Overlapping octamer and TAATGARAT motifs in the VF65-response elements in herpes simplex virus immediate-early promoters represent independent binding sites for cellular nuclear factor III

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter

1985 • 763 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis

1980 • 429 citations

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes

1983 • 423 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

1987 • 386 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

Purification of nuclear factor I by DNA recognition site affinity chromatography.

1986 • 331 citations

Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes

1982 • 315 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro

1985 • 289 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4

1985 • 273 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer.

1987 • 263 citations

Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication

1986 • 256 citations

Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

1985 • 242 citations

Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1.

1987 • 234 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

Transcription Factor OTF-1 Is Functionally Identical to the DNA Replication Factor NF-III

1988 • 194 citations

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1

1986 • 192 citations

OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences.

1988 • 184 citations

Sequence-specific interactions between cellular DNA-binding proteins and the adenovirus origin of DNA replication.

1987 • 169 citations

Stimulation of Expression of a Herpes Simplex Virus DNA-Binding Protein by Two Viral Functions

1985 • 165 citations

Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes.

1987 • 163 citations

Distinct factors bind to apparently homolgous sequences in the immunoglobulin heavy-chain enhancer

1986 • 161 citations

Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.

1986 • 157 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein

1988 • 149 citations

Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator.

1982 • 148 citations

Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes.

1984 • 140 citations

A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation

1985 • 128 citations

The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1

1987 • 121 citations

Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene

1984 • 113 citations

DNA Sequence Anaylysis of an Immediate-Early Gene Region of the Herpes Simplex Virus Type 1 Genome (Map Coordinates 0.950 to 0.978)

1982 • 113 citations

Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes.

1980 • 112 citations

Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection

1984 • 99 citations

Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors

1987 • 94 citations

Purification and characterization of nuclear factor III (origin recognition protein C), a sequence-specific DNA binding protein required for efficient initiation of adenovirus DNA replication.

1988 • 93 citations

Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors

1987 • 92 citations

Adenovirus origin of DNA replication: sequence requirements for replication in vitro.

1987 • 87 citations

Analysis of DNA sequences which regulate the transcription of herpes simplex virus immediate early gene 3: DNA sequences required for enhancer-like activity and response to trans-activation by a virion polypeptide

1986 • 82 citations

Replication origins and a sequence involved in coordinate induction of the immedlate-early gene family are conserved in an intergenic region of herpes simplex virus

1984 • 78 citations

Transcriptional regulation of a herpes simplex virus immediate early gene is mediated through an enhancer-type sequence.

1984 • 76 citations

Multiple Sequence Elements Are Required for Maximal in Vitro Transcription of a Human Histone H2B Gene

1986 • 73 citations

Sequence-Specific Interactions Between Cellular DNA-Binding Proteins and the Adenovirus origin of DNA Replication

1987 • 73 citations

Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2

1989 • 71 citations

Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans

1985 • 68 citations

Immediate-early mRNA-2 of herpes simplex viruses types 1 and 2 is unsplced: conserved sequences around the 5′ and 3′ termini correspond to transcription regulatory signals

1983 • 68 citations

Differentiation and DNA contact points of host proteins binding at the cis site for virion-mediated induction of alpha genes of herpes simplex virus 1

1988 • 66 citations

Interaction between the octamer-binding protein nuclear factor III and the adenovirus origin of DNA replication

1988 • 51 citations

Protein-nucleotide contacts in the immunoglobulin heavy-chain promoter region.

1987 • 42 citations

Adenovirus Origin of DNA Replication: Sequence Requirements for Replication In Vitro

1987 • 33 citations

Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide

1980 • 29 citations

Differential activation of hybrid genes containing herpes simplex virus immediate-early or delayed-early promoters after superinfection of stable DNA-transfected cell lines

1985 • 27 citations

In vitro transcription of immunoglobulin genes in a B-cell extract: effects of enhancer and promoter sequences.

1987 • 27 citations

In Vitro Transcription of Immunoglobulin Genes in a B-Cell Extract: Effects of Enhancer and Promoter Sequences

1987 • 15 citations