Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

The preparation and properties of two new chromogenic substrates of trypsin

1961 • 3,319 citations

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

1979 • 602 citations

[28] Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates

1981 • 310 citations

Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.

1982 • 298 citations

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

1979 • 270 citations

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

1978 • 264 citations

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

1977 • 224 citations

Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes.

1984 • 193 citations

Human α-1-antichymotrypsin: interaction with chymotrypsin-like proteinases

1978 • 174 citations

[63] Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone

1981 • 170 citations

Covalent structure of a group-specific protease from rat small intestine. Appendix: Crystallographic data for a group specific protease from rat intestine

1978 • 144 citations

Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I.

1983 • 129 citations

Systemic release of mucosal mast-cell protease in primed rats challenged with Nippostrongylus brasiliensis.

1983 • 123 citations

Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G.

1981 • 118 citations

Substrate specificity and kinetic characteristics of angiotensin converting enzyme

1983 • 113 citations

A major serine protease in rat skeletal muscle: Evidence for its mast cell origin

1978 • 107 citations

The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G.

1982 • 107 citations

Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of .alpha.1-protease inhibitor (.alpha.1-antitrypsin)

1980 • 97 citations

Structure, specificity and localization of the serine proteases of connective tissue

1980 • 95 citations

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

1984 • 91 citations

Granulocyte-angiotensin system. Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin G

1984 • 83 citations

Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G

1980 • 73 citations

[45] Mast cell proteases

1981 • 73 citations

Uninvolved Skin from Psoriatic Patients Develops Signs of Involved Psoriatic Skin After Being Grafted onto Nude Mice

1982 • 72 citations

Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin.

1983 • 70 citations

Purification of an atypical mast cell protease and its levels in developing rats

1978 • 68 citations

Reaction of azapeptides with chymotrypsin-like enzymes. New inhibitors and active site titrants for chymotrypsin A alpha, subtilisin BPN', subtilisin Carlsberg, and human leukocyte cathepsin G.

1984 • 68 citations

Reactivity of human leukocyte elastase and porcine pancreatic elastase toward peptide-4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is selective for crosslinked regions of elastin

1981 • 62 citations

Inhibition of elastase and other serine proteases by heterocyclic acylating agents.

1980 • 56 citations

Kinetics of the reaction of chymotrypsin A_α with peptide chloromethyl ketones in relation to its subsite specificity

1973 • 55 citations

Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors.

1982 • 46 citations

Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl flourides

1978 • 45 citations

Reaction of peptide thiobenzyl esters with mammalian chymotrypsinlike enzymes: A sensitive assay method

1981 • 33 citations

Selective inhibition of human leukocyte elastase and bovine alpha-chymotrypsin by novel heterocycles.

1981 • 31 citations

Purification and partial characterization of an α-chymotrypsin-like protease of rat peritoneal mast cells

1979 • 26 citations

Catalysis by human leukocyte elastase. Rate-limiting deacylation for specific p-nitroanilides and amides

1984 • 21 citations

Mapping of the substrate-binding site of the human granulocyte elastase by the aid of tripeptidyl-p-nitroanilide substrates

1980 • 16 citations

Selective Cleavage of Peptide Bonds by a Serine Protease from the Muscle Layer of Rat Small Intestine1

1978 • 15 citations