Inactivation of the 2‐oxo acid dehydrogenase complexes upon generation of intrinsic radical species

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Alpha-lipoic acid as a biological antioxidant

1995 • 1,920 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

The pharmacology of the antioxidant lipoic acid

1997 • 817 citations

Swinging Arms and Swinging Domains in Multifunctional Enzymes: Catalytic Machines for Multistep Reactions

2000 • 586 citations

Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae

2000 • 420 citations

Domains, motifs, and linkers in 2-oxo acid dehydrogenase multienzyme complexes: a paradigm in the design of a multifunctional protein

1991 • 419 citations

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen

1969 • 419 citations

An Electron Spin Resonance Study of the Spin Adducts of OH and HO₂ Radicals with Nitrones in the Ultraviolet Photolysis of Aqueous Hydrogen Peroxide Solutions

1974 • 410 citations

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1988 • 406 citations

Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

2002 • 394 citations

Mitochondrial Oxidative Stress Plays a Key Role in Aging and Apoptosis

2000 • 382 citations

Structure-function relationships in dihydrolipoamide acyltransferases.

1990 • 367 citations

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

1998 • 350 citations

The Reactivity of Flavoproteins with Sulfite

1969 • 342 citations

Oxidative Stress Promotes Specific Protein Damage inSaccharomyces cerevisiae

2000 • 321 citations

Mitochondrial Aconitase Is a Source of Hydroxyl Radical

2000 • 306 citations

Lipoic and Dihydrolipoic Acids as Antioxidants. a Critical Evaluation

1994 • 301 citations

The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes

1982 • 283 citations

Intermediates in the catalytic action of lipoyl dehydrogenase (diaphorase)

1960 • 239 citations

Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein

1969 • 223 citations

Reactive oxygen species as cellular messengers

1995 • 218 citations

Purification of 2-oxo acid dehydrogenase multienzyme complexes from ox heart by a new method

1980 • 201 citations

An immunohistochemical study on ?-ketoglutarate dehydrogenase complex in Parkinson's disease

1994 • 192 citations

Thiamine‐Dependent Enzyme Changes in the Brains of Alcoholics: Relationship to the Wernicke‐Korsakoff Syndrome

1993 • 188 citations

The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria

1998 • 169 citations

Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase

2001 • 155 citations

On spin trapping hydroxyl and hydroperoxyl radicals

1978 • 153 citations

Peroxynitrite‐mediated oxidation of albumin to the protein‐thiyl free radical

1994 • 146 citations

A method for the detection of superoxide in biological systems

1982 • 138 citations

[15] Sulfur-centered free radicals

1990 • 134 citations

Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes.

1999 • 129 citations

Contribution of different enzymes to flavoprotein fluorescence of isolated rat liver mitochondria

1985 • 123 citations

Brain protein and α‐ketoglutarate dehydrogenase complex activity in alzheimer‐s disease

1996 • 119 citations

Mitochondria in the Programmed Death Phenomena; A Principle of Biology: “It Is Better to Die than to be Wrong”

2000 • 112 citations

The cytotoxic lipid peroxidation product, 4‐hydroxy‐2‐nonenal, specifically inhibits decarboxylating dehydrogenases in the matrix of plant mitochondria

2000 • 111 citations

α-Ketoglutaric Dehydrogenase

1961 • 109 citations

Acyl group and electron pair relay system: A network of interacting lipoyl moieties in the pyruvate and α-ketoglutarate dehydrogenase complexes from Escherichia coli

1977 • 108 citations

Decay and fate of the hydroxyl radical adduct of .alpha.-phenyl-N-tert-butylnitrone (PBN) in aqueous media

1991 • 107 citations

The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition reactions and formation of thiyl radical intermediates.

1992 • 107 citations

Inactivation of Aconitase and Oxoglutarate Dehydrogenase in Skeletal Musclein Vitroby Superoxide Anions and/or Nitric Oxide

1998 • 102 citations

Superoxide generation by the respiratory chain of tumor mitochondria

1987 • 100 citations

Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediated destruction.

1990 • 93 citations

On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediate

1988 • 92 citations

Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. The confounding problem of adventitious iron bound to xanthine oxidase.

1990 • 91 citations

Rapid intramolecular coupling of active sites in the pyruvate dehydrogenase complex of Escherichia coli : Mechanism for rate enhancement in a multimeric structure

1978 • 78 citations

Reactive Oxygen Species-Mediated Inactivation of Pyruvate Dehydrogenase

1996 • 76 citations

Substrate specificity of the pyruvate dehydrogenase complex from Escherichia coli.

1981 • 75 citations

Mechanism of the Clostridium thermoaceticum Pyruvate:Ferredoxin Oxidoreductase: Evidence for the Common Catalytic Intermediacy of the Hydroxyethylthiamine Pyropyrosphate Radical

1997 • 71 citations

Biochemical Characterization of Lucigenin (Bis-N-methylacridinium) as a Chemiluminescent Probe for Detecting Intramitochondrial Superoxide Anion Radical Production

1999 • 69 citations

Thiyl radicals - formation during peroxidase-catalyzed metabolism of acetaminophen in the presence of thiols

1984 • 68 citations

Phenoxyl Radical-Induced Thiol-Dependent Generation of Reactive Oxygen Species: Implications for Benzene Toxicity

1995 • 57 citations

Ion pair formation in pig heart lipoamide dehydrogenase: rationalization of pH profiles for reactivity of oxidized enzyme with dihydrolipoamide and 2-electron-reduced enzyme with lipoamide and iodoacetamide.

1977 • 55 citations

Spin-label study of the mobility of enzyme-bound lipoic acid in the pyruvate dehydrogenase multienzyme complex of Escherichia coli

1976 • 54 citations

Evidence against the Generation of Free Hydroxyl Radicals from the Interaction of Copper,Zinc-Superoxide Dismutase and Hydrogen Peroxide

1999 • 52 citations

Quantification of Superoxide Radical Formation in Intact Vascular Tissue Using aCypridinaLuciferin Analog as an Alternative to Lucigenin

1998 • 50 citations

Electron transfer properties of active aldehydes derived from thiamin coenzyme analogues

1997 • 50 citations

The reduction of nitroso-spin traps in chemical and biological sysetms. A cautionary note

1979 • 49 citations

Electrochemical oxidation of enamines related to the key intermediate on thiamin diphosphate dependent enzymic pathways: evidence for one-electron oxidation via a thiazolium cation radical

1990 • 47 citations

Spin labeling of protein sulfhydryl groups by spin trapping a sulfur radical: Application to bovine serum albumin and myosin

1983 • 44 citations

Free radical intermediates in the reaction of pyruvate:ferredoxin oxidoreductase in Tritrichomonas foetus hydrogenosomes.

1987 • 43 citations

Elementary steps in the reaction mechanism of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: kinetics of acetylation and deacetylation

1980 • 41 citations

Thiyl free radical production with hematoporphyrin derivative, cysteine and light: a spin‐trapping study

1984 • 40 citations

Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine

1990 • 39 citations

Thioredoxin reduction dependent on α‐ketoacid oxidation by α‐ketoacid dehydrogenase complexes

1993 • 39 citations

ESR and HPLC-EC Analysis of the Interaction of Hydroxyl Radical with DMSO: Rapid Reduction and Quantification of POBN and PBN Nitroxides

1998 • 38 citations

Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death

1998 • 38 citations

Inactivation of 2-Oxoglutarate Dehydrogenase in Rat Liver Mitochondria by Its Substrate and t-Butyl Hydroperoxide

1987 • 36 citations

Interaction of thioredoxins with target proteins: Role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2‐oxoacid dehydrogenase complexes

1999 • 36 citations

Redox Properties of Protein Disulfide Bond in Oxidized Thioredoxin and Lysozyme: A Pulse Radiolysis Study

2000 • 36 citations

Kinetic analysis of the role of lipoic acid residues in the pyruvate dehydrogenase multienzyme complex of Escherichia coli

1980 • 35 citations

Symmetry and Asymmetry of the Pyruvate Dehydrogenase Complexes from Azotobacter vinelandii and Escherichia coli as Reflected by Fluorescence and Spin-Label Studies

1976 • 34 citations

[33] Thiyl free radical metabolites of thiol drugs, glutathione, and proteins

1990 • 34 citations

Molecular aspects of the removal of ferritin-bound iron bydl-dihydrolipoate

1989 • 33 citations

Studies on the lipoic acid free radical

1974 • 31 citations

Elementary steps in the reaction mechanism of the .alpha.-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli: kinetics of succinylation and desuccinylation

1984 • 31 citations

Intermediates in Reductive Transacetylation Catalyzed by Pyruvate Dehydrogenase Complex^a

1989 • 30 citations

The mechanism of the quinone reductase reaction of pig heart lipoamide dehydrogenase

1990 • 30 citations

ChemInform Abstract: Decay and Fate of the Hydroxyl Radical Adduct of α‐Phenyl‐N‐tert‐ butylnitrone in Aqueous Media.

1992 • 26 citations

A computer model analysis of the active-site coupling mechanism in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.

1983 • 24 citations

Using lipoate enantiomers and thioredoxin to study the mechanism of the 2‐oxoacid‐dependent dihydrolipoate production by the 2‐oxoacid dehydrogenase complexes

1995 • 21 citations

Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-l-cysteine

1999 • 21 citations

Dihydrolipoamide-Mediated Redox Cycling of Quinones

1993 • 20 citations

Reduction of aryl-nitroso compounds by pyridine and flavin coenzymes

1989 • 18 citations

Increased catalytic performance of the 2-oxoacid dehydrogenase complexes in the presence of thioredoxin, a thiol–disulfide oxidoreductase

2000 • 17 citations

Reduction of nitrofuran compounds by heart lipoamide dehydrogenase: role of flavin and the reactive disulfide groups.

1992 • 14 citations

The Interaction Between Lipoamide Dehydrogenase and the Peripheral‐Component‐Binding Domain from the Azotobacter Vinelandii Pyruvate Dehydrogenase Complex

1995 • 13 citations

Magnetic circular dichroism studies on the active-site flavin of lipoamide dehydrogenase

1980 • 11 citations

Spin trapping the cysteine thiyl radical with phenyl-N-t-butylnitrone

1988 • 11 citations

Reactions of oxidizing and reducing radical probes with lipoamide dehydrogenase

1980 • 7 citations

ChemInform Abstract: Redox Behavior of Active Aldehydes Derived from Thiamin Coenzyme Analogues.

1997 • 2 citations

ChemInform Abstract: Electron Transfer Properties of Active Aldehydes Derived from Thiamin Coenzyme Analogues

1998 • 1 citations

Deleted Work

1955 • 0 citations