Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis.

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members 1 1Edited by M. Yaniv

2000 • 682 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

1999 • 660 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity

2000 • 640 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

A model of angiogenesis in the mouse cornea.

1996 • 411 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin

1995 • 273 citations

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

1996 • 250 citations

A General Strategy for Isolation of Endothelial Cells From Murine Tissues

1997 • 232 citations

Preclinical and Clinical Studies of MMP Inhibitors in Cancer

1999 • 222 citations

VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels1

1998 • 216 citations

Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).

1996 • 187 citations

Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains

1999 • 170 citations