Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta-promoter.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

1979 • 532 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Embryonic ε and γ globin genes of a prosimian primate (Galago crassicaudatus)

1988 • 368 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes

1987 • 312 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

1985 • 235 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Human γ-globin genes silenced independently of other genes in the β-globin locus

1991 • 191 citations

Embryonic-fetal erythroid characteristics of a human leukemic cell line.

1980 • 175 citations

Structure and evolution of a human erythroid transcription factor

1990 • 160 citations

The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome.

1990 • 155 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4.

1989 • 126 citations

Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains.

1988 • 120 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

1987 • 104 citations

An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter.

1988 • 99 citations

Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei.

1989 • 79 citations

Developmentally regulated and erythroid-specific expression of the human embryonic β-globin gene in transgenic mice

1990 • 68 citations

Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice.

1987 • 68 citations

Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters

1991 • 50 citations

Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells.

1987 • 42 citations

Regulation of human fetal and adult globin genes in mouse erythroleukemia cells

1991 • 33 citations

Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.

1990 • 33 citations

Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes.

1987 • 31 citations

Expression of human gamma-globin genes in human erythroleukemia (K562) cells.

1987 • 25 citations

Upstream Gℽ-Globin and Downstream β-Globin Sequences Required for Stage-Specific Expression in Transgenic Mice

1987 • 23 citations

Roles of Fetal ^Gγ-Globin Promoter Elements and the Adult β-Globin 3′ Enhancer in the Stage-Specific Expression of Globin Genes

1990 • 6 citations