The role of the cathepsin D propeptide in sorting to the lysosome.

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway

1990 • 972 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Antibodies to the Golgi complex and the rough endoplasmic reticulum.

1982 • 418 citations

Expression of recombinant plasmids in mammalian cells Is enhanced by sodium butyrate

1983 • 380 citations

Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide

1987 • 329 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Evolution in the structure and function of aspartic proteases

1987 • 298 citations

Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.

1988 • 287 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes.

1981 • 235 citations

Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster.

1982 • 209 citations

Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.

1981 • 188 citations

Is there a mechanism for introducing acid hydrolases into liver lysosomes that is independent of mannose 6-phosphate recognition? evidence from I-cell disease

1982 • 169 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Interaction of human cathepsin D with the inhibitor pepstatin

1976 • 150 citations

Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes.

1984 • 150 citations

Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis

1978 • 148 citations

Deficiency of UDP-N-acetylglucosamine: Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients

1982 • 147 citations

Cathepsin D isozymes from porcine spleens. Large scale purification and polypeptide chain arrangements.

1979 • 127 citations

Synthesis, purification, and active site mutagenesis of recombinant porcine pepsinogen

1989 • 112 citations

Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.

1991 • 106 citations

Structures at the proteolytic processing region of cathepsin D.

1988 • 93 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins.

1989 • 72 citations

Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme

1989 • 64 citations

Proteins involved in vesicular transport and membrane fusion

1991 • 47 citations

Expression and Refolding of Recombinant Human Fibroblast Procathepsin D

1990 • 32 citations

Recombinant bovine α-lactalbumin obtained by limited proteolysis of a fusion protein expressed at high levels in Escherichia coli

1989 • 29 citations

Nonhuman cells correctly sort and process the human lysosomal enzyme cathepsin D

1989 • 23 citations

The pro‐peptide is not necessary for active renin secretion from transfected mammalian cells

1989 • 21 citations

Expression of the Yeast Aspartyl Protease, Proteinase A

1989 • 11 citations

Transcription and expression of the Herpes simplex virus tk gene inserted into proviral sequences of feline leukemia virus

1984 • 6 citations