The Nature of the Glomerulus: Pressure-Induced and Metabolic Aberrations

Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation

1981 • 1,664 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Mechanotransduction and the functional response of bone to mechanical strain

1995 • 1,008 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

Integrins as mechanochemical transducers

1991 • 684 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat

1991 • 395 citations

Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade.

1995 • 356 citations

Cellular events in the evolution of experimental diabetic nephropathy

1995 • 320 citations

Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

1995 • 307 citations

mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

1993 • 300 citations

Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells

1993 • 288 citations

Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.

1992 • 270 citations

Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.

1993 • 254 citations

Physical properties of isolated perfused renal tubules and tubular basement membranes

1972 • 203 citations

Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney.

1995 • 198 citations

Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells.

1996 • 174 citations

Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy.

1995 • 150 citations

Fast accumulation of basement membrane material and the rate of morphological changes in acute experimental diabetic glomerular hypertrophy

1980 • 149 citations

Proton conductance of the plasma membrane: properties, regulation, and functional role

1993 • 136 citations

Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity.

1992 • 136 citations

Absence of glomerular injury or nephron loss in a normotensive rat remnant kidney model

1990 • 129 citations

Structure of the glomerular mesangium: a biomechanical interpretation.

1990 • 125 citations

Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells

1993 • 120 citations

Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells

1993 • 119 citations

Continuous telemetric blood pressure monitoring and glomerular injury in the rat remnant kidney model

1993 • 116 citations

Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase

1994 • 112 citations

Effects of different antihypertensive treatments on morphologic progression of diabetic nephropathy in uninephrectomized dogs

1994 • 109 citations

Glomerular hypertrophy accelerates hypertensive glomerular injury in rats

1991 • 105 citations

Contractile Activity of Human Glomeruli in Culture

1969 • 91 citations

PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line

1994 • 88 citations

Effects of tissue preparation on glomerular volume and capillary structure in the rat.

1990 • 85 citations

Impaired autoregulation of glomerular capillary hydrostatic pressure in the rat remnant nephron.

1991 • 82 citations

Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis

1985 • 81 citations

Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells

1995 • 80 citations

Early glycosilation products induce glomerular hyperfiltration in normal rats

1992 • 77 citations

Effects of Polyol-Pathway Inhibition and Dietary myo-Inositol on Glomerular Hemodynamic Function in Experimental Diabetes Mellitus in Rats

1991 • 76 citations

Effects of reduced renal mass on tissue lipids and renal injury in hyperlipidemic rats

1989 • 76 citations

Changes in organization and composition of the extracellular matrix underlying cultured endothelial cells exposed to laminar steady shear stress.

1995 • 76 citations

Smooth muscle stretch-activated phospholipase C activity

1995 • 73 citations

Cyclic AMP inhibits increased collagen production by cyclically stretched smooth muscle cells.

1987 • 68 citations

Increased glomerular capillary pressure alters glomerular cytokine expression.

1994 • 59 citations

High glucose and TGFβ1 stimulate fibronectin gene expression through a cAMP response element

1994 • 59 citations

Glomerular volume expansion and mesangial cell mechanical strain: mediators of glomerular pressure injury.

1994 • 50 citations

Regulation of glomerular volume in normal and partially nephrectomized rats

1996 • 44 citations

Juxtamedullary microvascular dysfunction during the hyperfiltration stage of diabetes mellitus

1994 • 41 citations

Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes

1993 • 40 citations

Physics for the health sciences

1981 • 37 citations

Physics for the Health Sciences

1975 • 37 citations

Administration of AGEs in vivo induces genes implicated in diabetic glomerulosclerosis.

1995 • 30 citations

Comparison of Glomerular and Mesangial Prostaglandin Synthesis and Glomerular Contraction in Two Rat Models of Diabetes Mellitus

1987 • 29 citations

Mechanism of action of angiotensin II on isolated rat glomeruli

1989 • 28 citations

Effect of mesangiolysis on autoregulation of renal blood flow and glomerular filtration rate in rats

1992 • 25 citations

Effect of Mechanical Forces on Extracellular Matrix Synthesis by Bovine Urethral Fibroblasts in Vitro

1993 • 25 citations

The Effect of Selective Growth Hormone Defect in the Progression of Glomerulosclerosis

1994 • 24 citations

Mesangial structure and function in the remnant kidney

1991 • 19 citations

Twenty-four hour blood pressure variability: clinical implications.

1992 • 17 citations

Proteinuria, lipoproteins and renal apolipoprotein deposits in uninephrectomized female analbuminemic rats

1995 • 16 citations

High glucose induces Vascular Permeability Factor protein secretion in cultured human mesangial cells

1996 • 1 citations