Melanin biosynthesis patterns following hormonal stimulation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Enzymatic control of pigmentation in mammals

1991 • 747 citations

BIOCHEMISTRY OF MELANIN FORMATION

1950 • 623 citations

Mammalian Tyrosinase Catalyzes Three Reactions in the Biosynthesis of Melanin

1982 • 574 citations

A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

1992 • 552 citations

Mammalian tyrosinase—The critical regulatory control point in melanocyte pigmentation

1987 • 439 citations

Ultraviolet radiation directly induces pigment production by cultured human melanocytes

1987 • 311 citations

Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.

1985 • 288 citations

Regulation of tyrosinase in human melanocytes grown in culture.

1983 • 288 citations

Interleukins 1α and 6 and Tumor Necrosis Factor-α Are Paracrine Inhibitors of Human Melanocyte Proliferation and Melanogenesis

1991 • 252 citations

New regulators of melanin biosynthesis and the autodestruction of melanoma cells

1980 • 244 citations

Tyrosinases from two different loci are expressed by normal and by transformed melanocytes.

1991 • 233 citations

Factors Regulating Growth And Pigmentation Of Melanoma Cells

1976 • 219 citations

[22] Mammalian monophenol monooxygenase (tyrosinase): Purification, properties, and reactions catalyzed

1987 • 217 citations

Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation

1976 • 208 citations

Dopachrome Conversion: A Possible Control Point in Melanin Biosynthesis

1980 • 190 citations

Regulation of mammalian melanogenesis I: partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase

1990 • 175 citations

Control of Phenotypic Expresssion of Cultured Melanoma Cells by Melanocyte Stimulating Hormones

1973 • 160 citations

Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells

1975 • 157 citations

Effect of metal ions on the rearrangement of dopachrome

1987 • 154 citations

Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.

1990 • 146 citations

After Dopachrome?

1991 • 143 citations

Mutational mapping of the catalytic activities of human tyrosinase.

1992 • 139 citations

Human Melanogenesis is Stimulated by Diacylglycerol

1989 • 138 citations

Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.

1988 • 135 citations

Pigment Production in Murine Melanoma Cells Is Regulated by Tyrosinase, Tyrosinase-Related Protein 1 (TRP1), DOPAchrome Tautomerase (TRP2), and a Melanogenic Inhibitor

1993 • 134 citations

Dopachrome Oxidoreductase: A New Enzyme in the Pigment Pathway

1984 • 133 citations

Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures.

1987 • 123 citations

Pigment content of cultured human melanocytes does not correlate with tyrosinase message level

1991 • 113 citations

Molecular Cascades in UV Induced Melanogenesis: A Central Role for Melanotropins?

1992 • 108 citations

Tyrosinase activity and abundance in Cloudman melanoma cells

1984 • 107 citations

Specific Identification of an Authentic Clone for Mammalian Tyrosinase

1989 • 106 citations

Effects of Combined Treatment with Interferon and Mezerein on Melanogenesis and Growth in Human Melanoma Cells

1985 • 105 citations

Melanocyte-stimulating hormone, tyrosinase activity and the regulation of eumelanogenesis and phaeomelanogenesis in the hair follicular melanocytes of the mouse

1986 • 99 citations

Loss of melanogenic properties in tyrosinases induced by glucosylation inhibitors within malignant melanoma cells.

1982 • 98 citations

Function of dopachrome oxidoreductase and metal ions in dopachrome conversion in the eumelanin pathway

1988 • 96 citations

The role of RNA and protein synthesis in mediating the action of MSH on mouse melanoma cells

1979 • 81 citations

Synthesis and Characterization of Melanins From Dihydroxyindole‐2‐Carboxylic Acid and Dihydroxyindole

1992 • 80 citations

Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system

1977 • 76 citations

In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins.

1987 • 76 citations

5,6-Dihydroxyindole-2-carboxylic acid is incorporated in mammalian melanin

1992 • 72 citations

Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di‐acyl glycerol but not TPA

1990 • 71 citations

Stimulation of Human Melanocytes by Vitamin D3 Possibly Mediates Skin Pigmentation After Sun Exposure

1988 • 70 citations

Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells.

1989 • 62 citations

Structural/functional relationships between internal and external MSH receptors: Modulation of expression in Cloudman melanoma cells by UVB radiation

1991 • 59 citations

Hormonal effects of vitamin D₃ on epidermal melanocytes

1988 • 55 citations

Regulation of cell shape in the Cloudman melanoma cell line.

1987 • 50 citations

Regulation of mammalian melanogenesis by tyrosinase inhibition

1989 • 44 citations

α-MSH and Other Melanogenic Activators Mediate Opposite Effects of Tyrosinase and Dopachrome Tautomerase in B16/F10 Mouse Melanoma Cells

1992 • 42 citations

From Gene to Protein: Determination of Melanin Synthesis

1993 • 39 citations

Internal binding sites for MSH: Analyses in wild‐type and variant Cloudman melanoma cells

1990 • 35 citations

Interferon inhibits melanogenesis in b-16 mouse melanoma cells

1981 • 33 citations

Melanocyte-stimulating hormone and the regulation of tyrosinase activity in hair follicular melanocytes of the mouse

1986 • 33 citations

Importance of Glycoproteins in the Initiation of Melanogenesis: An Electron Microscopic Study of b-16 Melanoma Cells After Release from Inhibition of Glycosylation

1986 • 32 citations

Expression of melanocyte stimulating hormone receptors correlates with mammalian pigmentation, and can be modulated by interferons

1988 • 32 citations

Actions of melanotropins on mouse melanoma cell growth in vitro.

1986 • 32 citations

Decreased dopachrome oxidoreductase activity in yellow mice

1985 • 30 citations

Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation

1982 • 25 citations

A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function.

1989 • 23 citations

Differentiation apparently repressed by the nucleus

1987 • 18 citations

5,6-Dihydroxyindole oxidation by mammalian, mushroom and amphibian tyrosinase preparations

1985 • 16 citations

Stimulation of melanogenesis by cholecalciferol in cultured human melanocytes : A possible mechanism underlying pigmentation after ultraviolet irradiation.

1986 • 14 citations

Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells Evidence for a differential induction of two distinct isoenzymes

1992 • 12 citations