Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses

Dendritic cells and the control of immunity

1998 • 14,345 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

2001 • 883 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 • 693 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets

2002 • 461 citations

Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection

2001 • 354 citations

Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells

2001 • 306 citations

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN‐α induction in plasmacytoid dendritic cells

2003 • 298 citations

Modulation of TH1 and TH2 Cytokine Production with the Immune Response Modifiers, R-848 and Imiquimod

1999 • 259 citations

Divergent Therapeutic and Immunologic Effects of Oligodeoxynucleotides with Distinct CpG Motifs

2001 • 252 citations

Interferon-producing cells: on the front line in immune responses against pathogens

2002 • 242 citations

Beyond six colors: A new era in flow cytometry

2003 • 202 citations

CpG Oligodeoxynucleotides as Vaccine Adjuvants in Primates

2002 • 199 citations

Depletion in blood CD11c-positive dendritic cells from HIV-infected patients

1999 • 181 citations

Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells

2003 • 170 citations

Adjuvant Activities of Immune Response Modifier R-848: Comparison with CpG ODN

2000 • 157 citations

Putative Immunodominant Human Immunodeficiency Virus-Specific CD8⁺T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

2000 • 156 citations

CpG-Containing Oligonucleotides Are Efficient Adjuvants for Induction of Protective Antiviral Immune Responses with T-Cell Peptide Vaccines

1999 • 132 citations

T-cell subsets and cytokines in parasitic infections

1992 • 131 citations

Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus

2002 • 118 citations

The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

1980 • 112 citations

Antigen Presentation by Dendritic Cells Focuses T Cell Responses Against Immunodominant Peptides: Studies in the Hen Egg-White Lysozyme (HEL) Model1

1998 • 74 citations

Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells.

1998 • 66 citations

Adjuvant Effects of Imiquimod on a Herpes Simplex Virus Type 2 Glycoprotein Vaccine in Guinea Pigs

1993 • 60 citations

Immunostimulatory CpG Motifs Trigger a T Helper-1 Immune Response to Human Immunodeficiency Virus Type-1 (HIV-1) gp160 Envelope Proteins

1999 • 58 citations

Differential Presentation of the Same MHC Class I Epitopes by Fibroblasts and Dendritic Cells

1998 • 56 citations