Lysosomal Enzymes as Agents of Turnover of Soluble Cytoplasmic Proteins

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Functions of Lysosomes

1966 • 2,942 citations

Molecular Weight Determination of Protein-Dodecyl Sulfate Complexes by Gel Electrophoresis in a Discontinuous Buffer System

1971 • 2,019 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

Hydrolysis of Proteins

1965 • 408 citations

A new assay for cathepsin B1 and other thiol proteinases

1972 • 394 citations

Lysosomes, a Laboratory Handbook

1973 • 383 citations

Human cathepsin B1. Purification and some properties of the enzyme

1973 • 322 citations

Cathepsin D. Purification of isoenzymes from human and chicken liver

1970 • 273 citations

Digestive Activity of Lysosomes

1968 • 254 citations

RAT-KIDNEY LYSOSOMES: ISOLATION AND PROPERTIES

1965 • 251 citations

Protein Degradation in Cultured Cells

1973 • 195 citations

Lysosomal acid proteinase of rabbit liver

1967 • 182 citations

Studies on the Correlation between Size and Relative Degradation Rate of Soluble Proteins

1973 • 165 citations

The inhibition of tissue acid proteinases by pepstatin

1972 • 141 citations

Measurement of intralysosomal pH

1973 • 114 citations

Influence of the Injection of Triton Wr-1339 On the Properties of Rat-Liver Lysosomes

2008 • 114 citations

THE STRUCTURE OF PEPSTATIN

1970 • 107 citations

STRUCTURE AND ENZYMATIC BREAK-DOWN OF PROTEINS

1950 • 104 citations

Role of individual cathepsins in lysosomal protein digestion as tested by specific inhibitors

1974 • 104 citations

The relationship of intracellular pathways of iron metabolism to cellular iron overload and the iron storage diseases. Cell sap and cytocavitary network pathways in relation to lysosomal storage and turnover of iron macromolecules.

1973 • 90 citations

Ion distribution in lysosomal suspensions

1973 • 83 citations

IMMUNOINHIBITION OF INTRACELLULAR PROTEIN DIGESTION IN MACROPHAGES

1973 • 82 citations

Relationship between Degradation Rates of Proteins in Vivo and Their Susceptibility to Lysosomal Proteases

1974 • 77 citations

Some characteristics of the alanine aminotransferase- and arginase-inactivating system of lysosomes

1972 • 67 citations

Proteolysis in homogenates of perfused rat liver: Responses to insulin, glucagon and amino acids

1973 • 62 citations

Effect of ATP on Protein Degradation in Rat Liver Lysosomes

1973 • 50 citations

Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D

1972 • 44 citations

What determines the half-life of proteins in, vivo? Some experiences with alanine aminotransferase of rat tissues

1969 • 42 citations

Involvement of thiol enzymes in the lysosomal breakdown of native and denatured proteins

1973 • 38 citations

Regulation of Tyrosine Aminotransferase in Rat Liver

1973 • 29 citations

Inactivation of tyrosine aminotransferase in neutral homogenates and rat liver slices

1972 • 27 citations

The synthesis and degradation of membrane proteins.

1973 • 19 citations

Proteolysis at neutral pH in a lysosomal‐cytosol system can not be attributed to the uptake of proteins into lysosomes

1974 • 16 citations

Facilitation of lysosome disruption by ATP at low pH

1974 • 15 citations

Turnover of Lysosomal Proteins and Induction and Distribution of Rat Liver Proteinases, after Treatment with Triton WR-1339

1975 • 13 citations

Intracellular protein breakdown. II. Breakdown of proteins from rat liver cytosol by endopeptidase.

1971 • 7 citations

A study of a tyrosine aminotransferase inactivating system in rat liver homogenate

1971 • 6 citations