Enhancement of Complement Activation and Cytolysis of Human IgG3 by Deletion of Hinge Exons

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Coupling of enzymes to proteins with glutaraldehyde

1969 • 1,442 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

1984 • 1,002 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

1987 • 615 citations

The binding site for C1q on IgG

1988 • 556 citations

Production of functional chimaeric mouse/human antibody

1984 • 539 citations

Immunoglobulin G: Functional sites

1985 • 442 citations

Crystallographic structure studies of an IgG molecule and an Fc fragment

1976 • 416 citations

Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: Results of an IUIS/WHO collaborative study

1985 • 393 citations

A hapten-specific chimaeric IgE antibody with human physiological effector function

1985 • 289 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.

1988 • 281 citations

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

1988 • 269 citations

IgG subclasses--a review.

1987 • 211 citations

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.

1975 • 154 citations

Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C_γgenes

1986 • 145 citations

Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.

1977 • 136 citations

Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins.

1990 • 123 citations

Segmental flexibility of immunoglobulin G antibody molecules in solution: a new interpretation

1981 • 114 citations

Immunoglobulin structure and effector functions

1978 • 111 citations

Intermolecular disulfide bonding in IgM: effects of replacing cysteine residues in the mu heavy chain.

1989 • 104 citations

The IgG Subclass Pattern of Complement Activation Depends on Epitope Density and Antibody and Complement Concentration

1989 • 100 citations

Unusual Molecular Properties of Human IgG3 Proteins Due to an Extended Hinge Region

1974 • 76 citations

Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.

1982 • 65 citations

Three-dimensional structure of the Mcg IgG1 immunoglobulin☆

1983 • 56 citations

The three-dimensional structure of a human IgGl immunoglobulin at 4 Å resolution: a computer fit of various structural domains on the electron density map

1982 • 26 citations

The solution shapes of IgG3 immunoglobulin and its Fch and Fc fragments. A small-angle x-ray scattering study

1980 • 21 citations

Conformation of the Hinge Region and Various Fragments of Human IgG3

1975 • 20 citations

C3, C4, and the terminal complement complex differ from C1q by binding predominantly to the antigenic part of solid phase immune complexes.

1990 • 9 citations