Immunotherapy with Antibodies to Core Lipopolysaccharide: A Critical Appraisal

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

PREVENTION OF GRAM-NEGATIVE SHOCK AND DEATH IN SURGICAL PATIENTS BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID

1985 • 381 citations

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

1985 • 316 citations

Preparation and Properties of Antisera against the Lipid‐A component of Bacterial Lipopolysaccharides

1971 • 316 citations

FRACTURES OF THE NECK OF THE FEMUR

1952 • 283 citations

Treatment of Gram-Negative Septic Shock with Human IgG Antibody to Escherichia coli J5: A Prospective, Double-Blind, Randomized Trial

1988 • 266 citations

Treatment of E. Coli and Klebsiella Bacteremia in Agranulocytic Animals with Antiserum to a UDP-GAL Epimerase-Deficient Mutant

1973 • 216 citations

Immunization with R mutants of S. Minnesota. I. Protection against challenge with heterologous gram-negative bacilli.

1972 • 197 citations

A Proposed Mechanism for Natural Immunity to Enterobacterial Pathogens

1968 • 188 citations

Functional role of antibody against "core" glycolipid of Enterobacteriaceae.

1975 • 156 citations

Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies.

1990 • 150 citations

Passive Immunization against the Local Shwartzman Reaction

1972 • 142 citations

Direct measurement of antibody affinity distribution by Haften-inhibition enzyme immunoassay

1984 • 129 citations

Monoclonal antibodies specific for Escherichia coli J5 lipopolysaccharide: cross-reaction with other gram-negative bacterial species

1984 • 126 citations

Effects of IgM and IgG Antibody in Patients with Bacteremia Due to Gram-Negative Bacilli

1976 • 123 citations

Immunization with Rough Mutants of Salmonella minnesota. IV. Protection by Antisera to O and Rough Antigens Against Endotoxin

1983 • 112 citations

Immunization with Rough Mutants of Salmonella minnesota: Protective Activity of IgM and IgG Antibody to the R595 (Re Chemotype) Mutant

1988 • 104 citations

Prevention of lethal pseudomonas bacteremia with epimerase-deficient E. coli antiserum.

1975 • 90 citations

Immunization with R Mutants of S. Minnesota

1972 • 90 citations

Bacterial Endotoxin:Molecular Relationships Between Structure and Activity

1991 • 86 citations

Protective Antibody to Endotoxin Core: The Emperor's New Clothes?

1988 • 85 citations

Immunization with R mutants of Salmonella minnesota. II. Comparison of the protective effect of immunization with lipid A and the Re mutant

1977 • 84 citations

Relationship of Structure to Function in Bacterial Endotoxins: Serologically Cross-reactive Components and their Effect on Protection of Mice against some Gram-negative Infections

1976 • 80 citations

Cross-Reactivity of Rabbit Antibodies to Lipopolysaccharides of Escherichia coli J5 and Other Gram-Negative Bacteria

1985 • 80 citations

Human monoclonal antibodies that recognize conserved epitopes in the core-lipid A region of lipopolysaccharides.

1987 • 79 citations

Monoclonal Antibodies for treatment of Gram-Negative Infections

1989 • 78 citations

Neutralization of meningococcal endotoxin by antibody to core glycolipid.

1978 • 77 citations

Immunization with R mutants of Salmonella minnesota. II. Serological response to lipid A and the lipopolysaccharide of Re mutants

1977 • 77 citations

Specificity and Cross-Reactivity of Monoclonal Antibodies Reactive with the Core and Lipid A Regions of Bacterial Lipopolysaccharide

1989 • 75 citations

Experimental gram-negative bacterial sepsis: prevention of mortality not preventable by antibiotics alone

1979 • 71 citations

Experimental Gram-Negative Bacterial Sepsis: Reevaluation of the Ability of Rough Mutant Antisera to Protect Mice

1978 • 70 citations

Mouse monoclonal antibodies reactive with J5 lipopolysaccharide exhibit extensive serological cross-reactivity with a variety of gram-negative bacteria

1984 • 68 citations

Failure of Monoclonal Antibodies to Core Glycolipid to Bind Intact Smooth Strains of Escherichia coli

1985 • 67 citations

Isolation and characterization of murine monoclonal antibodies specific for gram-negative bacterial lipopolysaccharide: association of cross-genus reactivity with lipid A specificity

1987 • 66 citations

Protection Against Gram-Negative Infections with Antiserum to Lipid A from Salmonella minnesota R595

1974 • 66 citations

Characterization of murine monoclonal antibodies to Escherichia coli J5

1986 • 64 citations

ELISA-Methode zur Bestimmung von Anti-Lipoid-A-Antikörpern, Lipopolysacchariden und anderen hydrophoben Antigenen

1989 • 63 citations

Failure of Antisera to J5 and R595 Rough Mutants to Reduce Endotoxemic Lethality

1988 • 60 citations

Efficacy of type-specific and cross-reactive murine monoclonal antibodies directed against endotoxin during experimental sepsis.

1985 • 53 citations

Antibodies to Core Lipopolysaccharide Determinants: Absence of Cross-reactivity with Heterologous Lipopolysaccharides

1991 • 52 citations

Ineffectiveness of single-dose human antiserum to core glycolipid (E. coli J5) for prophylaxis of bacteremic, gram-negative infections in patients with prolonged neutropenia.

1983 • 52 citations

Type-Specific vs. Cross-Protective Vaccination for Gram-Negative Bacterial Pneumonia

1981 • 51 citations

Therapeutic Monoclonal Antibodies

1990 • 50 citations

Antibodies to Lipopolysaccharides after Immunization of Humans with the Rough Mutant Escherichia coli J5

1991 • 49 citations

Cross-Reactive Immunoprotective Antibodies to Escherichia coli 0111 Rough Mutant J5

1985 • 46 citations

Lipid A and Anti-Lipid A

1979 • 46 citations

Cross-Reactivity of Monoclonal Antibodies to Escherichia coli J5 with Heterologous Gram-Negative Bacteria and Extracted Lipopolysaccharides

1989 • 41 citations

Mechanisms of Bacterial Opsonization by Immune Globulin Intravenous: Correlation of Complement Consumption with Opsonic Activity and Protective Efficacy

1989 • 39 citations

Implications of Endotoxin Contamination in the Evaluation of Antibodies to Lipopolysaccharides in a Murine Model of Gram-Negative Sepsis

1987 • 38 citations

Production and characterisation of mouse monoclonal antibodies reacting with the lipopolysaccharide core region of gram-negative bacilli

1988 • 36 citations

Antiserum gegen Escherichia coli J5: Erneute Beurteilung seiner In vitro- und In-vivo-Aktivität gegen heterologe gramnegative Bakterien

1985 • 35 citations

Analysis of the fine specificity and cross-reactivity of monoclonal anti-lipid A antibodies.

1986 • 35 citations

Experimental Gram-Negative Bacterial Sepsis: Optimal Methylprednisolone Requirements for Prevention of Mortality Not Preventable by Antibiotics Alone

1982 • 34 citations

Demonstration of Cross-Reactive Antibodies to Smooth Gram-Negative Bacteria in Antiserum to Escherichia coli J5

1987 • 33 citations

Synthetic Salmonella-type lipid A antigen with high serological specificity

1986 • 33 citations

Antibody specific for Escherichia coli J5 cross-reacts to various degrees with an Escherichia coli clinical isolate grown for different lengths of time

1987 • 32 citations

"Core" Glycolipid of Enterobacteriaceae: Immunofluorescent Detection of Antigen and Antibody

1975 • 29 citations

Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection

1987 • 29 citations

Limited protective effect of rough mutant antisera in murine Escherichia coli bacteremia

1982 • 28 citations

Effect of active and passive immunizations with lipid A and salmonella minnesota Re 595 on gram-negative infections in mice

1976 • 25 citations

Randomized Placebo-controlled Study of E5 Monoclonal Antiendotoxin Antibody

1990 • 25 citations

Cross-Protective Immunity to Gram-Negative Bacilli: Studies with Core Glycolipid of Salmonella minnesota and Antigens of Streptococcus pneumoniae

1977 • 24 citations

Binding characteristics and cross-reactivity of three different antilipid A monoclonal antibodies.

1989 • 19 citations

Reactivity of Antibodies to Core Glycolipid with Gram-Negative Bacteria

1987 • 17 citations

Immunochemical Specificity of Human Antibodies to Lipopolysaccharide from the J5 Rough Mutant of Escherichia coli O111:B4

1989 • 13 citations

Detection by Immunofluorescence of Common Antigenic Determinants in Unrelated Gram-Negative Bacteria and Their Lipopolysaccharides

1977 • 12 citations

Immunotherapy of Gram-negative Septic Shock

1990 • 5 citations