An Overview on Possible Mechanisms of Destruction of the Insulin-Producing Beta Cell

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Virus-Induced Diabetes Mellitus

1979 • 1,011 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY

1983 • 710 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

DO CD4-POSITIVE CYTOTOXIC T CELLS DAMAGE ISLET β CELLS IN TYPE 1 DIABETES?

1988 • 470 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

1990 • 454 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

1984 • 432 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Interferon-gamma induces HLA-DR expression by thyroid epithelium.

1985 • 314 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Inhibitory Effects of Interleukin 1 on Insulin Secretion, Insulin Biosynthesis, and Oxidative Metabolism of Isolated Rat Pancreatic Islets*

1987 • 278 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE-I DIABETES: POSSIBLE MONITORS OF ACTIVE BETA-CELL DAMAGE

1980 • 265 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

1979 • 212 citations

Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice

1988 • 199 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

Pancreatic islet-cell damage in children with fatal viral infections.

1980 • 185 citations

CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS

1983 • 183 citations

Competitive Insulin Autoantibody Assay: Prospective Evaluation of Subjects at High Risk for Development of Type I Diabetes Mellitus

1987 • 181 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes.

1988 • 168 citations

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.

1986 • 156 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Preventive effects of Cyclosporin on diabetes in NOD mice

1986 • 155 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Autoantibodies to a 64-Kilodalton Islet Cell Protein Precede the Onset of Spontaneous Diabetes in the BB Rat

1984 • 147 citations

The spontaneously diabetic Wistar rat. Metabolic and morphologic studies

1977 • 145 citations

T-cell receptor-specific monoclonal antibodies against a V ? 11-positive mouse T-cell clone

1988 • 139 citations

Transgenic Mice with I-A on Islet Cells Are Normoglycemic But Immunologically Intolerant

1989 • 135 citations

Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus

1989 • 122 citations

Thein VitroRegulation of Human Thyrocyte HLA-DR Antigen Expression*

1985 • 121 citations

Distinct Macrophage Subpopulations in Pancreas of Prediabetic BB/E Rats: Possible Role for Macrophages in Pathogenesis of IDDM

1988 • 116 citations

Virus-Induced Diabetes Mellitus: Reovirus Infection of Pancreatic β Cells in Mice

1978 • 115 citations

Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

1985 • 111 citations

Combined Treatment With Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice

1986 • 110 citations

Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans

1986 • 109 citations

Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice

1987 • 96 citations

An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.

1988 • 91 citations

Suppressor T cells in experimental autoimmune haemolytic anaemia

1978 • 89 citations

Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes

1983 • 88 citations

Development of autoimmune insulitis is prevented in Eα^d but not in Aβ^k NOD transgenic mice

1989 • 88 citations

NOD Marrow Stem Cells Adoptively Transfer Diabetes to Resistant (NOD × NON)F1 Mice

1988 • 87 citations

Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD X B10) F1 mice with bone marrow cells from NOD mice.

1988 • 82 citations

Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus.

1981 • 81 citations

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1988 • 79 citations

Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.

1986 • 77 citations

Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

1984 • 76 citations

The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males

1990 • 76 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

1988 • 72 citations

Administration of silica prevents diabetes in BB-rats

1985 • 70 citations

Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat

1984 • 69 citations

Spontaneous Diabetes Mellitus in the BB/W Rat: Effects of Glucocorticoids, Cyclosporin-A, and Antiserum to Rat Lymphocytes

1983 • 68 citations

T-lymphocyte clone specific for pancreatic islet antigen

1988 • 67 citations

Suppression of Overt Diabetes in NOD Mice by Anti-thymocyte Serum or Anti-Thy 1, 2 Antibody

1986 • 66 citations

Antigen processing and CD4+ T cell depletion in AIDS

1988 • 65 citations

Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues.

1989 • 65 citations

Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus

1987 • 64 citations

Antigen expression of the pancreatic beta‐cells is dependent on their functional state, as shown by a specific, BB rat monoclonal autoantibody IC2

1988 • 63 citations

Progression From Insulitis to β-Cell Destruction in NOD Mouse Requires L3T4+ T-Lymphocytes

1988 • 63 citations

Association of β-Cell–Specific Expression of Endogenous Retrovirus With Development of Insulitis and Diabetes in NOD Mouse

1988 • 60 citations

Interferon-γ Induces the Expression of HLA-A,B,C but Not HLA-DR on Human Pancreatic β-Cells*

1986 • 56 citations

Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes mellitus

1989 • 52 citations

Natural killer cell number and function in the spontaneously diabetic BB/W rat.

1986 • 50 citations

Glucose induces intracisternal type A retroviral gene transcription and translation in pancreatic beta cells.

1986 • 48 citations

The involvement of Ly 2+ T cells in beta cell destruction

1990 • 47 citations

AUTOIMMUNITY AND IDIOTYPES

1984 • 47 citations

In situ analysis of pancreatic islets in rats developing diabetes. Appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity.

1988 • 45 citations

Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice

1986 • 44 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

Phenotypic characteristics of cells involved in induced suppression to murine experimental autoimmune thyroiditis

1988 • 40 citations

IDDM in BB Rats: Enhanced MHC Class I Heavy-Chain Gene Expression in Pancreatic Islets

1988 • 37 citations

Interferon-Mediated Induction of la Antigen Expression on Isolated Murine Whole Islets and Dispersed Islet Cells

1986 • 37 citations

NODマウスにおける抗胸腺細胞血清ならびに抗体Thy 1, 2抗体投与による顕性糖尿発症の抑制

1986 • 34 citations

Induction of class II MHC antigens in vitro on pancreatic B cells isolated from BB/E rats

1986 • 33 citations

Progression from insulitis to beta-cell destruction in NOD mouse requires L3T4+ T-lymphocytes

1988 • 29 citations

THE EFFECT OF H-2 COMPATIBILITY ON PANCREATIC BETA CELL SURVIVAL IN THE NONOBESE DIABETIC MOUSE

1988 • 27 citations

Association of beta-cell-specific expression of endogenous retrovirus with development of insulitis and diabetes in NOD mouse

1988 • 24 citations

Interleukin 2 Activates BB/W Diabetic Rat Lymphoid Cells Cytotoxic to Islet Cells

1987 • 19 citations

Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells

1985 • 18 citations

Insulin autoantibodies, islet cell surface antibodies and the development of spontaneous diabetes in the BB/Edinburgh rat.

1987 • 17 citations

Cyclosporin prophylaxis induces long-term prevention of diabetes, and inhibits lymphocytic infiltration in multiple target tissues in the high-risk BB rat.

1986 • 17 citations

Interferon-mediated induction of Ia antigen expression on isolated murine whole islets and dispersed islet cells

1986 • 15 citations

Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell

1988 • 15 citations

Interferon-γ Induces Class II MHC Antigens on RINm5F Cells

1988 • 13 citations

Interleukin 2 activates BB/W diabetic rat lymphoid cells cytotoxic to islet cells

1987 • 10 citations

Interferon-gamma induces class II MHC antigens on RINm5F cells

1988 • 4 citations