Thrombin Perturbs Neurite Outgrowth and Induces Apoptotic Cell Death in Enriched Chick Spinal Motoneuron Cultures through Caspase Activation

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

1992 • 638 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading

1981 • 567 citations

A series of normal stages in the development of the chick embryo

1992 • 530 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells

1980 • 424 citations

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1989 • 359 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Prothrombin mRNA is expressed by cells of the nervous system

1991 • 337 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Thrombin modulates and reverses neuroblastoma neurite outgrowth.

1988 • 318 citations

Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

1997 • 303 citations

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults

1995 • 272 citations

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

1992 • 245 citations

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA

1995 • 228 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Cell death of motoneurons in the chick embryo spinal cord

1984 • 203 citations

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin‐1

1990 • 198 citations

Molecular cloning and expression of a novel adhesion molecule, SC1

1991 • 193 citations

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

1992 • 188 citations

Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

1997 • 169 citations

Cell Death During Development Of The Nervous System

1991 • 168 citations

Neurite outgrowth in individual neurons of a neuronal population is differentially regulated by calcium and cyclic AMP

1988 • 164 citations

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture

1986 • 157 citations

Released protease-nexin regulates cellular binding, internalization, and degradation of serine proteases.

1981 • 155 citations

Secreted forms of β‐amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

1994 • 154 citations

Cell death of motoneurons in the chick embryo spinal cord. II. A quantitative and qualitative analysis of degenerationin the ventral root, including evidence for axon outgrowth and limb innervation prior to cell death

1978 • 154 citations

Induction of CPP32-like Activity in PC12 Cells by Withdrawal of Trophic Support

1996 • 146 citations

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.

1989 • 144 citations

Variable and multiple expression of Protease Nexin-1 during mouse organogenesis and nervous system development

1993 • 136 citations

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

1997 • 128 citations

Development of Hirudin as an Antithrombotic Agent

1989 • 123 citations

A Glia-Derived Nexin Promotes Neurite Outgrowth in Cultured Chick Sympathetic Neurons

1988 • 122 citations

Induction of glia-derived nexin after lesion of a peripheral nerve

1989 • 114 citations

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

1995 • 114 citations

Methods of Preparation for Electron Microscopy

1987 • 112 citations

Differential vulnerability of microtubule components in cerebral ischemia

1990 • 107 citations

Protease‐Activated Receptor‐2 (PAR‐2) Is Present in the Rat Hippocampus and Is Associated with Neurodegeneration

1997 • 107 citations

Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons.

1998 • 104 citations

A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.

1995 • 96 citations

Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture

1994 • 90 citations

Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture

1987 • 87 citations

Differential phenotypic expression induced in cultured rat astroblasts by acidic fibroblast growth factor, epidermal growth factor, and thrombin

1989 • 87 citations

Thrombin-Elicited Contractile Responses of Aortic Smooth Muscle

1985 • 86 citations

Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors.

1993 • 86 citations

Cells regulate their mitogenic response to thrombin through release of protease nexin

1982 • 82 citations

Expression of the thrombin receptor mRNA in rat brain.

1994 • 82 citations

Neurite outgrowth activity of protease nexin‐1 on neuroblastoma cells requires thrombin inhibition

1990 • 80 citations

Forging a Path to Cell Death

1996 • 75 citations

Glia‐derived nexin/protease nexin‐1 is expressed by a subset of neurons in the rat brain

1994 • 73 citations

Thrombin, Its Receptor and Protease Nexin I, Its Potent Serpin, in the Nervous System

1996 • 70 citations

Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death

1994 • 68 citations

Inhibitors of Trypsin‐Like Serine Proteases Inhibit Processing of the Caspase Nedd‐2 and Protect PC12 Cells and Sympathetic Neurons from Death Evoked by Withdrawal of Trophic Support

1997 • 62 citations

What do we really know about amyotrophic lateral sclerosis?

1992 • 52 citations

Enhancement of Neurite Outgrowth Following Calpain Inhibition Is Mediated by Protein Kinase C

1995 • 46 citations

A new membrane antigen revealed by monoclonal antibodies is associated with motoneuron axonal pathways

1989 • 44 citations

Involvement of the “tethered-ligand” receptor in thrombin inhibition of platelet adenylate cyclase

1992 • 41 citations

The Coagulation Explosion^a

1994 • 34 citations

Vitronectin is the major serum protein essential for NGF-mediated neurite outgrowth from PC12 cells

1992 • 33 citations

Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors

1993 • 32 citations

Activation of serpins and their cognate proteases in muscle after crush injury

1994 • 31 citations

Serine proteases and their serpin inhibitors in Alzheimer's disease

1994 • 30 citations

Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons

1998 • 29 citations

Proteases in biological control and biotechnology

1986 • 23 citations

Extravascular Proteolysis and the Nervous System: Serine Protease/Serpin Balance

1994 • 21 citations

The Coagulation Explosion

1995 • 15 citations

Quantitative reverse transcriptase PCR to gauge increased protease-activated receptor 1 (PAR-1) mRNA copy numbers in thewobbler mutant mouse

1998 • 11 citations

The inhibition of thrombin and chymotrypsin by heparin-cofactor II

1992 • 10 citations

Inhibition of neuronal surface proteases decreases the requirement for GAP-43 in neurite outgrowth

1995 • 5 citations