Determination of free extracellular levels of methotrexate by microdialysis in muscle and solid tumor of the rabbit.

Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study.

1991 • 227 citations

The clinical pharmacology of methotrexate

1983 • 213 citations

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.

1982 • 87 citations

In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-Bearing rats

1996 • 52 citations

Microdialysis sampling in tumor and muscle: Study of the disposition of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (SR 4233)

1994 • 51 citations

Muscle Microdialysis as a Model Study to Relate the Drug Concentration in Tissue Interstitial Fluid and Dialysate.

1991 • 50 citations

Determination of Free Extracellular Concentrations of Piperacillin by Microdialysis

1996 • 45 citations

The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain.

1995 • 42 citations

Formation and disposition of 7-hydroxymethorexate in rabbits

1983 • 35 citations

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits after intravenous administration

1983 • 31 citations

Tissue metabolism and distribution of methotrexate in rabbits.

1982 • 27 citations

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits

1985 • 23 citations

Comparison of high-performance liquid chromatography and the Abbott Fluorescent Polarization Radioimmunoassay in the measurement of methotrexate

1989 • 22 citations

Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography.

1990 • 21 citations

Determination of extracellular methotrexate tissue levels by microdialysis in a rat model

1996 • 21 citations

Evaluation of methotrexate tissue exposure by in situ microdialysis in a rat model

1994 • 20 citations

Pharmacokinetics of different doses of methotrexate at steady state by in situ microdialysis in a rat model

1995 • 19 citations

Biochemical and pharmacological consequences of the interaction between methotrexate and ketoprofen in the rabbit

1990 • 14 citations

Protein binding of indomethacin, methotrexate and morphine in patients with cancer.

1992 • 12 citations

[Trial of experimental induction of cerebral metastasis in the rabbit carrying a VX2 tumor].

1975 • 3 citations