINICAL ASPECTS OF THE ACTION OF ANDROGENS AND ESTROGENS.

1963 • 6 citations

Hormones and Macromolecules

1964 • 5 citations

Macromolecular synthesis in reovirus-infected L cells☆

1963 • 3 citations

Effects of growth hormone on the chick embryo

1963 • 3 citations

Prophase-like chromosome condensation induced by actinomycin D in the slime mold,Physarum polycephalum

1964 • 2 citations

Thyrotropin and the Rat Hemidiaphragm

1964 • 2 citations