Energetics of the calcium-transporting ATPase.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Linked Functions and Reciprocal Effects in Hemoglobin: A Second Look

1964 • 1,613 citations

The Sodium Pump

1975 • 969 citations

Cytosolic phosphorylation potential.

1979 • 906 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Purification and Properties of an Adenosine Triphosphatase from Sarcoplasmic Reticulum

1970 • 835 citations

Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

1979 • 718 citations

Fundamentals of Clinical Chemistry

1977 • 592 citations

Energetics of Ligand Binding to Proteins

1975 • 519 citations

Kinetics and mechanism

1953 • 475 citations

Cooperative calcium binding and ATPase activation in sarcoplasmic reticulum vesicles.

1980 • 384 citations

Free Energy Transduction in Biology

1977 • 342 citations

The Phosphorylation of the Membranal Protein of the Sarcoplasmic Vesicles during Active Calcium Transport

2005 • 263 citations

ATP synthesis by the reverse of the sarcoplasmic calcium pump

1971 • 261 citations

Enzyme kinetics and substrate stabilization of detergent-solubilized and membraneous (Ca2+ + Mg2+)-activated ATPase from sarcoplasmic reticulum. Effect of protein-protein interactions.

1980 • 241 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle: V. Vectorial Requirements for Calcium and Magnesium Ions of Three Partial Reactions of ATPase: Formation and Decomposition of a Phosphorylated Intermediate and ATP-Formation from ADP and the Intermediate*

1971 • 237 citations

ATP and Ca2+ binding by the Ca2+ pump protein of sarcoplasmic reticulum

1973 • 225 citations

Transient state kinetic studies of sarcoplasmic reticulum adenosine triphosphatase.

1975 • 212 citations

Calcium-Activated Tension of Skinned Muscle Fibers of the Frog

1974 • 208 citations

Occurrence and Characteristics of a Rapid Exchange of Phosphate Oxygens Catalyzed by Sarcoplasmic Reticulum Vesicles

1973 • 206 citations

Phosphorylase and the Control of Glycogen Degradation* *The authors wish to thank the National Institutes of Arthritis and Metabolic Disease, NIH, United States Public Health Service (AM 07902), the National Science Foundation (GN 5932X), and the Muscular Dystrophy Association of America for support during preparation of this review.

1971 • 201 citations

Effect of Diethyl Ether on the Adenosine Triphosphatase Activity and the Calcium Uptake of Fragmented Sarcoplasmic Reticulum of Rabbit Skeletal Muscle

1967 • 192 citations

Occlusion of Divalent Cations in the Phosphorylated Calcium Pump of Sarcoplasmic Reticulum

1980 • 191 citations

Indications for an oligomeric structure and for conformational changes in sarcoplasmic reticulum Ca2+-ATPase labelled selectively with fluorescein

1980 • 190 citations

Interaction of calcium and magnesium in activating and inhibiting the nucleoside triphosphatase of sarcoplasmic reticulum vesicles

1975 • 189 citations

The Utilization of Binding Energy in Coupled Vectorial Processes

1980 • 166 citations

Transport and inhibitory Ca2+ binding sites on the ATPase enzyme isolated from the sarcoplasmic reticulum.

1975 • 156 citations

Transient kinetics of Ca2+ transport of sarcoplasmic reticulum. A comparison of cardiac and skeletal muscle.

1978 • 155 citations

The Equilibrium Constants of the Adenosine Triphosphate Hydrolysis and the Adenosine Triphosphate-Citrate Lyase Reactions

1973 • 153 citations

The Effect of Delipidation on the Adenosine Triphosphatase of Sarcoplasmic Reticulum. Electron Microscopy and Physical Properties

1974 • 152 citations

Mechanism and Catalysis of Reactions of Acyl Phosphates. II. Hydrolysis¹

1961 • 151 citations

Kinetics and Regulation of Sarcoplasmic Reticulum ATPase

1977 • 150 citations

Formation of adenosine triphosphate from Pi and adenosine diphosphate by purified Ca-2+-adenosine triphosphatase.

1975 • 150 citations

Synthesis of adenosine triphosphate and exchange between inorganic phosphate and adenosine triphosphate in sodium and potassium ion transport adenosine triphosphatase.

1975 • 149 citations

Regulation of the conformation transition in the Ca-ATPase from sarcoplasmic reticulum by pH, temperature, and calcium ions.

1982 • 146 citations

Transient kinetics of sarcoplasmic reticulum Ca2++Mg2+ ATPase studied by fluorescence

1978 • 144 citations

Partial reactions in the catalytic and transport cycle of sarcoplasmic reticulum ATPase

1978 • 140 citations

Modification of the ATP binding site of the Ca²⁺‐ATPase from sarcoplasmic reticulum by fluorescein isothiocyanate

1981 • 140 citations

Isolation and characterization of tryptic fragments of the adenosine triphosphatase of sarcoplasmic reticulum.

1976 • 136 citations

Role of the Ca²⁺ion concentration gradient in the adenosine 5'-triphosphate-inorganic phosphate exchange catalyzed by sarcoplasmic reticulum

1974 • 136 citations

Reaction mechanism of calcium-ATPase of sarcoplasmic reticulum. Substrates for phosphorylation reaction and back reaction, and further resolution of phosphorylated intermediates.

1980 • 129 citations

Modulation of calcium binding in sarcoplasmic reticulum adenosinetriphosphatase

1981 • 125 citations

The functional unit of sarcoplasmic reticulum Ca2+-ATPase. Active site titration and fluorescence measurements.

1982 • 125 citations

Substrate regulation of the sarcoplasmic reticulum ATPase. Transient kinetic studies.

1979 • 110 citations

A new mechanism by which an H⁺concentration gradient drives the synthesis of adenosine triphosphate, pH jump, and adenosine triphosphate synthesis by the Ca²⁺ dependent adenosine triphosphatase of sarcoplasmic reticulum

1977 • 110 citations

Equilibria and Rates for Acetyl Transfer among Substituted Phenyl Acetates, Acetylimidazole, O-Acylhydroxamic Acids, and Thiol Esters

1964 • 104 citations

The sarcoplasmic reticulum-glycogenolytic complex in mammalian fast twitch skeletal muscle. Proposed in vitro counterpart of the contraction-activated glycogenolytic pool.

1980 • 103 citations

Adenosine 5'-triphosphate modulation of catalytic intermediates of calcium-adenosine triphosphatase of sarcoplasmic reticulum subsequent to enzyme phosphorylation

1983 • 101 citations

Binding of divalent cation to phosphoenzyme of sodium- and potassium-transport adenosine triphosphatase.

1978 • 93 citations

Calcium Gradient‐Dependent and Calcium Gradient‐Independent Phosphorylation of Sarcoplasmic Reticulum by Orthophosphate

1978 • 92 citations

A direct fluorescence study of the transient steps induced by calcium binding to sarcoplasmic reticulum ATPase.

1980 • 91 citations

Can free energy transduction be localized at some crucial part of the enzymatic cycle?

1981 • 88 citations

Stopped flow and rapid quenching measurement of the transient steps induced by calcium binding to sarcoplasmic reticulum adenosine triphosphatase. Competition with Ca2+-independent phosphorylation.

1981 • 85 citations

Characterization of Cardiac Sarcoplasmic Reticulum ATP‐ADP Phosphate Exchange and Phosphorylation of the Calcium Transport Adenosine Triphosphatase

1976 • 83 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1974 • 82 citations

Dynamic reversal of enzyme carboxyl group phosphorylation as the basis of the oxygen exchange catalyzed by sarcoplasmic reticulum adenosine triphosphatase

1977 • 82 citations

Equilibrium state of ATP-driven ion pumps in relation to physiological ion concentration gradients.

1981 • 80 citations

Slow dissociation of ATP from the calcium ATPase.

1982 • 75 citations

Regulation of steady state level of phosphoenzyme and ATP synthesis in sarcoplasmic reticulum vesicles during reversal of the Ca2+ pump.

1976 • 72 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1972 • 71 citations

Sarcoplasmic reticulum ATPase phosphorylation from inorganic phosphate in the absence of a calcium gradient. Steady state and kinetic fluorescence studies.

1981 • 68 citations

Biphasic kinetics of ATP hydrolysis by calcium-dependent ATPase of the sarcoplasmic reticulum of skeletal muscle. Evidence for a nucleoside triphosphate effector site.

1979 • 67 citations

Phosphorylation from Inorganic Phosphate and ATP Synthesis of Sarcoplasmic Membranes

1977 • 66 citations

Kinetics of the inactivation of the ATPase of sarcoplasmic reticulum by dicyclohexylcarbodiimide.

1981 • 54 citations

Sequential reactions in Pi utilization for ATP synthesis by sarcoplasmic reticulum.

1979 • 52 citations

Side-specific effects of sodium on (Na,K)-ATPase. Studies with inside-out red cell membrane vesicles.

1979 • 52 citations

Rapid kinetic studies of active Ca2+ transport in sarcoplasmic reticulum

1980 • 50 citations

The binding of nucleotides and bivalent cations to the calcium-and-magnesium ion-dependent adenosine triphosphatase from rabbit muscle sarcoplasmic reticulum

1976 • 49 citations

Phosphorylation of (Ca2+)-adenosinetriphosphatase by inorganic phosphate: van't Hoff analysis of enthalpy changes

1981 • 49 citations

The Ca2+-ATPase partial reactions in cardiac and skeletal sarcoplasmic reticulum. A comparison of transient state kinetic data.

1980 • 48 citations

Models for the active transport of cations ⋯ The steady-state analysis

1977 • 44 citations

Effect of K+ on phosphorylation of the sarcoplasmic reticulum ATPase by either Pi or ATP.

1980 • 44 citations

Ionized and Bound Calcium Inside Isolated Sarcoplasmic Reticulum of Skeletal Muscle and Its Significance in Phosphorylation of Adenosine Triphosphatase by Orthophosphate

1979 • 43 citations

Comparison between ATP-Supported and GTP-Supported Phosphate Turnover of the Calcium-Transporting Sarcoplasmic Reticulum Membranes

1979 • 38 citations

Phosphoenzyme formation from ATP in the ATPase of sarcoplasmic reticulum. Effect of KCl or ATP and slow dissociation of ATP from precursor enzyme-ATP complex.

1982 • 35 citations

What is a Coupled Vectorial Process?

1983 • 33 citations

Factors Affecting the Transient Phase of the Ca2+, Mg2+-Dependent

1978 • 30 citations

Formation of Magnesium‐Phosphoenzyme and Magnesium‐Calcium‐Phosphoenzyme in the Phosphorylation of Adenosine Triphosphatase by Orthophosphate in Sarcoplasmic Reticulum

1981 • 28 citations

Transient state kinetic studies of phosphorylation by ATP and Pi of the calcium-dependent ATPase from sarcoplasmic reticulum

1979 • 28 citations

Mechanism of active transport: free energy dissipation and free energy transduction.

1982 • 21 citations

Steady state of an ATP-driven calcium pump: limitations on kinetic and thermodynamic parameters.

1982 • 21 citations

Design principles for active transport systems

1978 • 20 citations

Reversible loss of cooperative calcium ion binding by sarcoplasmic reticulum calcium adenosinetriphosphatase

1982 • 12 citations

CONTROL OF THE CONFORMATIONAL STATES OF THE CALCIUM TRANSPORT ENZYME OF SARCOPLASMIC RETICULUM BY CALCIUM

1978 • 5 citations