The Structure of the HMG Box and Its Interaction with DNA

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

1990 • 3,134 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°

1991 • 1,109 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Genetic evidence equating SRY and the testis-determining factor

1990 • 972 citations

HMG domain proteins: architectural elements in the assembly of nucleoprotein structures

1994 • 813 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

1991 • 627 citations

Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

1989 • 596 citations

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

1991 • 545 citations

Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins

1991 • 538 citations

Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin

1992 • 492 citations

DNA Binding Activity of Recombinant SRY from Normal Males and XY Females

1992 • 454 citations

SRY, like HMG1, recognizes sharp angles in DNA.

1992 • 439 citations

SRY AND SEX DETERMINATION IN MAMMALS

1993 • 422 citations

Structure of the HMG box motif in the B-domain of HMG1.

1993 • 403 citations

Four mating-type genes control sexual differentiation in the fission yeast.

1988 • 388 citations

Definition of a consensus DNA binding site for SRY

1994 • 381 citations

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

1991 • 372 citations

Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

1991 • 352 citations

Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

1993 • 340 citations

Ancestry and diversity of the HMG box superfamily

1993 • 328 citations

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

1993 • 327 citations

A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria.

1991 • 325 citations

DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein.

1992 • 322 citations

DNA binding specificity of homeodomains

1991 • 300 citations

DNA unwinding produced by site-specific intrastrand crosslinks of the antitumor drug cis-diamminedichloroplatinum(II)

1991 • 289 citations

X-ray analysis (1. 4-Å resolution) of avian pancreatic polypeptide: Small globular protein hormone

1981 • 279 citations

Solution structure of a DNA-binding domain from HMG1

1993 • 275 citations

DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1.

1991 • 265 citations

An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

1992 • 260 citations

The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins.

1992 • 259 citations

A signature for the HMG‐1 box DNA‐binding proteins

1993 • 258 citations

Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal

1992 • 253 citations

SOX3 is an X-linked gene related to SRY

1993 • 250 citations

Neurospora crassa a mating-type region.

1990 • 250 citations

Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.

1992 • 246 citations

Nonhistone Proteins HMG ₁ and HMG ₂ Change the DNA Helical Structure

1978 • 243 citations

Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

1992 • 218 citations

Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF

1994 • 216 citations

Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element

1986 • 215 citations

Promotion and Regulation of Ribosomal Transcription in Eukaryotes by RNA Polymerase

1995 • 212 citations

DNA-binding properties of the product of the testis-determining gene and a related protein

1991 • 200 citations

High-mobility-group 1 protein mediates DNA bending as determined by ring closures.

1993 • 193 citations

A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1

1989 • 188 citations

The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1

1993 • 185 citations

Ixr1, a Yeast Protein That Binds to Platinated DNA and Confers Sensitivity to Cisplatin

1993 • 177 citations

DNA binding properties of an HMG1-related protein from yeast mitochondria.

1992 • 175 citations

RNA and DNA binding zinc fingers in Xenopus TFIIIA

1992 • 169 citations

DNA chaperones: A solution to a persistence problem?

1994 • 168 citations

Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription.

1992 • 159 citations

A Negative Regulator of HO Transcription, SIN1 (SPT2), Is a Nonspecific DNA-Binding Protein Related to HMG1

1991 • 157 citations

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.

1993 • 155 citations

Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1.

1990 • 154 citations

SRY recognizes conserved DNA sites in sex-specific promoters.

1993 • 151 citations

Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2.

1992 • 150 citations

Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.

1992 • 149 citations

Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).

1994 • 149 citations

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.

1991 • 146 citations

Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH3) 2 (N3-cytosine) Cl]+

1990 • 145 citations

DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5

1994 • 144 citations

The interaction with DNA of wild-type and mutant fushi tarazu homeodomains.

1990 • 142 citations

Preferential affinity of high molecular weight high mobility group non-histone chromatin proteins for single-stranded DNA.

1979 • 142 citations

Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.

1993 • 141 citations

DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain

1994 • 139 citations

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

1993 • 137 citations

The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.

1991 • 131 citations

The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor, xUBF.

1989 • 130 citations

A familial mutation in the testis-determining gene SRY shared by both sexes

1992 • 121 citations

Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors.

1994 • 116 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

The specific interactions of HMG 1 and 2 with negatively supercoiled DNA are modulated by their acidic C-terminal domains and involve cysteine residues in their HMG 1/2 boxes

1993 • 107 citations

The RNA polymerase I transcription factor UBF is a sequence-tolerant HMG-box protein that can recognize structured nucleic acids

1994 • 101 citations

The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster

1994 • 100 citations

HMGs everywhere

1992 • 99 citations

HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes.

1991 • 96 citations

The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes

1991 • 94 citations

Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.

1990 • 88 citations

A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.

1991 • 77 citations

Hierarchy of binding sites for chromosomal proteins HMG 1 and 2 in supercoiled deoxyribonucleic acid

1985 • 77 citations

A high-mobility-group protein and its cDNAs from Drosophila melanogaster.

1992 • 76 citations

SRY protein enhances transcription of Fos-related antigen 1 promoter constructs.

1994 • 75 citations

Sequence-specific proton NMR assignments and solution structure of bovine pancreatic polypeptide

1992 • 75 citations

Isolation and characterization of maize cDNAs encoding a high mobility group protein displaying a HMG-box

1991 • 73 citations

Identification of a single-stranded DNA binding protein from rat liver with high mobility group protein 1.

1982 • 71 citations

The DNA sequence specificity of HMG boxes lies in the minor wing of the structure.

1994 • 70 citations

xUBF, an RNA polymerase I transcription factor, binds crossover DNA with low sequence specificity.

1994 • 66 citations

Isolation and sequence of cDNA clones coding for a member of the family of high mobility group proteins (HMG-T) in trout and analysis of HMG-T-mRNA's in trout tissues

1985 • 62 citations

TFC3: gene encoding the B-block binding subunit of the yeast transcription factor IIIC.

1992 • 62 citations

High mobility group protein 1 preferentially conserves torsion in negatively supercoiled DNA

1989 • 61 citations

Characterization of high mobility group protein binding to cisplatin-damaged DNA

1992 • 60 citations

Architectural elements in nucleoprotein complexes

1993 • 59 citations

Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction.

1993 • 57 citations

Negative Regulation of the Saccharomyces cerevisiae ANB1 Gene by Heme, as Mediated by the ROX1 Gene Product

1986 • 56 citations

Induction by torsional stress of an altered DNA conformation 5' upstream of the gene for a high mobility group protein from trout and specific binding to flanking sequences by the gene product HMG-T

1988 • 55 citations

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCRβ and TCRδ enhancers

1991 • 55 citations

Description and functional implications of a novel mutation in the sex-determining gene SRY

1994 • 48 citations

Mutational analysis of the DNA binding domain A of chromosomal protein HMG1

1994 • 48 citations

dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster

1993 • 42 citations

Insect proteins homologous to mammalian high mobility group protein 1. Characterization and DNA-binding properties.

1992 • 39 citations

Cooperative binding of the Xenopus RNA polymerase I transcription factor xUBF to repetitive ribosomal gene enhancers.

1992 • 38 citations

A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids.

1993 • 37 citations

A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus.

1993 • 37 citations

Isolation and characterization of cDNA clones encoding theDrosophilahomolog of the HMG-box SSRP family that recognizes specific DNA structures

1993 • 37 citations

The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.

1993 • 36 citations

The Saccharomyces cerevisiae ACP2 gene encodes an essential HMG1-like protein.

1988 • 34 citations

Control of sex determination in animals

1993 • 34 citations

Phylogenetic relationships of HMG box DNA-binding domains

1993 • 32 citations

Sequence and genetic analysis of NHP2: A moderately abundant high mobility group‐like nuclear protein with an essential function in Saccharomyces cerevisiae

1991 • 32 citations

Negative regulation of the Saccharomyces cerevisiae ANB1 gene by heme, as mediated by the ROX1 gene product.

1986 • 31 citations

A plant DNA binding protein shares highly conserved sequence motifs with HMG-box proteins

1991 • 29 citations

HMG proteins (1+2) form beaded structures when complexed with closed circulac DNA

1980 • 29 citations

Sequence of human HMG2 cDNA

1991 • 28 citations

The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution.

1993 • 24 citations

HMG box proteins in early T-cell differentiation.

1993 • 22 citations

Dissection of the DNA-binding Domain of Xenopus laevis TFIIIA

1993 • 21 citations

Localization of the binding region of high mobility group protein 2 to cisplatin-damaged DNA.

1993 • 17 citations

The HMG Box Motif

1992 • 17 citations

High resolution studies of the Xenopus laevis ribosomal gene promoter in vivo and in vitro.

1992 • 15 citations

The SRY gene

1993 • 15 citations

Analysis of the rat ribosomal DNA promoter: characterization of linker-scanning mutants and of the binding of UBF

1992 • 14 citations

Rat and chick cDNA clones encoding HMG-like proteins

1993 • 12 citations

Cloning and characterization of a highly conserved HMG-like protein (Pf16) gene from plasmodium falciparum

1992 • 7 citations