Mechanism of quinolone resistance in anaerobic bacteria

Quinolone resistance from a transferable plasmid

1998 • 1,116 citations

Emerging Mechanisms of Fluoroquinolone Resistance

2001 • 588 citations

Mechanism of plasmid-mediated quinolone resistance

2002 • 563 citations

Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction

1989 • 378 citations

Mechanisms of Action and Resistance of Older and Newer Fluoroquinolones

2000 • 376 citations

Efflux-Mediated Resistance to Fluoroquinolones in Gram-Negative Bacteria

2000 • 355 citations

Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria

2001 • 316 citations

Comparison of the antibacterial activities of the quinolones Bay 12- 8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin [published erratum appears in J Antimicrob Chemother 1998 Jun;41(6):672]

1997 • 307 citations

Multicenter Survey of the Changing In Vitro Antimicrobial Susceptibilities of Clinical Isolates of Bacteroides fragilis Group, Prevotella, Fusobacterium, Porphyromonas , and Peptostreptococcus Species

2001 • 223 citations

Restricting the Selection of Antibiotic‐Resistant Mutant Bacteria: Measurement and Potential Use of the Mutant Selection Window

2002 • 221 citations

Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756

2000 • 167 citations

Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe

2003 • 127 citations

A MATE Family Multidrug Efflux Transporter Pumps out Fluoroquinolones in Bacteroides thetaiotaomicron

2001 • 117 citations

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

2002 • 114 citations

Multicenter Study of In Vitro Susceptibility of the Bacteroides fragilis Group, 1995 to 1996, with Comparison of Resistance Trends from 1990 to 1996

1999 • 111 citations

National Survey on the Susceptibility ofBacteroides fragilisGroup: Report and Analysis of Trends for 1997–2000

2002 • 108 citations

Comparative Effects of Moxifloxacin and Clarithromycin on the Normal Intestinal Microflora

2000 • 101 citations

In Vitro Activities of Sitafloxacin (DU-6859a) and Six Other Fluoroquinolones against 8,796 Clinical Bacterial Isolates

2000 • 91 citations

Plasmid-determined tetracycline resistance involves new transport systems for tetracycline

1978 • 87 citations

Clinical Pharmacology of the Fluoroquinolones: Studies in Human Dynamic/Kinetic Models

2000 • 86 citations

Resistance to Moxifloxacin in Toxigenic Clostridium difficile Isolates Is Associated with Mutations in gyrA

2001 • 75 citations

Quinolone Activity Against Anaerobes

1999 • 72 citations

Quinolone resistance by mutations in chromosomal gyrase genes. Just the tip of the iceberg?

1998 • 68 citations

Comparative Activity of Moxifloxacin in Vitro Against Obligately Anaerobic Bacteria

2000 • 68 citations

Minimal inhibitory concentrations and time-kill determination of moxifloxacin against aerobic and anaerobic isolates

2002 • 66 citations

Membrane Permeability Modifications Are Involved in Antibiotic Resistance in Klebsiella pneumoniae

2000 • 64 citations

Possible Role for the New Fluoroquinolones (Levofloxacin, Grepafloxacin, Trovafloxacin, Clinafloxacin, Sparfloxacin, and DU-6859a) in the Treatment of Anaerobic Infections: Review of Current Information on Efficacy and Safety

1996 • 62 citations

Comparative in vitro activity of gemifloxacin

2000 • 60 citations

Active Efflux of Norfloxacin by Bacteroides fragilis

1998 • 59 citations

gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains

2001 • 49 citations

In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms

2002 • 45 citations

Quinolone accumulation in Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus

1992 • 43 citations

Ecological Disturbances in Intestinal Microflora Caused by Clinafloxacin, an Extended-Spectrum Quinolone

2000 • 33 citations

In vitro activity of new quinolones against Clostridium difficile

2001 • 30 citations

In Vitro Activities of the Des-Fluoro(6) Quinolone BMS-284756 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft Tissue Animal and Human Bite Wound Infections

2002 • 29 citations

Molecular Cloning of the gyrA and gyrB Genes of Bacteroides fragilis Encoding DNA Gyrase

1999 • 29 citations

Roles of gyrA Mutations in Resistance of Clinical Isolates and In Vitro Mutants of Bacteroides fragilis to the New Fluoroquinolone Trovafloxacin

2000 • 28 citations

Comparative In Vitro Activities of Gemifloxacin, Other Quinolones, and Nonquinolone Antimicrobials against Obligately Anaerobic Bacteria

2001 • 24 citations

Pharmacodynamics of Trovafloxacin and Levofloxacin against Bacteroides fragilis in an In Vitro Pharmacodynamic Model

2002 • 23 citations

Efflux-Mediated Fluoroquinolone Resistance in the Bacteroides fragilis Group

2002 • 23 citations

A Resistance-Nodulation-Cell Division Family Xenobiotic Efflux Pump in an Obligate Anaerobe, Porphyromonas gingivalis

2002 • 22 citations

Susceptibility of the Bacteroides fragilis group to newer quinolones and other standard anti-anaerobic agents

2001 • 21 citations

Fluoroquinolone Resistance in Anaerobic Bacteria following Exposure to Levofloxacin, Trovafloxacin, and Sparfloxacin in an In Vitro Pharmacodynamic Model

2001 • 20 citations

Elimination of plasmids by enoxacin and ofloxacin at near inhibitory concentrations

1986 • 20 citations

Activity of BMS284756 (T-3811) tested against anaerobic bacteria, Campylobacter jejuni, Helicobacter pylori and Legionella spp.

2001 • 20 citations

Accumulation of Norfloxacin by Bacteroides fragilis

2000 • 19 citations

Comparative In Vitro Activities of Clinafloxacin and Trovafloxacin against 1,000 Isolates of Bacteroides fragilis Group: Effect of the Medium on Test Results

2000 • 15 citations

Ecological impact of the des-F(6)-quinolone, BMS-284756, on the normal intestinal microflora

2002 • 14 citations

The effect of DU-6859a, a new potent fluoroquinolone, on fecal microflora in human volunteers.

1995 • 8 citations