Spontaneous thrombosis in mice carrying the factor V Leiden mutation

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

Increased frequency of genetic thrombophilia in women with complications of pregnancy

1999 • 826 citations

Ethnic Distribution of Factor V Leiden in 4047 Men and Women

1997 • 625 citations

Prothrombin and Factor V Mutations in Women with a History of Thrombosis during Pregnancy and the Puerperium

2000 • 495 citations

The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation

1999 • 483 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1994 • 446 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis

1994 • 428 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

1988 • 405 citations

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

1996 • 395 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

1995 • 314 citations

Targeted disruption of the murine tissue factor gene results in embryonic lethality

1996 • 277 citations

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

1996 • 270 citations

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

1998 • 253 citations

Protein C inhibitor. Purification from human plasma and characterization.

1983 • 238 citations

Factor V Leiden (FV R506Q) in Families with Inherited Antithrombin Deficiency

1996 • 237 citations

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

1997 • 236 citations

Factor V Leiden Mutation as a Risk Factor for Recurrent Pregnancy Loss

1998 • 209 citations

Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood

1985 • 204 citations

Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice.

1998 • 181 citations

Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V

1994 • 125 citations

Taking stock of complex trait genetics in mice

1995 • 119 citations

Prospective Evaluation of Hemostatic System Activation and Thrombin Potential in Healthy Pregnant Women with and without Factor V Leiden

1999 • 114 citations

Mortality and Causes of Death in Families With the Factor V Leiden Mutation (Resistance to Activated Protein C)

1997 • 93 citations

Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugation

1989 • 71 citations

Prothrombin fragment 1+2 and thrombin–antithrombin complex levels in patients with inherited APC resistance due to factor V Leiden mutation

1996 • 65 citations

Abnormal formation of the prothrombinase complex:

1987 • 55 citations

Heightened Thrombin Generation in Individuals with Resistance to Activated Protein C

1996 • 48 citations

The Structure and Function of Murine Factor V and Its Inactivation by Protein C

1998 • 46 citations

Ethnic distribution of factor V Leiden in 4,047 men and women. Implications for venous thromboembolism screening.

1997 • 23 citations

Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation

1999 • 23 citations