Dendritic cells are defective in breast cancer patients: a potential role for polyamine in this immunodeficiency

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Consequences of Cell Death

2000 • 1,382 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

A Guide to the Polyamines

1998 • 677 citations

The use of dendritic cells in cancer immunotherapy

2003 • 641 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

Immature myeloid cells and cancer-associated immune suppression

2002 • 304 citations

Spermine Inhibits Proinflammatory Cytokine Synthesis in Human Mononuclear Cells: A Counterregulatory Mechanism that Restrains the Immune Response

1997 • 298 citations

Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

2004 • 254 citations

Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses

2004 • 239 citations

Large-scale generation of mature monocyte-derived dendritic cells for clinical application in cell factories™

2002 • 127 citations

Dendritic cells are dysfunctional in patients with operable breast cancer

2004 • 122 citations

Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin.

2002 • 96 citations

IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells.

2001 • 85 citations

Polyamine deprivation: a new tool in cancer treatment.

1994 • 68 citations

All‐trans retinoic acid skews monocyte differentiationinto interleukin‐12‐secreting dendritic‐like cells

2003 • 65 citations

The natural polyamines and the immune system

1994 • 62 citations

Bcl-2-Mediated Inhibition of Apoptosis Prevents Immunogenicity and Restores Tumorigenicity of Spontaneously Regressive Tumors

1998 • 51 citations

Polyamine profiles in tumor, normal tissue of the homologous breast, blood, and urine of breast cancer sufferers

2000 • 50 citations

Polyamine deprivation prevents the development of tumour-induced immune suppression

1997 • 36 citations

Polyamine deprivation stimulates natural killer cell activity in cancerous mice.

1993 • 29 citations

Red blood cell poly amines, anaemia and tumour growth in the rat

1996 • 12 citations

Cytotoxic effector cells with antitumor activity can be amplified ex vivo from biopsies or blood of patients with renal cell carcinoma for cell therapy use

2003 • 6 citations

Synergistic activation of macrophage activity by polyamine deprivation and cyclophosphamide.

1997 • 6 citations