Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Stepwise dismantling of adenovirus 2 during entry into cells

1993 • 810 citations

Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy

1996 • 777 citations

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism

1996 • 392 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

1994 • 373 citations

Virus-Receptor Interaction in an Adenovirus System

1968 • 343 citations

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

1996 • 327 citations

Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

1996 • 293 citations

Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery

1995 • 292 citations

Multiple adenovirus serotypes use alpha v integrins for infection

1994 • 284 citations

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution

1994 • 281 citations

Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli

1994 • 252 citations

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C

1990 • 248 citations

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

1996 • 237 citations

Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs.

1995 • 208 citations

Cell-binding domain of adenovirus serotype 2 fiber

1994 • 195 citations

Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain

1995 • 192 citations

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

1995 • 188 citations

Deletion of the E4 region of the genome produces adenovirus DNA concatemers.

1994 • 150 citations

Addition of a short peptide ligand to the adenovirus fiber protein.

1995 • 149 citations

Gene therapy using adenoviral vectors

1994 • 134 citations

Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time

1996 • 125 citations

Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers.

1995 • 77 citations

A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor

1996 • 72 citations