Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features

2000 • 923 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

1997 • 703 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

1997 • 516 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Role of the Nucleophosmin (NPM) Portion of the Non-Hodgkin’s Lymphoma-Associated NPM-Anaplastic Lymphoma Kinase Fusion Protein in Oncogenesis

1997 • 371 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

2000 • 362 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

2000 • 317 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

2000 • 310 citations

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).

1996 • 297 citations

Protein tyrosine kinases and cancer

1997 • 285 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

Nucleophosmin-Anaplastic Lymphoma Kinase of Large-Cell Anaplastic Lymphoma Is a Constitutively Active Tyrosine Kinase That Utilizes Phospholipase C-γ To Mediate Its Mitogenicity

1998 • 281 citations

Retrovirus-Mediated Gene Transfer of NPM-ALK Causes Lymphoid Malignancy in Mice

1997 • 278 citations

Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.

2001 • 262 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Physical and Functional Interactions between Pim-1 Kinase and Cdc25A Phosphatase

1999 • 239 citations

STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells

2000 • 235 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene

1998 • 198 citations

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5

2000 • 196 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

1999 • 191 citations

Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas

2000 • 188 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

1996 • 153 citations

Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related.

1992 • 110 citations

Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation

1999 • 110 citations

bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity.

1996 • 109 citations

Oncostatin M: Signal transduction and biological activity

1999 • 92 citations

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

1998 • 90 citations

Carboxyl-Truncated STAT5β Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors

1998 • 87 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 77 citations

Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line

2000 • 65 citations

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.

1992 • 63 citations