Roles of mast cell tryptase and chymase in airway function

Two types of human mast cells that have distinct neutral protease compositions.

1986 • 999 citations

Tryptase Levels as an Indicator of Mast-Cell Activation in Systemic Anaphylaxis and Mastocytosis

1987 • 775 citations

Inflammatory Mediators in Late Antigen-Induced Rhinitis

1985 • 708 citations

Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves.

1987 • 554 citations

Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells.

1987 • 504 citations

Tryptase from human pulmonary mast cells. Purification and characterization.

1981 • 428 citations

Activation of Pulmonary Mast Cells by Bronchoalveolar Allergen Challenge:In VivoRelease of Histamine and Tryptase in Atopic Subjects with and without Asthma

1988 • 352 citations

Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.

1986 • 348 citations

Nonadrenergic inhibitory nervous system in human airways

1976 • 335 citations

Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells.

1981 • 332 citations

Pavlovian Conditioning of Rat Mucosal Mast Cells to Secrete Rat Mast Cell Protease II

1989 • 317 citations

Substance P regulates the vasodilator activity of calcitonin gene-related peptide

1988 • 306 citations

Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.

1988 • 301 citations

Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.

1982 • 298 citations

Evaluation of human peripheral blood leukocytes for mast cell tryptase.

1987 • 281 citations

Vasoactive Intestinal Peptide: A Possible Transmitter of Nonadrenergic Relaxation of Guinea Pig Airways

1980 • 269 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Human mast cell heterogeneity: Histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli

1988 • 258 citations

Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases

1987 • 218 citations

The fibrinogenolytic activity of purified tryptase from human lung mast cells.

1985 • 203 citations

PROTEOLYTIC ENZYMES OF MAST CELLS*

1963 • 197 citations

Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase.

1983 • 190 citations

Secretion in dissociated human pulmonary mast cells. Evidence for solubilization of granule contents before discharge.

1980 • 186 citations

Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs.

1989 • 181 citations

Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors

1985 • 180 citations

Human lung tryptase. Purification and characterization.

1984 • 172 citations

AN ENZYME IN MAST CELLS WITH PROPERTIES LIKE CHYMOTRYPSIN

1959 • 171 citations

Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells.

1981 • 164 citations

Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response

1988 • 163 citations

Histochemical Demonstration of a Species-Specific Trypsin-like Enzyme in Mast Cells

1960 • 159 citations

Mast cell chymase. A potent secretagogue for airway gland serous cells.

1989 • 153 citations

Angiotensin I Conversion by Human and Rat Chymotryptic Proteinases

1984 • 152 citations

Substrate specificity of the chymotrypsin-like protease in secretory granules isolated from rat mast cells.

1987 • 144 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

CHLOROACYL ESTERS AS HISTOCHEMICAL SUBSTRATES

1953 • 135 citations

Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I.

1983 • 129 citations

Identification of a chymotrypsin-like proteinase in human mast cells.

1986 • 128 citations

Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family.

1987 • 122 citations

Chymotrypsin- and trypsin-type serine proteases in rat mast cells: Properties and functions

1985 • 120 citations

Myelomonocytic cell lineage expression of the neutrophil elastase gene.

1988 • 119 citations

Inactivation of human high molecular weight kininogen by human mast cell tryptase.

1983 • 119 citations

Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans.

1987 • 118 citations

Monoclonal antibodies against human mast cell tryptase demonstrate shared antigenic sites on subunits of tryptase and selective localization of the enzyme to mast cells.

1985 • 118 citations

Intestinal mucosal mast cells from rats infected with Nippostrongylus brasiliensis contain protease-resistant chondroitin sulfate di-B proteoglycans.

1986 • 116 citations

The structure of rat mast cell protease II at 1.9-angstrom resolution

1988 • 112 citations

Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.

1983 • 102 citations

Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

1987 • 99 citations

Amino acid sequence of rat mast cell protease I (chymase)

1987 • 96 citations

Structure, specificity and localization of the serine proteases of connective tissue

1980 • 95 citations

Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret.

1989 • 94 citations

Human skin tryptase: purification, partial characterization and comparison with human lung tryptase

1988 • 91 citations

Release of tryptase together with histamine during the immediate cutaneous response to allergen

1987 • 88 citations

Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation

1989 • 84 citations

Dog mastocytoma tryptase: Affinity purification, characterization, and amino-terminal sequence

1987 • 78 citations

Amino acid sequence of a mouse mucosal mast cell protease

1989 • 77 citations

Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity

1988 • 74 citations

Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G

1980 • 73 citations

Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines.

1988 • 63 citations

Elevated Histamine and Tryptase Levels in Smokers’ Bronchoalveolar Lavage Fluid

1988 • 62 citations

Binding of heparin to human high molecular weight kininogen

1989 • 57 citations

Dog Tracheal Epithelial Cells in Culture Synthesize Sulfated Macromolecular Glycoconjugates and Release Them from the Cell Surface upon Exposure to Extracellular Proteinases

1987 • 56 citations

Inactivation of bradykinin and kallidin by cathepsin G and mast cell chymase

1985 • 54 citations

Isolated canine mastocytoma cells: propagation and characterization of two cell lines

1986 • 53 citations

Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.

1988 • 49 citations

Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.

1988 • 47 citations

Influence of Neuropeptides on Airway Smooth Muscle

1987 • 43 citations

Tryptase from rat mast cells converts bovine prothrombin to thrombin

1985 • 33 citations

The Mast Cell-specific Expression of a Protease Gene, RMCP II, Is Regulated by an Enhancer Element That Binds Specifically to Mast Cell trans-Acting Factors

1989 • 22 citations

The chloroacetate esterase reaction for mast cells in dermatopathology: a comparison with metachromatic staining methods

1982 • 19 citations

Dog mastocytoma proteoglycans: occurrence of heparin and oversulfated chondroitin sulfates, containing trisulfated disaccharides, in three cell lines

1988 • 18 citations

Characterization of Sheep Alpha-1-Proteinase Inhibitor: Important Differences from the Human Protein

1988 • 15 citations