The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain.

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine

1989 • 281 citations

Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays

1970 • 260 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.

1982 • 184 citations

Permeability of Different Experimental Brain Tumor Models to Horseradish Peroxidase

1982 • 167 citations

Application of Quantitative Autoradiographic Measurements in Experimental Brain Tumor Models

1981 • 138 citations

Optimizing drug delivery to brain tumors

1987 • 118 citations

Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain

1994 • 106 citations

Changes of the blood-brain barrier in experimental metastatic brain tumors

1983 • 103 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Growth of human lung tumor in the brain of the nude rat as a model to evaluate antitumor agent delivery across the blood-brain barrier.

1985 • 73 citations

Principles of brain tumor chemotherapy.

1986 • 72 citations

Molecular mechanism of multidrug resistance in tumor cells.

1987 • 66 citations

Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

1995 • 65 citations

Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a quantitative autoradiographic study.

1988 • 56 citations

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

1988 • 49 citations

The use of microdialysis in pharmacokinetics and pharmacodynamics

1991 • 39 citations

The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics.

1995 • 34 citations

Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues

1984 • 29 citations

Animal Models: Blood-Brain Barrier and Pharmacology

2015 • 6 citations