The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Signal sequences

1985 • 2,179 citations

Turns in Peptides and Proteins

1985 • 1,658 citations

The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions

1971 • 1,417 citations

Hydrophobicity of Amino Acid Residues in Globular Proteins

1985 • 1,168 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

A simplified representation of protein conformations for rapid simulation of protein folding

1976 • 1,099 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes

1975 • 863 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

PRINCIPLES THAT DETERMINE THE STRUCTURE OF PROTEINS

1984 • 645 citations

Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure

1983 • 401 citations

Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase

1987 • 375 citations

Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli

1980 • 268 citations

Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein

1982 • 236 citations

Conformations of Signal Peptides Induced by Lipids Suggest Initial Steps in Protein Export

1986 • 225 citations

Uncoupling Translocation from Translation: Implications for Transport of Proteins Across Membranes

1986 • 195 citations

On the Hydrophobic Nature of Signal Sequences

1981 • 193 citations

Secretion in yeast: translocation and glycosylation of prepro-α-factor in vitro can occur via an ATP-dependent post-translational mechanism

1986 • 185 citations

The human glucose transporter can insert posttranslationally into microsomes

1986 • 176 citations

Importance of secondary structure in the signal sequence for protein secretion.

1983 • 152 citations

In Vivo Function and Membrane Binding Properties Are Correlated for Escherichia coli lamB Signal Peptides

1985 • 130 citations

Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent.

1987 • 124 citations

Exploring the conformational roles of signal sequences: synthesis and conformational analysis of .lambda. receptor protein wild-type and mutant signal peptides

1984 • 117 citations

Conformational studies of the synthetic precursor-specific region of preproparathyroid hormone.

1980 • 109 citations

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide

1986 • 98 citations

Protein Translocation Across and Integration into Membrane

1986 • 91 citations

Yeast carboxypeptidase Y can be translocated and glycosylated without its amino-terminal signal sequence.

1987 • 80 citations

Chapter 2 Structure and Function of the Signal Peptide

1985 • 80 citations

Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems.

1985 • 73 citations

Post-translational export of maltose-binding protein in Escherichia coli strains harboring malE signal sequence mutations and either prl+ or prl suppressor alleles.

1985 • 63 citations

Translocation of nascent secretory proteins across membranes can occur late in translation.

1986 • 62 citations

Chapter 3 The Use of Genetic Techniques to Analyze Protein Export in Escherichia coli

1985 • 50 citations

Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane

1987 • 47 citations

A signal sequence mutant defective in export of ribose-binding protein and a corresponding pseudorevertant isolated without imposed selection.

1985 • 28 citations

Posttranslational translocation of influenza virus hemagglutinin across microsomal membranes.

1987 • 20 citations

Membrane transport and neuroreceptors

1980 • 9 citations