Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Interaction of Vibrio cholerae enterotoxin with cell membranes

1973 • 531 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.

1978 • 281 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones.

1976 • 238 citations

Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.

1976 • 219 citations

Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes.

1977 • 177 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.

1979 • 171 citations

The synthesis of β-adrenergic receptors in cultured human lung cells: Induction by glucocorticoids

1980 • 158 citations

Guanine nucleotide‐controlled interactions between components of adenylate cyclase

1979 • 144 citations

Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells.

1978 • 130 citations

The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.

1980 • 126 citations

Reconstitution of cholera toxin-activated adenylate cyclase.

1978 • 98 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

Mechanism of action of cholera toxin: Studies on the lag period

1980 • 82 citations

Hydrodynamic properties of the regulatory component of adenylate cyclase.

1980 • 81 citations

Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.

1981 • 75 citations

Hormone-induced Desensitisation of Hormonal Control of Cyclic AMP Levels in Human Diploid Fibroblasts

1973 • 72 citations

Mode of Action of Cholera Toxin: Stabilization of Catecholamine-Sensitive Adenylate Cyclase in Turkey Erythrocytes

1974 • 61 citations

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

1979 • 59 citations

Synthesis and uptake of gangliosides by choleragen-responsive human fibroblasts

1977 • 58 citations

Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.

1981 • 48 citations

Increase in the size of soluble brain adenylate cyclase with activation by guanosine 5'-(beta, gamma-imino)triphosphate.

1980 • 48 citations

ADP ribosylation of membrane proteins from human fibroblasts. Effect of prior exposure of cells to choleragen.

1981 • 41 citations

Effects of cholera enterotoxin on catecholamine-stimulated changes in cation fluxes, cell volume, and cyclic AMP levels in the turkey erythrocyte.

1977 • 39 citations

Modification of adenylate cyclase structure and function by ammonium sulfate.

1981 • 21 citations

Soluble adenylate cyclase from thyroid membranes

1978 • 20 citations

Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes

1980 • 20 citations

Appearance of beta-adrenergic receptors and catecholamine-responsive adenylate cyclase activity during fusion of avian embryonic muscle cells.

1980 • 19 citations

Preactivation as a determinant for the size of thyroid adenylate cyclase.

1980 • 18 citations

Regulation of adenosine 3‘:5‘-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins.

1978 • 18 citations

Adenylate cyclase and cyclic AMP through the cell cycle of Tetrahymena

1979 • 13 citations

Effects of choleragen on hormonal responsiveness of adenylate cyclase in human fibroblasts and rat fat cells

1976 • 12 citations

Cholera-toxin-dependent ADP-ribosylation of the adenylate cyclase regulatory protein in turkey erythrocyte membranes

1981 • 8 citations