Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

1981 • 1,655 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Studies on the Role of Adenosine 3',5'-Monophosphate in the Hepatic Actions of Glucagon and Catecholamines

1971 • 321 citations

Biochemical Studies on Liver Functions in Primary Cultured Hepatocytes of Adult Rats1

1978 • 318 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1983 • 247 citations

Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.

1982 • 240 citations

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.

1975 • 235 citations

Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.

1976 • 219 citations

Regulation of adenylate cyclase of human platelet membranes by forskolin.

1982 • 178 citations

Use of a novel rapid preparation of fat-cell plasma membranes employing Percoll to investigate the effects of insulin and adrenaline on membrane protein phosphorylation within intact fat-cells

1980 • 177 citations

beta-adrenergic receptors in rat liver: effects of adrenalectomy.

1976 • 150 citations

Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.

1979 • 142 citations

Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells.

1978 • 130 citations

Guanosine 5'-(beta, gamma-imido)triphosphate inhibition of forskolin-activated adenylate cyclase is mediated by the putative inhibitory guanine nucleotide regulatory protein.

1982 • 123 citations

Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.

1980 • 118 citations

Acquisition of a beta-adrenergic response by adult rat hepatocytes during primary culture.

1983 • 117 citations

Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

1982 • 115 citations

Hormones, Receptors, and Cyclic AMP: Their Role in Target Cell Refractoriness

1980 • 108 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.

1980 • 92 citations

Glycogenolytic response to glucagon of cultured fetal hepatocytes. Refractoriness following prior exposure to glucagon.

1975 • 86 citations

Differences in the forskolin activation of adenylate cyclases in wild-type and variant lymphoma cells.

1982 • 79 citations

Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex.

1983 • 75 citations

Interaction of epidermal growth factor with adult rat liver parenchymal cells in primary culture

1980 • 74 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.

1982 • 68 citations

Induction and decay of glucagon-induced amino acid transport in primary cultures of adult rat liver cells: paradoxical effects of cycloheximide and puromycin.

1976 • 66 citations

Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.

1980 • 60 citations

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

1979 • 59 citations

Effect of Feeding and Fasting on the Early Steps of Glucagon Action in Isolated Rat Liver Cells

1976 • 54 citations

Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.

1981 • 48 citations

The absence of desensitization in the beta adrenergic receptors of turkey reticulocytes and erythrocytes and its possible origin

1978 • 46 citations

Regulation of the glucagon receptor by physiological hyperglucagonaemia

1978 • 45 citations

3':5'-cyclic AMP: independent induction of amino acid transport by epinephrine in primary cultures of adult rat liver cells.

1977 • 43 citations

Functional Desensitisation of β-Adrenergic Receptors of Avian Erythrocytes by Catecholamines and Adenosine 3′,5′-Phosphate

1980 • 41 citations

N6,O2'-Dibutyryl cyclic AMP and cholera toxin-induced beta-adrenergic receptor loss in cultured cells.

1982 • 29 citations

Direct Evidence of a Glucagon-Dependent Regulation of the Concentration of Glucagon Receptors in the Liver

1982 • 29 citations

Desensitization of Primary Cultures of Adult Rat Liver Parenchymal Cells to Stimulation of Adenosine 3′,5′-Monophosphate Production by Glucagon and Epinephrine*

1980 • 27 citations

Functional alterations in components of pigeon erythrocyte adenylate cyclase following desensitization to isoproterenol.

1981 • 24 citations

Blockade of heterologous desensitization of prostate adenylate cyclase without blockade of homologous down regulation of receptors or loss of GTP regulation of agonist binding.

1983 • 10 citations

On the mechanism of isoproterenol-induced desensitization of adenylate cyclase in cultured differentiated hepatocytes

1982 • 8 citations

Requirement of Prolonged Presence of a High Intracellular Level of Cyclic AMP for Induction of Serine Dehydratase in Primary Cultured Rat Hepatocytes1

1983 • 8 citations