Brain-derived Neurotrophic Factor Expression in VivoIs under the Control of Neuron-restrictive Silencer Element

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Synaptic Activity and the Construction of Cortical Circuits

1996 • 3,004 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

The Neuron-Restrictive Silencer Factor (NRSF): A Coordinate Repressor of Multiple Neuron-Specific Genes

1995 • 1,078 citations

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

1995 • 1,078 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Functional Interactions of Neurotrophins and Neurotrophin Receptors

1995 • 825 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells

1992 • 420 citations

Identification of potential target genes for the neuron-restrictive silencer factor.

1996 • 411 citations

Neuronal Expression of Zinc Finger Transcription Factor REST/NRSF/XBR Gene

1998 • 370 citations

Silencing the type II sodium channel gene: A model for neural-specific gene regulation

1992 • 315 citations

Neurotrophins and activity-dependent development of the neocortex

1996 • 305 citations

Neurotrophic factors and synaptic plasticity

1995 • 259 citations

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

1993 • 248 citations

Fast actions of neurotrophic factors

1996 • 177 citations

Silencing is golden: negative regulation in the control of neuronal gene transcription

1995 • 159 citations

Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes

1997 • 146 citations

Neuron-specific Gene Expression of Synapsin I

1996 • 141 citations

Comparative localization of fibroblast growth factor receptor-1, -2, and -3 mRNAs in the rat brain: In situ hybridization analysis

1997 • 137 citations

The neuron-restrictive silencer element: A dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain

1997 • 134 citations

The action of neurotrophins in the development and plasticity of the visual cortex

1996 • 121 citations

Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice.

1995 • 121 citations

Tissue-specific Expression of the L1 Cell Adhesion Molecule Is Modulated by the Neural Restrictive Silencer Element

1997 • 117 citations

The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates

1996 • 105 citations

Cell Type-specific Regulation of Choline Acetyltransferase Gene Expression

1996 • 99 citations

Distinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene

1994 • 82 citations

Silencer Elements Modulate the Expression of the Gene for the Neuron-Glia Cell Adhesion Molecule, Ng-CAM

1995 • 78 citations

The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development

1998 • 73 citations

Alternate 5′ exons in the rat brain-derived neurotrophic factor gene: differential patterns of expression across brain regions

1994 • 67 citations

Single-stranded DNA-binding Proteins and Neuron-restrictive Silencer Factor Participate in Cell-specific Transcriptional Control of the NMDAR1 Gene

1998 • 57 citations

Two Promoters Direct Transcription of the Mouse NT‐3 Gene

1994 • 54 citations

Early induction of mRNA for calbindin-D28k and BDNF but not NT-3 in rat hippocampus after kainic acid treatment

1997 • 54 citations

Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes.

1992 • 52 citations

The presence of both negative and positive elements in the 5′-flanking sequence of the rat Na, K-ATPase α3 subunit gene are required for brain expression in transgenic mice

1994 • 48 citations

Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons

1996 • 48 citations

A zinc finger protein that represses transcription of the human MHC class II gene, DPA.

1996 • 45 citations

Helix-Loop-Helix Transcription Factors Mediate Activation and Repression of the p75LNGFR Gene

1995 • 44 citations

Organization, sequence and functional analysis of a mouse BDNF promoter

1997 • 40 citations

Attenuation of the seizure‐induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin‐dependent protein kinases

1998 • 27 citations

Identification of a negative regulatory element in the 5′-flanking region of the human dopamine β-hydroxylase gene

1995 • 26 citations

A Negative Regulatory Element in the Rat Dopamine β‐Hydroxylase Gene Contributes to the Cell Type Specificity of Expression

1995 • 19 citations

Structural and Functional Characterization of the Rat Neurotrophin-4 Gene

1997 • 18 citations

Localization of putative calcium-responsive regions in the rat BDNF gene

1997 • 17 citations